ID   NMD4_DEBHA              Reviewed;         416 AA.
AC   Q6BJE2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Nonsense-mediated decay protein 4;
GN   Name=NMD4; OrderedLocusNames=DEHA2G03080g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in nonsense-mediated decay of mRNAs containing
CC       premature stop codons. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CR382139; CAG90127.1; -; Genomic_DNA.
DR   RefSeq; XP_461679.1; XM_461679.1.
DR   AlphaFoldDB; Q6BJE2; -.
DR   EnsemblFungi; CAG90127; CAG90127; DEHA2G03080g.
DR   GeneID; 2904547; -.
DR   KEGG; dha:DEHA2G03080g; -.
DR   VEuPathDB; FungiDB:DEHA2G03080g; -.
DR   eggNOG; ENOG502S5VM; Eukaryota.
DR   HOGENOM; CLU_049919_0_0_1; -.
DR   InParanoid; Q6BJE2; -.
DR   OMA; DIQYENS; -.
DR   OrthoDB; 1295045at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   InterPro; IPR002716; PIN_dom.
DR   Pfam; PF13638; PIN_4; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..416
FT                   /note="Nonsense-mediated decay protein 4"
FT                   /id="PRO_0000096877"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   416 AA;  48079 MW;  50548EE3903D7787 CRC64;
     MSLYPYNSDE DEARKNSNYH DFDELVPSEE IENASKPSDT FPGRKSRNIN VILDHSAFVR
     GIGNIKRWFN QEYIKAHIDP NADEEIYLNI YIPSYTLHEF DYVKKGTSMM ATNAREAIRF
     IDKIFEKELN GEDETDPMNP DSKPGKKSII YDLYIESPNE SGPSWSECLN YKVHSPKIKE
     FPNFKTKFDS NLIGQHPIPQ GESLESHNSF DETNYNNSSA YKQNNKLNDI QYENSQSYQN
     ALANADELAE MPTRLRYLIR SCIYKRFIER KSFNSPLEEW KLVTEDPITK VWAKSFGIDC
     MNVNEAELLI FQSYDINQYQ LYDPRHTFSV DDESHAPNSI LQNTIDTTLY SYTKIDRPSK
     SKNKNKNKNT KKSTKPKQIN GVVSDGCTGA NGDFVKKERF DAINYAPRGT GDLWKP