ID   NMES1_HUMAN             Reviewed;          83 AA.
AC   Q9C002;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Normal mucosa of esophagus-specific gene 1 protein;
DE   AltName: Full=Protein FOAP-11;
GN   Name=NMES1; Synonyms=C15orf48;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX   PubMed=12209954; DOI=10.1002/ijc.10600;
RA   Zhou J., Wang H., Lu A., Hu G., Luo A., Ding F., Zhang J., Wang X., Wu M.,
RA   Liu Z.;
RT   "A novel gene, NMES1, downregulated in human esophageal squamous cell
RT   carcinoma.";
RL   Int. J. Cancer 101:311-316(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Macrophage;
RA   Fujii Y., Takayama K., Tsuritani K., Yajima Y., Amemiya T., Ukai Y.,
RA   Naito K., Kawaguhci A.;
RT   "Homo sapiens mRNA for FOAP-11 protein, complete cds.";
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9C002; P42858: HTT; NbExp=3; IntAct=EBI-3905285, EBI-466029;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12209954}.
CC   -!- TISSUE SPECIFICITY: Expressed mainly in stomach, placenta, small
CC       intestine and colon, as well as in normal mucosa of esophagus. Down-
CC       regulated in esophageal squamous cell carcinoma.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA4 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AF228422; AAK00708.1; -; mRNA.
DR   EMBL; AB026707; BAB61021.1; -; mRNA.
DR   EMBL; BC021173; AAH21173.1; -; mRNA.
DR   CCDS; CCDS10124.1; -.
DR   RefSeq; NP_115789.1; NM_032413.3.
DR   RefSeq; NP_922946.1; NM_197955.2.
DR   AlphaFoldDB; Q9C002; -.
DR   SMR; Q9C002; -.
DR   BioGRID; 124071; 140.
DR   IntAct; Q9C002; 177.
DR   STRING; 9606.ENSP00000341610; -.
DR   iPTMnet; Q9C002; -.
DR   PhosphoSitePlus; Q9C002; -.
DR   BioMuta; C15orf48; -.
DR   DMDM; 23396774; -.
DR   EPD; Q9C002; -.
DR   jPOST; Q9C002; -.
DR   MassIVE; Q9C002; -.
DR   MaxQB; Q9C002; -.
DR   PaxDb; Q9C002; -.
DR   PeptideAtlas; Q9C002; -.
DR   PRIDE; Q9C002; -.
DR   ProteomicsDB; 79935; -.
DR   TopDownProteomics; Q9C002; -.
DR   Antibodypedia; 56517; 36 antibodies from 10 providers.
DR   DNASU; 84419; -.
DR   Ensembl; ENST00000344300.3; ENSP00000341610.3; ENSG00000166920.13.
DR   Ensembl; ENST00000396650.7; ENSP00000379887.2; ENSG00000166920.13.
DR   GeneID; 84419; -.
DR   KEGG; hsa:84419; -.
DR   MANE-Select; ENST00000396650.7; ENSP00000379887.2; NM_197955.3; NP_922946.1.
DR   UCSC; uc001zvg.5; human.
DR   CTD; 84419; -.
DR   DisGeNET; 84419; -.
DR   GeneCards; C15orf48; -.
DR   HGNC; HGNC:29898; C15orf48.
DR   HPA; ENSG00000166920; Tissue enriched (intestine).
DR   MIM; 608409; gene.
DR   neXtProt; NX_Q9C002; -.
DR   OpenTargets; ENSG00000166920; -.
DR   PharmGKB; PA142672265; -.
DR   VEuPathDB; HostDB:ENSG00000166920; -.
DR   eggNOG; ENOG502STGR; Eukaryota.
DR   GeneTree; ENSGT00390000009277; -.
DR   HOGENOM; CLU_178748_0_0_1; -.
DR   InParanoid; Q9C002; -.
DR   OMA; ANPEPWE; -.
DR   OrthoDB; 1552648at2759; -.
DR   PhylomeDB; Q9C002; -.
DR   TreeFam; TF106383; -.
DR   PathwayCommons; Q9C002; -.
DR   SignaLink; Q9C002; -.
DR   BioGRID-ORCS; 84419; 5 hits in 1063 CRISPR screens.
DR   ChiTaRS; C15orf48; human.
DR   GenomeRNAi; 84419; -.
DR   Pharos; Q9C002; Tdark.
DR   PRO; PR:Q9C002; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q9C002; protein.
DR   Bgee; ENSG00000166920; Expressed in mucosa of transverse colon and 91 other tissues.
DR   ExpressionAtlas; Q9C002; baseline and differential.
DR   Genevisible; Q9C002; HS.
DR   GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   InterPro; IPR010530; B12D.
DR   PANTHER; PTHR14256; PTHR14256; 1.
DR   Pfam; PF06522; B12D; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..83
FT                   /note="Normal mucosa of esophagus-specific gene 1 protein"
FT                   /id="PRO_0000118823"
SQ   SEQUENCE   83 AA;  9617 MW;  21884FE8A009C039 CRC64;
     MSFFQLLMKR KELIPLVVFM TVAAGGASSF AVYSLWKTDV ILDRKKNPEP WETVDPTVPQ
     KLITINQQWK PIEELQNVQR VTK