ID   NM111_YARLI             Reviewed;         984 AA.
AC   Q6BZQ9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Pro-apoptotic serine protease NMA111;
DE            EC=3.4.21.-;
GN   Name=NMA111; OrderedLocusNames=YALI0F31603g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG78916.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CR382132; CAG78916.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_506103.1; XM_506103.1.
DR   AlphaFoldDB; Q6BZQ9; -.
DR   SMR; Q6BZQ9; -.
DR   STRING; 4952.CAG78916; -.
DR   GeneID; 2907906; -.
DR   KEGG; yli:YALI0F31603g; -.
DR   InParanoid; Q6BZQ9; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF13180; PDZ_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..984
FT                   /note="Pro-apoptotic serine protease NMA111"
FT                   /id="PRO_0000320362"
FT   DOMAIN          268..346
FT                   /note="PDZ 1"
FT   DOMAIN          756..826
FT                   /note="PDZ 2"
FT   REGION          51..241
FT                   /note="Serine protease"
FT   ACT_SITE        89
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        120
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        203
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   984 AA;  108596 MW;  EE711A454020045A CRC64;
     MVPQKRSRDD LNGLKSPVRS PKKIAMPAAT SASNGVVAGW HSTIEKVVKS VVSIQFAQVA
     SFDCESAVVS EATGFVVDTE MGIIMTNRHV VGAGPFCGYA VFDNHEECEL VPIYRDPVHD
     FGFLKFDPSK IKYMNVQKLR LCPEKAQVGT EIRVVGNDNG EKLSILSGFI SRLDRNAPDY
     GDLTYNDFNT EYIQAAASAS GGSSGSPVVD IDGDAIALQA GGSTDASTDF FLPLNRGKRA
     LECILRGDKV TRGTIQTHWM LKPFDECRRL GLSASNEKKQ RELFPSTIGM LVAETVLPEG
     PSAVAATEGD ILLSVNSTPI SSFITLDSIL DEAVGDIVKV TVERNGAEIT FDIYVQDLHS
     ITPDRYVEVC GASFQDLSYQ LARIYAIPVR GVYVSEVGGS FRLDGQGNES KGWVVDSIDD
     IDTPDLDTFI KVIAAIPDGR RVSIRYRHLR DLHTTNFTIT YIDRKWHSSF RLAVRNDTTG
     KWDFTDLSKQ YPVPKKDEIV PQRATFTDPN LEEADAACAP LSRSFVRVSC MIPYKIDGFP
     RTMRQSHGLV VDAEKGLVLV SRSIIPYDLC NVSVTFAESV VVPGTVVFMH PLQNYAILQY
     DPKLVHADIE TAKLSSTPLK QGDPVLFMGH NLSLRLVTTR TKVSDVTAIT IPPNAGEPYY
     RALNLDAITV DSTIPNGCTA GVLADPKTGV VRAFWLSCMG ERTEGRQHEY RLGIDTSTFL
     ETVQRIRAGK PPQERFLDVE IASVSMIQAR IRGVSPEWIA AVEQDNSQRH QLFEVIRTAT
     PINGNSQALK EGDILLSING KLLTTLTTLS EAGDKEQVTI KLVRNKKEEE IQAPTTDSAF
     ETSQAVFWCG AVLQTPHHAV RQQIKKIHSG VYVSSRAQGS PAYQYLIAPT NFITHVNGTA
     TPDLETFLSV VTKIPDNTYV KLRIVTFDNV AFACSMKMNY HYFPTAEIKK EGNEWVGYSY
     KDGKRVKESD ENVEEQVNEA EKQE