NMS_HUMAN
ID NMS_HUMAN Reviewed; 153 AA.
AC Q5H8A3;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Neuromedin-S;
DE Flags: Precursor;
GN Name=NMS;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=15635449; DOI=10.1038/sj.emboj.7600526;
RA Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M.,
RA Kangawa K.;
RT "Identification of neuromedin S and its possible role in the mammalian
RT circadian oscillator system.";
RL EMBO J. 24:325-335(2005).
CC -!- FUNCTION: Implicated in the regulation of circadian rhythms through
CC autocrine and/or paracrine actions. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
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DR EMBL; AB164464; BAD89024.1; -; mRNA.
DR CCDS; CCDS33259.1; -.
DR RefSeq; NP_001011717.1; NM_001011717.1.
DR AlphaFoldDB; Q5H8A3; -.
DR BioGRID; 126194; 40.
DR STRING; 9606.ENSP00000366061; -.
DR BioMuta; NMS; -.
DR DMDM; 74722605; -.
DR PaxDb; Q5H8A3; -.
DR PRIDE; Q5H8A3; -.
DR TopDownProteomics; Q5H8A3; -.
DR Antibodypedia; 48800; 117 antibodies from 21 providers.
DR DNASU; 129521; -.
DR Ensembl; ENST00000376865.1; ENSP00000366061.1; ENSG00000204640.1.
DR GeneID; 129521; -.
DR KEGG; hsa:129521; -.
DR MANE-Select; ENST00000376865.1; ENSP00000366061.1; NM_001011717.1; NP_001011717.1.
DR UCSC; uc002tan.1; human.
DR CTD; 129521; -.
DR DisGeNET; 129521; -.
DR GeneCards; NMS; -.
DR HGNC; HGNC:32203; NMS.
DR HPA; ENSG00000204640; Tissue enriched (brain).
DR MIM; 619337; gene.
DR neXtProt; NX_Q5H8A3; -.
DR OpenTargets; ENSG00000204640; -.
DR PharmGKB; PA142671260; -.
DR VEuPathDB; HostDB:ENSG00000204640; -.
DR eggNOG; ENOG502SB16; Eukaryota.
DR GeneTree; ENSGT00510000049213; -.
DR HOGENOM; CLU_090356_1_0_1; -.
DR InParanoid; Q5H8A3; -.
DR OMA; CMLPIPS; -.
DR OrthoDB; 1542759at2759; -.
DR PhylomeDB; Q5H8A3; -.
DR TreeFam; TF338319; -.
DR PathwayCommons; Q5H8A3; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q5H8A3; -.
DR SIGNOR; Q5H8A3; -.
DR BioGRID-ORCS; 129521; 10 hits in 1055 CRISPR screens.
DR GenomeRNAi; 129521; -.
DR Pharos; Q5H8A3; Tbio.
DR PRO; PR:Q5H8A3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q5H8A3; protein.
DR Bgee; ENSG00000204640; Expressed in hypothalamus and 19 other tissues.
DR ExpressionAtlas; Q5H8A3; baseline and differential.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR GO; GO:0045475; P:locomotor rhythm; IEA:Ensembl.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR018070; Neuromedin-U_amidation-site.
DR InterPro; IPR043253; NmS.
DR PANTHER; PTHR32414; PTHR32414; 1.
DR PROSITE; PS00967; NMU; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PROPEP 27..69
FT /id="PRO_0000262480"
FT PROPEP 70..105
FT /id="PRO_0000262481"
FT PROPEP 106..108
FT /id="PRO_0000262482"
FT PEPTIDE 109..141
FT /note="Neuromedin-S"
FT /id="PRO_0000262483"
FT PROPEP 144..153
FT /id="PRO_0000262484"
FT MOD_RES 141
FT /note="Asparagine amide"
FT /evidence="ECO:0000250"
FT VARIANT 6
FT /note="P -> S (in dbSNP:rs13411940)"
FT /id="VAR_029495"
SQ SEQUENCE 153 AA; 17731 MW; 93B65FB17876C600 CRC64;
MKHLRPQFPL ILAIYCFCML QIPSSGFPQP LADPSDGLDI VQLEQLAYCL SQWAPLSRQP
KDNQDIYKRF LFHYSRTQEA THPVKTGFPP VHPLMHLAAK LANRRMKRIL QRGSGTAAVD
FTKKDHTATW GRPFFLFRPR NGRNIEDEAQ IQW