ID   NMOR_PSEAE              Reviewed;         284 AA.
AC   Q9HWH8;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=HTH-type transcriptional regulator NmoR {ECO:0000305};
GN   Name=nmoR {ECO:0000303|PubMed:25384477};
GN   OrderedLocusNames=PA4203 {ECO:0000312|EMBL:AAG07590.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=25384477; DOI=10.1128/jb.01991-14;
RA   Vercammen K., Wei Q., Charlier D., Doetsch A., Hauessler S., Schulz S.,
RA   Salvi F., Gadda G., Spain J., Rybtke M.L., Tolker-Nielsen T., Dingemans J.,
RA   Ye L., Cornelis P.;
RT   "Pseudomonas aeruginosa LysR PA4203 regulator NmoR acts as a repressor of
RT   the PA4202 nmoA gene, encoding a nitronate monooxygenase.";
RL   J. Bacteriol. 197:1026-1039(2015).
CC   -!- FUNCTION: Represses its own transcription and the expression of nmoA, a
CC       nitronate monooxygenase. The nmoA-nmoR intergenic region is the sole
CC       direct binding site of NmoR across the P.aeruginosa PAO1 genome. Other
CC       genes seem also to be under negative control of NmoR, especially PA1225
CC       and the hemO gene. {ECO:0000269|PubMed:25384477}.
CC   -!- DISRUPTION PHENOTYPE: The PA1225 gene, encoding a quinone
CC       oxidoreductase, is the most highly up-regulated gene in cells lacking
CC       NmoR. {ECO:0000269|PubMed:25384477}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE004091; AAG07590.1; -; Genomic_DNA.
DR   PIR; H83119; H83119.
DR   RefSeq; NP_252892.1; NC_002516.2.
DR   RefSeq; WP_003114724.1; NZ_QZGE01000013.1.
DR   AlphaFoldDB; Q9HWH8; -.
DR   SMR; Q9HWH8; -.
DR   STRING; 208964.PA4203; -.
DR   PaxDb; Q9HWH8; -.
DR   PRIDE; Q9HWH8; -.
DR   EnsemblBacteria; AAG07590; AAG07590; PA4203.
DR   GeneID; 880443; -.
DR   KEGG; pae:PA4203; -.
DR   PATRIC; fig|208964.12.peg.4403; -.
DR   PseudoCAP; PA4203; -.
DR   HOGENOM; CLU_039613_6_1_6; -.
DR   InParanoid; Q9HWH8; -.
DR   OMA; AFERGCT; -.
DR   PhylomeDB; Q9HWH8; -.
DR   BioCyc; PAER208964:G1FZ6-4276-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..284
FT                   /note="HTH-type transcriptional regulator NmoR"
FT                   /id="PRO_0000445424"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   284 AA;  30730 MW;  F2DE547566761897 CRC64;
     MDLSSLEIFR AVAHEASVTR AAQRLQRAQS NVTTRIRQLE EDLGVELFLR DGKRMSLTER
     GSEFLAYAEQ LLALADEARQ SMHPAEPGGR LRLGSMESTA ASRLPALLAS YHKACPRVAL
     EVSTGTSHAL FDGVRARRLD CALVAAGPGW AGELDGSGLR GEPLFREELL MILPAEHPPV
     HDVAEVRLRT LAGFARGCTY RQLAEDSLGT PLTVQEVGSY HAILACVAAG ACVGVLPRSV
     LQLLGTPPLR SLPLAEVDTW LVWREGYATA AFERWRGVLG QAGD