ID   NM111_PICST             Reviewed;         983 AA.
AC   A3LX99;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Pro-apoptotic serine protease NMA111;
DE            EC=3.4.21.-;
GN   Name=NMA111; Synonyms=PDZ1; ORFNames=PICST_47702;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; CP000500; ABN67426.1; -; Genomic_DNA.
DR   RefSeq; XP_001385455.1; XM_001385418.1.
DR   AlphaFoldDB; A3LX99; -.
DR   SMR; A3LX99; -.
DR   STRING; 4924.XP_001385455.1; -.
DR   EnsemblFungi; ABN67426; ABN67426; PICST_47702.
DR   GeneID; 4839935; -.
DR   KEGG; pic:PICST_47702; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   InParanoid; A3LX99; -.
DR   OMA; CVFDNHE; -.
DR   OrthoDB; 93889at2759; -.
DR   Proteomes; UP000002258; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..983
FT                   /note="Pro-apoptotic serine protease NMA111"
FT                   /id="PRO_0000320360"
FT   DOMAIN          287..365
FT                   /note="PDZ 1"
FT   DOMAIN          867..948
FT                   /note="PDZ 2"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..260
FT                   /note="Serine protease"
FT   COMPBIAS        1..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        108
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        139
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        222
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   983 AA;  110475 MW;  7D5FB9CF4F97595A CRC64;
     MSVPTKRRLS FDESTNKRFL NGTHSTENNT SNIEVDEDYG SDGSEQIFDL PATTNNNQWQ
     ETITKVVNAV VSIQFTHVSN FDTETSLVSE ATGFVVDATR GLILTNRHVV GPGPFCGYVV
     FDNHEEAVVK PIYRDPVHDF GFLQFDPKEV KYLQLTQLEL KPDLAKVGTE IRVVGNDAGE
     KLSILAGFIS RLDRNAPEYG SLTYNDFNTE YIQAAASASG GSSGSPVVNE DGDVVALQAG
     GSTEASTDFF LPIYRPLRAL QCIQKKQPIT RGDIQVEWQL KPYDECRRLG LTPEAEARAR
     KLFPNKIGLL VAELVLPQGQ ADGLIKEGDT LISIDDIDIS TFIKVDEILD ENVGNELKFV
     IQRGGEVITQ MIKIGDLHSI TPDRYVDVGG ASFNNLSYQV ARCYCIPVKG VFINDASGSF
     EFASYEKSGW LLETVDDMPT PDLDTLIEVM KMIPDCRRVP ITYRHVSDLH TENIQIIYIE
     RHWQSSFRLA VRNDTTGLWD FTDLQEKPLP PLSHEPQNAK FIDIPFSDET RSGCSSLVRS
     FVQVRLIAPV PMDSYPYRKE ICYGVVVDSV NGYVLVSRRF VPHDMCDIFL IFAESIDVPA
     KVVFLHPNQN YAILKYDPSL VLADVKTPKF GDKPLKRGEK SYFIGYNYNL RLVTDDVKIS
     GVSSLNIPPA SLSPRYRGTN LECILLDSKI SVECDSGVLA DDDGTVRAFW ITYLGEATCD
     QGSDRMYRMG LDVTDVLSVI EKLKVNEIPK QLRLLEAEFT SVTILQGRTR GVSQEWINKF
     EEVCEDEIKF LAVERVSAPT LHQEKNPLKA GDIILSVNDI IVKNMRDLKP MFTEQELKFR
     IIRQKKETEI VVPTIDTTTI NTSHVVFWSG AIIQAPHYAV RQLMERVPSE VYVTRKSAGG
     PAHQYGIATN SFITHVNDVE TKDLVSLMKV VKDIPDNTYI KLRLMSFDNV PIAISLKTNY
     HYFPTSELKK KEGSDEWIEI EHK