ID   NMD3_BOVIN              Reviewed;         503 AA.
AC   Q08DS5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=60S ribosomal export protein NMD3;
GN   Name=NMD3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal medulla;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the
CC       60S ribosomal subunit. {ECO:0000250|UniProtKB:Q96D46}.
CC   -!- SUBUNIT: Found in a 60S ribosomal subunit export complex with RAN and
CC       XPO1. Interacts with XPO1. Associates with pre-60S ribosomal particles.
CC       {ECO:0000250|UniProtKB:Q96D46}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96D46}. Nucleus
CC       {ECO:0000250|UniProtKB:Q96D46}. Note=Shuttles between the
CC       nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner.
CC       {ECO:0000250|UniProtKB:Q96D46}.
CC   -!- SIMILARITY: Belongs to the NMD3 family. {ECO:0000305}.
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DR   EMBL; BC123588; AAI23589.1; -; mRNA.
DR   RefSeq; NP_001068888.1; NM_001075420.2.
DR   RefSeq; XP_010799706.1; XM_010801404.2.
DR   AlphaFoldDB; Q08DS5; -.
DR   SMR; Q08DS5; -.
DR   STRING; 9913.ENSBTAP00000021594; -.
DR   PaxDb; Q08DS5; -.
DR   PRIDE; Q08DS5; -.
DR   Ensembl; ENSBTAT00000021594; ENSBTAP00000021594; ENSBTAG00000016228.
DR   GeneID; 509871; -.
DR   KEGG; bta:509871; -.
DR   CTD; 51068; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016228; -.
DR   VGNC; VGNC:32125; NMD3.
DR   eggNOG; KOG2613; Eukaryota.
DR   GeneTree; ENSGT00390000005104; -.
DR   HOGENOM; CLU_027444_2_0_1; -.
DR   InParanoid; Q08DS5; -.
DR   OMA; ILVKKHY; -.
DR   OrthoDB; 734666at2759; -.
DR   TreeFam; TF105744; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000016228; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR   GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
DR   GO; GO:1904751; P:positive regulation of protein localization to nucleolus; IEA:Ensembl.
DR   GO; GO:1902680; P:positive regulation of RNA biosynthetic process; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR   InterPro; IPR039768; Nmd3.
DR   InterPro; IPR007064; Nmd3_N.
DR   PANTHER; PTHR12746; PTHR12746; 1.
DR   Pfam; PF04981; NMD3; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..503
FT                   /note="60S ribosomal export protein NMD3"
FT                   /id="PRO_0000323560"
FT   REGION          425..503
FT                   /note="Necessary for the nuclear export of the 60S
FT                   ribosomal subunit"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOTIF           405..422
FT                   /note="Nuclear and nucleolar localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOTIF           480..489
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOD_RES         258
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOD_RES         433
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOD_RES         468
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOD_RES         470
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
SQ   SEQUENCE   503 AA;  57748 MW;  8CA4FCC613180196 CRC64;
     MEYMTDPVKH TPGHILCCDC GVPISPNPAN ICVACLRSKV DISQGIPKQV SISFCKQCQR
     YFQPPGTWVQ CALESRDLLA LCLKKIKAPL SKVRLVDASF VWTEPHSKRL KVKLTIQKEV
     MNGAILQQVF VVDYVVQPQM CGDCHRVEAK DFWKAVVQVR QKTLHKKTFY YLEQLILKYG
     MHQNTLRIKE IHDGLDFYYS SKQHAQKMVE FLQCTVPTRY KASQRLISQD IHSNTYNYKS
     TFSVEIVPIC KDNVVCLSPK LAQSLGNMNQ ICVCIRVTSV IHLIDPNTLQ VADIDGNTFW
     SHPFNSLCHP KQLEEFIVME CSIVQDIKRS AGAGMISKKH TLGEVWVQKT SEMNTDKQYF
     CRTHLGHLLN PGDLVLGFDL VNCNLNDEHV NKMKSDRVPD VVLIKKSYDR TRRQRRRNWK
     LKELARDREN TDTDDERQYQ DFLEDLEEDE AIRKNVNIYR DSTIPVESDT DDEGAPRISL
     AEMLEDLHIS QDATGGEGES MMT