ID   NMB_XENLA               Reviewed;         120 AA.
AC   P43443;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Neuromedin-B;
DE   Flags: Precursor;
GN   Name=nmb;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=1409705; DOI=10.1073/pnas.89.20.9819;
RA   Wechselberger C., Kreil G., Richter K.;
RT   "Isolation and sequence of a cDNA encoding the precursor of a bombesin-like
RT   peptide from brain and early embryos of Xenopus laevis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:9819-9822(1992).
CC   -!- FUNCTION: Stimulates smooth muscle contraction.
CC       {ECO:0000250|UniProtKB:P01297}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9CR53}.
CC   -!- TISSUE SPECIFICITY: Brain, intestine, and ovaries and early embryos
CC       (stages 2 and 10). {ECO:0000269|PubMed:1409705}.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   EMBL; L01530; AAA49912.1; -; mRNA.
DR   PIR; A47201; A47201.
DR   RefSeq; NP_001079342.1; NM_001085873.2.
DR   AlphaFoldDB; P43443; -.
DR   SMR; P43443; -.
DR   GeneID; 378672; -.
DR   KEGG; xla:378672; -.
DR   CTD; 378672; -.
DR   Xenbase; XB-GENE-5967572; nmb.S.
DR   OrthoDB; 1517178at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 378672; Expressed in brain and 11 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..44
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000003024"
FT   PEPTIDE         45..54
FT                   /note="Neuromedin-B"
FT                   /evidence="ECO:0000250|UniProtKB:P01297"
FT                   /id="PRO_0000003025"
FT   PROPEP          58..120
FT                   /evidence="ECO:0000250|UniProtKB:P01297"
FT                   /id="PRO_0000003026"
FT   MOD_RES         54
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01297"
SQ   SEQUENCE   120 AA;  14384 MW;  2CB146BA082A2442 CRC64;
     MSAVPLTRML PLRFLTHLLL LSFIPLYFCM EFSEDARNIE KIRRGNQWAI GHFMGKKSLQ
     DTYNPSEQDM DSEDFRPRII EMIRGTFRQE PIRALSPRKQ DEIQWMLKKI MDDYIKTTQK