NMD3_CHATD
ID NMD3_CHATD Reviewed; 518 AA.
AC G0S488;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 16-MAR-2016, sequence version 2.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=60S ribosomal export protein NMD3;
GN Name=NMD3; ORFNames=CTHT_0031110;
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=759272;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
CC -!- FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the
CC 60S ribosomal subunit. {ECO:0000250|UniProtKB:P38861}.
CC -!- SUBUNIT: Associates with the 60S ribosomal subunit.
CC {ECO:0000250|UniProtKB:P38861}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P38861}.
CC Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P38861}. Note=Shuttles
CC between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.
CC {ECO:0000250|UniProtKB:P38861}.
CC -!- SIMILARITY: Belongs to the NMD3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EGS21262.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; GL988041; EGS21262.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_006693558.1; XM_006693495.1.
DR AlphaFoldDB; G0S488; -.
DR SMR; G0S488; -.
DR STRING; 759272.G0S488; -.
DR EnsemblFungi; EGS21262; EGS21262; CTHT_0031110.
DR GeneID; 18257149; -.
DR KEGG; cthr:CTHT_0031110; -.
DR eggNOG; KOG2613; Eukaryota.
DR eggNOG; KOG4234; Eukaryota.
DR HOGENOM; CLU_018005_0_0_1; -.
DR OrthoDB; 734666at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR039768; Nmd3.
DR InterPro; IPR007064; Nmd3_N.
DR PANTHER; PTHR12746; PTHR12746; 1.
DR Pfam; PF04981; NMD3; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Nucleus; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..518
FT /note="60S ribosomal export protein NMD3"
FT /id="PRO_0000435818"
FT REGION 473..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 410..427
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:P38861"
FT MOTIF 502..511
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250|UniProtKB:P38861"
FT COMPBIAS 487..518
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 59027 MW; 554D232DDB004CE6 CRC64;
MDLDSPMGMA PMMGTARTGA TILCCNCGVP IDGTSSAGAL CYDCIKSTVD ISQGIQREGT
LHFCRDCERW LMPPSTWVAA APESRELLSL CLKRLRNLGR VRIIDARFVW TEPHSRRIKV
KITIQDQVSD GVLMQQSFEV VYVVAYQQCR ECAKSYTANV WRAVVQVRQK VTHKRTFLLL
EQLILKHQAH KDTINIKEEK DGVDFFFAQR NQAEAFVHFL KSVVPITLKD SRHLISQDTH
TGDKQYKFTY SAEIIPICRD DLVALPLKLA KQIGNIPPLC LCYRIGTAVY LLDPNTLHTA
ELSSDVYWRQ PFRPLADATS MVEFIVMDIE ATGIRKGKWV LAEVTVARAS DLGVNDNVYF
TRTHLGHLLH PGDSVMGYML TGTNFNSDTF DAIENSRQYG STIPDVVLVK KHYPNRRRNR
RRNWKLKRLP KDEGELLPKA TDQARMDDEY EAFLRDVEED EELRATLALY KNTRKTKKPQ
QDADAMSIAE TEDDDDGPKI SMDELLDDFE DLDIQDDQ