ID   NMPC_ECOLI              Reviewed;         365 AA.
AC   P21420; P77189;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2003, sequence version 2.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Putative outer membrane porin protein NmpC;
DE   Flags: Precursor;
GN   Name=nmpC; Synonyms=phmA; OrderedLocusNames=b0553;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Mutant CS384;
RX   PubMed=3017988; DOI=10.1016/s0021-9258(18)67152-2;
RA   Blasband A.J., Marcotte W.R. Jr., Schnaitman C.A.;
RT   "Structure of the lc and nmpC outer membrane porin protein genes of
RT   lambdoid bacteriophage.";
RL   J. Biol. Chem. 261:12723-12732(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
RC   STRAIN=JL5502;
RX   PubMed=8057841; DOI=10.1111/j.1365-2958.1994.tb00997.x;
RA   Coll J.L., Heyde M., Portalier R.;
RT   "Expression of the nmpC gene of Escherichia coli K-12 is modulated by
RT   external pH. Identification of cis-acting regulatory sequences involved in
RT   this regulation.";
RL   Mol. Microbiol. 12:83-93(1994).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 347-365.
RC   STRAIN=K12;
RX   PubMed=8648624; DOI=10.1006/jmbi.1996.0185;
RA   Mahdi A.A., Sharples G.J., Mandal T.N., Lloyd R.G.;
RT   "Holliday junction resolvases encoded by homologous rusA genes in
RT   Escherichia coli K-12 and phage 82.";
RL   J. Mol. Biol. 257:561-573(1996).
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC       Note=When expressed in mutant CS384.
CC   -!- MISCELLANEOUS: Encoded by the cryptic lambdoid prophage DLP12.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene, as in E.coli K12 the
CC       nmpC open reading frame is interrupted by an IS5 insertion and
CC       generates a hybrid open reading frame that is not expressed. In strains
CC       which have undergone selection for suppressors of ompB mutations (for
CC       example, mutant strain CS384) nmpC is expressed. {ECO:0000305}.
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DR   EMBL; M13457; AAA23728.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; U82598; AAB40749.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; U00096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z35442; CAA84594.1; -; Genomic_DNA.
DR   EMBL; X92587; CAA63325.1; -; Genomic_DNA.
DR   PIR; A25647; MMECNC.
DR   AlphaFoldDB; P21420; -.
DR   SMR; P21420; -.
DR   IntAct; P21420; 1.
DR   MINT; P21420; -.
DR   TCDB; 1.B.1.1.4; the general bacterial porin (gbp) family.
DR   PRIDE; P21420; -.
DR   EchoBASE; EB0653; -.
DR   InParanoid; P21420; -.
DR   PhylomeDB; P21420; -.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001897; Porin_gammaproteobac.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00183; ECOLIPORIN.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   5: Uncertain;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Reference proteome;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..365
FT                   /note="Putative outer membrane porin protein NmpC"
FT                   /id="PRO_0000025248"
FT   CONFLICT        326
FT                   /note="N -> K (in Ref. 1; AAA23728)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   365 AA;  40302 MW;  6A0069D4847FB4FF CRC64;
     MKKLTVAISA VAASVLMAMS AQAAEIYNKD SNKLDLYGKV NAKHYFSSND ADDGDTTYAR
     LGFKGETQIN DQLTGFGQWE YEFKGNRAES QGSSKDKTRL AFAGLKFGDY GSIDYGRNYG
     VAYDIGAWTD VLPEFGGDTW TQTDVFMTQR ATGVATYRNN DFFGLVDGLN FAAQYQGKND
     RSDFDNYTEG NGDGFGFSAT YEYEGFGIGA TYAKSDRTDT QVNAGKVLPE VFASGKNAEV
     WAAGLKYDAN NIYLATTYSE TQNMTVFADH FVANKAQNFE AVAQYQFDFG LRPSVAYLQS
     KGKDLGVWGD QDLVKYVDVG ATYYFNKNMS TFVDYKINLL DKNDFTKALG VSTDDIVAVG
     LVYQF