ID   NMS_BOVIN               Reviewed;         145 AA.
AC   Q0VBW8;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Neuromedin-S;
DE   Flags: Precursor;
GN   Name=NMS;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Implicated in the regulation of circadian rhythms through
CC       autocrine and/or paracrine actions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
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DR   EMBL; BC120470; AAI20471.1; -; mRNA.
DR   RefSeq; NP_001070990.1; NM_001077522.2.
DR   AlphaFoldDB; Q0VBW8; -.
DR   PaxDb; Q0VBW8; -.
DR   GeneID; 768331; -.
DR   KEGG; bta:768331; -.
DR   CTD; 129521; -.
DR   eggNOG; ENOG502SB16; Eukaryota.
DR   HOGENOM; CLU_090356_1_0_1; -.
DR   InParanoid; Q0VBW8; -.
DR   OrthoDB; 1542759at2759; -.
DR   TreeFam; TF338319; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR018070; Neuromedin-U_amidation-site.
DR   InterPro; IPR043253; NmS.
DR   PANTHER; PTHR32414; PTHR32414; 1.
DR   PROSITE; PS00967; NMU; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..64
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000262475"
FT   PROPEP          65..100
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000262476"
FT   PROPEP          101..103
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000262477"
FT   PEPTIDE         104..136
FT                   /note="Neuromedin-S"
FT                   /id="PRO_0000262478"
FT   PROPEP          139..145
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000262479"
FT   MOD_RES         136
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   145 AA;  16986 MW;  79BD16B164EE551F CRC64;
     MKYLAQFPSI LAIYCFCLLQ IPSSGFPRPL ADASDGLDIV KFEQMAYWAS LSRQPKDNQD
     IYKRFLFHYS RTQEPAHPVK TGFPPVHPLM RLAAKLADRR MKTFWRRDSR ATAADFTKKD
     YTATLGRPFF LFRPRNGRNL DFDTW