ID   NMD4_KLULA              Reviewed;         244 AA.
AC   Q6CVZ8;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Nonsense-mediated decay protein 4;
GN   Name=NMD4; OrderedLocusNames=KLLA0B08107g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in nonsense-mediated decay of mRNAs containing
CC       premature stop codons. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CR382122; CAH02284.1; -; Genomic_DNA.
DR   RefSeq; XP_451891.1; XM_451891.1.
DR   PDB; 7QHY; X-ray; 2.45 A; A/B=2-244.
DR   PDBsum; 7QHY; -.
DR   AlphaFoldDB; Q6CVZ8; -.
DR   STRING; 28985.XP_451891.1; -.
DR   EnsemblFungi; CAH02284; CAH02284; KLLA0_B08107g.
DR   GeneID; 2896883; -.
DR   KEGG; kla:KLLA0_B08107g; -.
DR   eggNOG; ENOG502RYBU; Eukaryota.
DR   HOGENOM; CLU_1273151_0_0_1; -.
DR   InParanoid; Q6CVZ8; -.
DR   OMA; PTYTLKE; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..244
FT                   /note="Nonsense-mediated decay protein 4"
FT                   /id="PRO_0000096878"
SQ   SEQUENCE   244 AA;  28062 MW;  6EEFD37177063072 CRC64;
     MILNFIIDSS SFEKGLGNIA IWSKLNDPKL TINAYLPLFT IQELDFQRFK RKSVVAKRAL
     HFIDLLQDST SFKLHLEYPE LNEAISWNET VKLCQQNSHT SLSQHQISVI PIRFKKLLKS
     CYYKCHYKSH DLDEDIDHTN EKSDPDDKGW VLVTEDDTVR SLATQFQIPF ISVVEADAII
     NACIKDKSYV VNEKFSKTVI KKANKVKEQE DGKKVFVTDF KNDFLAPRAK SGELWTPTSA
     KNKS