ID   NMD3_DICDI              Reviewed;         530 AA.
AC   Q55BF2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=60S ribosomal export protein NMD3;
GN   Name=nmd3; ORFNames=DDB_G0271306;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Acts as an adapter for the xpo1-mediated export of the 60S
CC       ribosomal subunit. {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the 60S ribosomal subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleoplasm
CC       {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm in a
CC       xpo1-dependent manner. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NMD3 family. {ECO:0000305}.
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DR   EMBL; AAFI02000006; EAL71783.1; -; Genomic_DNA.
DR   RefSeq; XP_645660.1; XM_640568.1.
DR   AlphaFoldDB; Q55BF2; -.
DR   SMR; Q55BF2; -.
DR   STRING; 44689.DDB0302495; -.
DR   PaxDb; Q55BF2; -.
DR   EnsemblProtists; EAL71783; EAL71783; DDB_G0271306.
DR   GeneID; 8617852; -.
DR   KEGG; ddi:DDB_G0271306; -.
DR   dictyBase; DDB_G0271306; nmd3.
DR   eggNOG; KOG2613; Eukaryota.
DR   HOGENOM; CLU_027444_2_0_1; -.
DR   InParanoid; Q55BF2; -.
DR   OMA; ILVKKHY; -.
DR   PhylomeDB; Q55BF2; -.
DR   PRO; PR:Q55BF2; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISS:dictyBase.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR   GO; GO:0043023; F:ribosomal large subunit binding; ISS:dictyBase.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; ISS:dictyBase.
DR   InterPro; IPR039768; Nmd3.
DR   InterPro; IPR007064; Nmd3_N.
DR   PANTHER; PTHR12746; PTHR12746; 1.
DR   Pfam; PF04981; NMD3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..530
FT                   /note="60S ribosomal export protein NMD3"
FT                   /id="PRO_0000323567"
FT   REGION          497..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        498..530
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   530 AA;  61005 MW;  1AFEBC5F60941925 CRC64;
     MEYIPQVKQA NILCCMCGVL IPANPSNMCV DCIKSQVDIT EGIPKQLTIQ WCRGCARYLQ
     PPNHWAIAEL ESRELLTICI KRIKGLNKVK LVDAGWVWTE PHSKRLKVKL TIQKEVFTSA
     ILQQIFIIEF IVQGQQCDKC QKFEAKDTWN SVVQLRQKVD HKRTFLYIEQ LILKHNAHSQ
     TLNIKEKPDG LDFFFSNRNH AMKFVEFISA ITPVKTKKSE QLISSDEQNN AANYKYTFSV
     EIVPLSKDDI VCLPPKIAHQ LGNMGPLVVV TKVSNLIHFI DPNTLHTGEI SALTFWNSPF
     RALSSYKQLV EFTVLDVNLT GATRGRYALS DIQLMRSADF GANDNIYDIR SHLGNILNPG
     DLALGYDVAS SNFPDSDLAG MKKNQQLPDF VLVKKTYPSK NDFRFKRHWY FKEIPKEGIE
     NPKKFEIDQM ERDREEFLRE IEADPELRSK INIYKEADAA NILQQRIKKM QEHGIDEDAI
     KEELALDGLL DDMVNNLTIN DEEFEDEEDQ EGEDDDEEYD DEDEDDDMME