ID   NMB_BOVIN               Reviewed;         121 AA.
AC   Q2T9U8;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Neuromedin-B;
DE   Contains:
DE     RecName: Full=Neuromedin-B-32;
DE   Contains:
DE     RecName: Full=Neuromedin-B;
DE   Flags: Precursor;
GN   Name=NMB;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates smooth muscle contraction (By similarity). Induces
CC       sighing by acting directly on the pre-Botzinger complex, a cluster of
CC       several thousand neurons in the ventrolateral medulla responsible for
CC       inspiration during respiratory activity (By similarity). Contributes to
CC       the induction of sneezing following exposure to chemical irritants or
CC       allergens which causes release of NMB by nasal sensory neurons and
CC       activation of NMBR-expressing neurons in the sneeze-evoking region of
CC       the brainstem (By similarity). These in turn activate neurons of the
CC       caudal ventral respiratory group, giving rise to the sneezing response
CC       (By similarity). Contributes to induction of acute itch, possibly
CC       through activation of the NMBR receptor on dorsal root ganglion neurons
CC       (By similarity). Increases expression of NMBR and steroidogenic
CC       mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion
CC       of testosterone by Leydig cells and also promotes Leydig cell
CC       proliferation (By similarity). Plays a role in the innate immune
CC       response to influenza A virus infection by enhancing interferon alpha
CC       expression and reducing expression of IL6 (By similarity). Plays a role
CC       in CSF1-induced proliferation of osteoclast precursors by contributing
CC       to the positive regulation of the expression of the CSF1 receptor CSF1R
CC       (By similarity). {ECO:0000250|UniProtKB:P01297,
CC       ECO:0000250|UniProtKB:Q9CR53}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9CR53}. Cell
CC       projection, neuron projection {ECO:0000250|UniProtKB:Q9CR53}. Note=In
CC       neurons of the retrotrapezoid nucleus//parafacial respiratory group,
CC       expressed on neuron projections which project into the pre-Botzinger
CC       complex. {ECO:0000250|UniProtKB:Q9CR53}.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   EMBL; BC111259; AAI11260.1; -; mRNA.
DR   RefSeq; NP_001068738.1; NM_001075270.2.
DR   AlphaFoldDB; Q2T9U8; -.
DR   STRING; 9913.ENSBTAP00000001825; -.
DR   PaxDb; Q2T9U8; -.
DR   GeneID; 506584; -.
DR   KEGG; bta:506584; -.
DR   CTD; 4828; -.
DR   eggNOG; ENOG502S66V; Eukaryota.
DR   InParanoid; Q2T9U8; -.
DR   OrthoDB; 1517178at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR   GO; GO:0031710; F:neuromedin B receptor binding; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0140374; P:antiviral innate immune response; ISS:UniProtKB.
DR   GO; GO:0160024; P:Leydig cell proliferation; ISS:UniProtKB.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   GO; GO:0046887; P:positive regulation of hormone secretion; IBA:GO_Central.
DR   GO; GO:0032727; P:positive regulation of interferon-alpha production; ISS:UniProtKB.
DR   GO; GO:0090290; P:positive regulation of osteoclast proliferation; ISS:UniProtKB.
DR   GO; GO:1903942; P:positive regulation of respiratory gaseous exchange; ISS:UniProtKB.
DR   GO; GO:2000845; P:positive regulation of testosterone secretion; ISS:UniProtKB.
DR   GO; GO:0160025; P:sensory perception of itch; ISS:UniProtKB.
DR   GO; GO:0160023; P:sneeze reflex; ISS:UniProtKB.
DR   InterPro; IPR000874; Bombesin.
DR   PANTHER; PTHR16866; PTHR16866; 1.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cell projection; Cleavage on pair of basic residues; Immunity;
KW   Innate immunity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250|UniProtKB:P01297"
FT   PEPTIDE         25..56
FT                   /note="Neuromedin-B-32"
FT                   /evidence="ECO:0000250|UniProtKB:P01297"
FT                   /id="PRO_0000236255"
FT   PEPTIDE         47..56
FT                   /note="Neuromedin-B"
FT                   /evidence="ECO:0000250|UniProtKB:P01297"
FT                   /id="PRO_0000236256"
FT   PROPEP          60..121
FT                   /evidence="ECO:0000250|UniProtKB:P01297"
FT                   /id="PRO_0000236257"
FT   REGION          61..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         56
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01297"
SQ   SEQUENCE   121 AA;  13157 MW;  53A3282C81980238 CRC64;
     MTLRAVGVRL LGGLLLFALL AAGAAPLGWD LPESRSRASK IRVHPRGNLW ATGHFMGKKS
     LEPPSPSLLG TAPHTSLRDQ TPQLSHHLLR VLLQKQALGM SLSVPAPNTQ HRRLLVQTLQ
     K