ID   NMRL1_CHICK             Reviewed;         296 AA.
AC   Q5ZID0;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=NmrA-like family domain-containing protein 1;
GN   Name=NMRAL1; ORFNames=RCJMB04_27o15;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Redox sensor protein. Undergoes restructuring and subcellular
CC       redistribution in response to changes in intracellular NADPH/NADP(+)
CC       levels (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear
CC       region {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NmrA-type oxidoreductase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved Tyr residue in the active site triad of
CC       Ser-Tyr-Lys necessary for dehydrogenase activity, suggesting that it
CC       has no oxidoreductase activity. {ECO:0000305}.
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DR   EMBL; AJ720854; CAG32513.1; -; mRNA.
DR   RefSeq; NP_001025816.1; NM_001030645.1.
DR   AlphaFoldDB; Q5ZID0; -.
DR   SMR; Q5ZID0; -.
DR   STRING; 9031.ENSGALP00000012689; -.
DR   PaxDb; Q5ZID0; -.
DR   GeneID; 416672; -.
DR   KEGG; gga:416672; -.
DR   CTD; 57407; -.
DR   VEuPathDB; HostDB:geneid_416672; -.
DR   eggNOG; ENOG502QQEA; Eukaryota.
DR   HOGENOM; CLU_007383_8_2_1; -.
DR   InParanoid; Q5ZID0; -.
DR   OrthoDB; 707551at2759; -.
DR   PhylomeDB; Q5ZID0; -.
DR   PRO; PR:Q5ZID0; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR008030; NmrA-like.
DR   Pfam; PF05368; NmrA; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; NADP; Nucleus; Reference proteome.
FT   CHAIN           1..296
FT                   /note="NmrA-like family domain-containing protein 1"
FT                   /id="PRO_0000278206"
FT   BINDING         11..16
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         37..41
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         58..59
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         79..81
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         133
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         155..158
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   296 AA;  32689 MW;  B447DBF490A832B7 CRC64;
     MTSKKLIVVF GATGAQGGSV ARALLEDGAF AVRAVTRSPG RKEAAELRRR GAELMRADQD
     DERSLEEALT GAHGAFVVTN FWEHCSKEKE VAQGRRLADL SKRLGLQHVV YSGLENVKQL
     TKGRLEVLHF DGKGEVEEYF RAVNVPTTTI RLPFYYENFL SSFKPQKAPQ GDKLLLGLPM
     GDTPMDGMAV EDLGPIVLSL LKSPEQYIGQ VIGLSAGKLT VAEYAAAFSQ QTGKTVEDSK
     ITPEEYEKLG FPGAKELADM FRFYALKPDR NVELTMKLNP KARTFQQWLA DNKAAF