ID   NMRL1_DICDI             Reviewed;         302 AA.
AC   Q54LJ8;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=NmrA-like family domain-containing protein DDB_G0286605;
GN   ORFNames=DDB_G0286605;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
RX   PubMed=15470253; DOI=10.1128/ec.3.5.1241-1248.2004;
RA   Maruo T., Sakamoto H., Iranfar N., Fuller D., Morio T., Urushihara H.,
RA   Tanaka Y., Maeda M., Loomis W.F.;
RT   "Control of cell type proportioning in Dictyostelium discoideum by
RT   differentiation-inducing factor as determined by in situ hybridization.";
RL   Eukaryot. Cell 3:1241-1248(2004).
CC   -!- FUNCTION: May be a redox sensor protein. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in prespore cells.
CC       {ECO:0000269|PubMed:15470253}.
CC   -!- SIMILARITY: Belongs to the NmrA-type oxidoreductase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved Tyr residue in the active site triad of
CC       Ser-Tyr-Lys necessary for dehydrogenase activity, suggesting that it
CC       has no oxidoreductase activity. {ECO:0000305}.
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DR   EMBL; AAFI02000089; EAL64058.1; -; Genomic_DNA.
DR   RefSeq; XP_637563.1; XM_632471.1.
DR   AlphaFoldDB; Q54LJ8; -.
DR   SMR; Q54LJ8; -.
DR   STRING; 44689.DDB0231607; -.
DR   PaxDb; Q54LJ8; -.
DR   EnsemblProtists; EAL64058; EAL64058; DDB_G0286605.
DR   GeneID; 8625702; -.
DR   KEGG; ddi:DDB_G0286605; -.
DR   dictyBase; DDB_G0286605; -.
DR   eggNOG; ENOG502S10Y; Eukaryota.
DR   HOGENOM; CLU_007383_8_6_1; -.
DR   InParanoid; Q54LJ8; -.
DR   OMA; YYAPRME; -.
DR   PhylomeDB; Q54LJ8; -.
DR   PRO; PR:Q54LJ8; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR008030; NmrA-like.
DR   Pfam; PF05368; NmrA; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   NADP; Reference proteome.
FT   CHAIN           1..302
FT                   /note="NmrA-like family domain-containing protein
FT                   DDB_G0286605"
FT                   /id="PRO_0000393567"
FT   BINDING         9..14
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         35..39
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         56..57
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         78..80
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         130
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         157..160
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   302 AA;  34363 MW;  719CEEDCB6A22919 CRC64;
     MSKKVLVFGG TGYQGGSVVR ELLKDDSFKV ITLSRNPESE KCKELKKLGA DVIKCDESQP
     KEEIEKVMKG CDCVYLVTNS QGYCEKEIEY GIKVADVALK CGVKHFIFST VPGPNKLSNG
     KFKSPDLDNK VEIEQHIRQL SKSNPEFISS FVIAPWYFQN FINYYQPEKE SSTSDKYILK
     WACDPKVSLD YGDIDELGLL VREIFKNPIK FSGETVPFSS EILTPIQIVE IISKVTNKKV
     SYQFIDPVEY GKSYDLEVSL MLAFFNEYGG FNIYGGDRSI AHNIKKLTSF EEYLKKINYK
     LD