ID   NMCR_ENTCL              Reviewed;         295 AA.
AC   P52676;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Carbapenem-hydrolyzing beta-lactamase transcriptional activator;
GN   Name=nmcR;
OS   Enterobacter cloacae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX   NCBI_TaxID=550;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NOR-1;
RX   PubMed=8052644; DOI=10.1073/pnas.91.16.7693;
RA   Naas T., Nordmann P.;
RT   "Analysis of a carbapenem-hydrolyzing class A beta-lactamase from
RT   Enterobacter cloacae and of its LysR-type regulatory protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:7693-7697(1994).
CC   -!- FUNCTION: This protein is a positive regulator of gene expression of
CC       carbapenem-hydrolyzing beta-lactamase (NmcA).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; Z21956; CAA79966.1; -; Genomic_DNA.
DR   PIR; S35914; S35914.
DR   AlphaFoldDB; P52676; -.
DR   SMR; P52676; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..295
FT                   /note="Carbapenem-hydrolyzing beta-lactamase
FT                   transcriptional activator"
FT                   /id="PRO_0000105692"
FT   DOMAIN          5..62
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   295 AA;  33444 MW;  EE3D263AE2EBFC7A CRC64;
     MRARLPLNAL RAFEASARYL NFTKAGLELH VSQAAVSQQV RTLEQMLGVA LFTRVPRGLQ
     LTDEGMHLLP SITEALQMMS SAMDKFHEGK IKEVLTIAVV GTFAIGWLLP RITAFLNENP
     WIDIRILTHN NVVNLAAEGI DASIRFGTGG WINTENILLF QAPHTVLCSP ETSKKLYIPS
     DLKKVCLLRS YRKEEWNNWF KAAGIDPWTI TGPIFDSTRL MIDAVKLGDY AALVPYHMFQ
     KELNERSVAK PFEIYATLGG YWLTLQKSRV NHNSEALNVF KEWIIEHSRE FVLKS