ID   NMD3_PONAB              Reviewed;         503 AA.
AC   Q5RC82;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=60S ribosomal export protein NMD3;
GN   Name=NMD3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the
CC       60S ribosomal subunit. {ECO:0000250|UniProtKB:Q96D46}.
CC   -!- SUBUNIT: Found in a 60S ribosomal subunit export complex with RAN and
CC       XPO1. Interacts with XPO1. Associates with pre-60S ribosomal particles.
CC       {ECO:0000250|UniProtKB:Q96D46}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96D46}. Nucleus
CC       {ECO:0000250|UniProtKB:Q96D46}. Note=Shuttles between the
CC       nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner.
CC       {ECO:0000250|UniProtKB:Q96D46}.
CC   -!- SIMILARITY: Belongs to the NMD3 family. {ECO:0000305}.
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DR   EMBL; CR858398; CAH90625.1; -; mRNA.
DR   RefSeq; NP_001127311.1; NM_001133839.1.
DR   AlphaFoldDB; Q5RC82; -.
DR   SMR; Q5RC82; -.
DR   STRING; 9601.ENSPPYP00000015946; -.
DR   GeneID; 100174372; -.
DR   KEGG; pon:100174372; -.
DR   CTD; 51068; -.
DR   eggNOG; KOG2613; Eukaryota.
DR   InParanoid; Q5RC82; -.
DR   OrthoDB; 734666at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR039768; Nmd3.
DR   InterPro; IPR007064; Nmd3_N.
DR   PANTHER; PTHR12746; PTHR12746; 1.
DR   Pfam; PF04981; NMD3; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..503
FT                   /note="60S ribosomal export protein NMD3"
FT                   /id="PRO_0000323563"
FT   REGION          425..503
FT                   /note="Necessary for the nuclear export of the 60S
FT                   ribosomal subunit"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOTIF           405..422
FT                   /note="Nuclear and nucleolar localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOTIF           480..489
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOD_RES         258
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOD_RES         433
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOD_RES         468
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
FT   MOD_RES         470
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96D46"
SQ   SEQUENCE   503 AA;  57639 MW;  E3CC81F5B38CF8DF CRC64;
     MEYMTESTDR SPGHILCCEC GVPISPNPAN ICVACLRSKV DISQGIPKQV SISFCKQCQR
     YFQPPGTWIQ CALESRELLA LCLKKIKAPL SKVRLVDAGF VWTEPHSKRL KVKLTVQKEV
     MNGAILQQVF VVDYVVQSQM CGDCHRVEAK DFWKAVIQVR QKTLHKKTFY HLEQLILKYG
     MHQNTLRIKE IHDGLDFYYS SKQHAQKMVE FLQCTVPCRY KASQRLISQD IHSNTYNYKS
     TFSVEIVPIC KDNVVCLSPK LAQSLGNMNQ ICVCIRVTSA IHLIDPNTLQ VADIDGSTFW
     SHPFNSLCHP KQLEEFIVME CSIVRDIKRA AGAGMISKKH TLGEVWVQKT SEMNTDKQYF
     CRTHLGHLLN PGDLVLGFDL ANCNLNDEHV NKMNSDRVPD VVLIKKSYDR TKRQRRRNWK
     LKELAREREN MDTDDERQYQ DFLEDLEEDE AIRKNVNIYR DSAIPVESDT DDEGAPRISL
     AEMLEDLHIS QDATGEEGAS MMT