ID   NMD4_CANAL              Reviewed;         398 AA.
AC   Q5AM50; A0A1D8PGI4; Q5ALQ0;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Nonsense-mediated decay protein 4;
GN   Name=NMD4; OrderedLocusNames=CAALFM_C202090WA;
GN   ORFNames=CaO19.1525, CaO19.9101;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in nonsense-mediated decay of mRNAs containing
CC       premature stop codons. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CP017624; AOW27249.1; -; Genomic_DNA.
DR   RefSeq; XP_722569.1; XM_717476.2.
DR   AlphaFoldDB; Q5AM50; -.
DR   GeneID; 3635854; -.
DR   KEGG; cal:CAALFM_C202090WA; -.
DR   CGD; CAL0000184115; orf19.9101.
DR   VEuPathDB; FungiDB:C2_02090W_A; -.
DR   eggNOG; ENOG502S5VM; Eukaryota.
DR   HOGENOM; CLU_049919_0_0_1; -.
DR   InParanoid; Q5AM50; -.
DR   OrthoDB; 1295045at2759; -.
DR   PRO; PR:Q5AM50; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   InterPro; IPR002716; PIN_dom.
DR   Pfam; PF13638; PIN_4; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..398
FT                   /note="Nonsense-mediated decay protein 4"
FT                   /id="PRO_0000096875"
FT   REGION          327..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   398 AA;  46338 MW;  CA4C71EF1B9E154A CRC64;
     MSLELSSNES EDNFRDELVD ISGQVSKKPI NIDSRQVRLI LDHTAFVRGI GNIKRWFNEE
     YINSNTTRSN EIINLNIYIP TYTLHEFDFV KKGTSISATN AREAIRFIDN YLENEVEMNS
     DKIQYNLILE SPQDNVPSWN KCNHYKVHSP KIKEFPNYKT KFDSSLIGQT PNVNEDSEFN
     ENFDNALTFN QRNKLNDIQY ENSASYQNAI ANSDNLAEMP VRLRYLIRSC IYKRFIETKK
     PKIKNEIEDW KLVTEDPITK IWAKSYGIDC LNVNEAELLI FQNYDVNSFR LYNPYANDGD
     DFDPSTNILQ NTIDTTLYSY SSVQDEPVTS NYRGKNNRGR NNRGRRGNKR RERERWPLST
     DAVVSEERNE SGTGFIKKEK FGAINYAPRG QGELWRPG