ID   NMD3_DANRE              Reviewed;         505 AA.
AC   Q5BLF0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=60S ribosomal export protein NMD3;
GN   Name=nmd3; Synonyms=nmd3l;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the
CC       60S ribosomal subunit. {ECO:0000250|UniProtKB:Q96D46}.
CC   -!- SUBUNIT: Associates with pre-60S ribosomal particles.
CC       {ECO:0000250|UniProtKB:Q96D46}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96D46}. Nucleus
CC       {ECO:0000250|UniProtKB:Q96D46}. Note=Shuttles between the
CC       nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner.
CC       {ECO:0000250|UniProtKB:Q96D46}.
CC   -!- SIMILARITY: Belongs to the NMD3 family. {ECO:0000305}.
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DR   EMBL; BC090467; AAH90467.1; -; mRNA.
DR   RefSeq; NP_001013587.1; NM_001013569.2.
DR   AlphaFoldDB; Q5BLF0; -.
DR   SMR; Q5BLF0; -.
DR   STRING; 7955.ENSDARP00000012858; -.
DR   PaxDb; Q5BLF0; -.
DR   PRIDE; Q5BLF0; -.
DR   Ensembl; ENSDART00000021299; ENSDARP00000012858; ENSDARG00000015676.
DR   GeneID; 541444; -.
DR   KEGG; dre:541444; -.
DR   CTD; 51068; -.
DR   ZFIN; ZDB-GENE-050320-149; nmd3.
DR   eggNOG; KOG2613; Eukaryota.
DR   GeneTree; ENSGT00390000005104; -.
DR   HOGENOM; CLU_027444_2_0_1; -.
DR   InParanoid; Q5BLF0; -.
DR   OMA; ILVKKHY; -.
DR   OrthoDB; 734666at2759; -.
DR   PhylomeDB; Q5BLF0; -.
DR   TreeFam; TF105744; -.
DR   PRO; PR:Q5BLF0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 15.
DR   Bgee; ENSDARG00000015676; Expressed in gastrula and 31 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR   InterPro; IPR039768; Nmd3.
DR   InterPro; IPR007064; Nmd3_N.
DR   PANTHER; PTHR12746; PTHR12746; 1.
DR   Pfam; PF04981; NMD3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..505
FT                   /note="60S ribosomal export protein NMD3"
FT                   /id="PRO_0000323564"
FT   REGION          467..505
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..481
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  57731 MW;  DC42A5F6212C13A3 CRC64;
     MEYMQAPPSS SHGNILCCTC GVPIPPNPAN MCVSCLRTQV DISEGIPKQV TIHFCRQCER
     YLQPPGSWVQ CALESRELLA LCLKKLKASM SKVRLIDAGF LWTEPHSKRI KIKLTIQKEV
     MNGAILQQVF TVEFVVQGQM CEDCHRVEAK DFWKAVVQVR QKTVHKKTFY YLEQLILKHK
     LHQNTVRIKE IHEGIDFYYA TKQHAQKMVD FLQCTVPCRS KASQRLISHD VHSNTYNYKS
     TFSVEIVPVC KDNVVCLSPR LAQSLGNMGQ VCVCVRVTSS IHLIDPNTLQ IAEVDGSTFW
     RHPFNSLCSP RQLEEFIIMD IDIIRDQRLG AGAGLKSNKH TLAEVWVQKT SEMDSSHQYH
     CRTFMGHLLN IGDLVLGFDF ANANINDEFL NKMNPQHVPD VVLIKKSYDR MKRARKRVWK
     LKEMDREKDA ADTDDERQYT EFLEDLEEDE MLRKNINIFR DASKIPVEES DTDDDGAPRI
     SLAEMLEDLS LSDATGGEGA DMMTD