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NMD3_CHATD
ID   NMD3_CHATD              Reviewed;         518 AA.
AC   G0S488;
DT   16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-MAR-2016, sequence version 2.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=60S ribosomal export protein NMD3;
GN   Name=NMD3; ORFNames=CTHT_0031110;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the
CC       60S ribosomal subunit. {ECO:0000250|UniProtKB:P38861}.
CC   -!- SUBUNIT: Associates with the 60S ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P38861}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P38861}.
CC       Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P38861}. Note=Shuttles
CC       between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.
CC       {ECO:0000250|UniProtKB:P38861}.
CC   -!- SIMILARITY: Belongs to the NMD3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EGS21262.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; GL988041; EGS21262.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_006693558.1; XM_006693495.1.
DR   AlphaFoldDB; G0S488; -.
DR   SMR; G0S488; -.
DR   STRING; 759272.G0S488; -.
DR   EnsemblFungi; EGS21262; EGS21262; CTHT_0031110.
DR   GeneID; 18257149; -.
DR   KEGG; cthr:CTHT_0031110; -.
DR   eggNOG; KOG2613; Eukaryota.
DR   eggNOG; KOG4234; Eukaryota.
DR   HOGENOM; CLU_018005_0_0_1; -.
DR   OrthoDB; 734666at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR039768; Nmd3.
DR   InterPro; IPR007064; Nmd3_N.
DR   PANTHER; PTHR12746; PTHR12746; 1.
DR   Pfam; PF04981; NMD3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Nucleus; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..518
FT                   /note="60S ribosomal export protein NMD3"
FT                   /id="PRO_0000435818"
FT   REGION          473..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           410..427
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:P38861"
FT   MOTIF           502..511
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:P38861"
FT   COMPBIAS        487..518
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  59027 MW;  554D232DDB004CE6 CRC64;
     MDLDSPMGMA PMMGTARTGA TILCCNCGVP IDGTSSAGAL CYDCIKSTVD ISQGIQREGT
     LHFCRDCERW LMPPSTWVAA APESRELLSL CLKRLRNLGR VRIIDARFVW TEPHSRRIKV
     KITIQDQVSD GVLMQQSFEV VYVVAYQQCR ECAKSYTANV WRAVVQVRQK VTHKRTFLLL
     EQLILKHQAH KDTINIKEEK DGVDFFFAQR NQAEAFVHFL KSVVPITLKD SRHLISQDTH
     TGDKQYKFTY SAEIIPICRD DLVALPLKLA KQIGNIPPLC LCYRIGTAVY LLDPNTLHTA
     ELSSDVYWRQ PFRPLADATS MVEFIVMDIE ATGIRKGKWV LAEVTVARAS DLGVNDNVYF
     TRTHLGHLLH PGDSVMGYML TGTNFNSDTF DAIENSRQYG STIPDVVLVK KHYPNRRRNR
     RRNWKLKRLP KDEGELLPKA TDQARMDDEY EAFLRDVEED EELRATLALY KNTRKTKKPQ
     QDADAMSIAE TEDDDDGPKI SMDELLDDFE DLDIQDDQ
 
 
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