NMS_MOUSE
ID NMS_MOUSE Reviewed; 153 AA.
AC Q5H8A1; B2RSM4;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Neuromedin-S;
DE Flags: Precursor;
GN Name=Nms;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=15635449; DOI=10.1038/sj.emboj.7600526;
RA Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M.,
RA Kangawa K.;
RT "Identification of neuromedin S and its possible role in the mammalian
RT circadian oscillator system.";
RL EMBO J. 24:325-335(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Implicated in the regulation of circadian rhythms through
CC autocrine and/or paracrine actions. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
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DR EMBL; AB164466; BAD89026.1; -; mRNA.
DR EMBL; BC138922; AAI38923.1; -; mRNA.
DR CCDS; CCDS14902.1; -.
DR RefSeq; NP_001011684.3; NM_001011684.2.
DR AlphaFoldDB; Q5H8A1; -.
DR BioGRID; 241148; 1.
DR STRING; 10090.ENSMUSP00000085346; -.
DR PaxDb; Q5H8A1; -.
DR PRIDE; Q5H8A1; -.
DR Antibodypedia; 48800; 117 antibodies from 21 providers.
DR DNASU; 433292; -.
DR Ensembl; ENSMUST00000088029; ENSMUSP00000085346; ENSMUSG00000067604.
DR GeneID; 433292; -.
DR KEGG; mmu:433292; -.
DR UCSC; uc007atb.1; mouse.
DR CTD; 129521; -.
DR MGI; MGI:3583618; Nms.
DR VEuPathDB; HostDB:ENSMUSG00000067604; -.
DR eggNOG; ENOG502SB16; Eukaryota.
DR GeneTree; ENSGT00510000049213; -.
DR InParanoid; Q5H8A1; -.
DR OMA; CMLPIPS; -.
DR OrthoDB; 1542759at2759; -.
DR PhylomeDB; Q5H8A1; -.
DR TreeFam; TF338319; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 433292; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q5H8A1; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q5H8A1; protein.
DR Bgee; ENSMUSG00000067604; Expressed in neural tube and 3 other tissues.
DR ExpressionAtlas; Q5H8A1; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR GO; GO:0045475; P:locomotor rhythm; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISO:MGI.
DR InterPro; IPR018070; Neuromedin-U_amidation-site.
DR InterPro; IPR043253; NmS.
DR PANTHER; PTHR32414; PTHR32414; 1.
DR PROSITE; PS00967; NMU; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PROPEP 27..69
FT /id="PRO_0000262485"
FT PROPEP 70..105
FT /id="PRO_0000262486"
FT PROPEP 106..108
FT /id="PRO_0000262487"
FT PEPTIDE 109..144
FT /note="Neuromedin-S"
FT /id="PRO_0000262488"
FT PROPEP 147..153
FT /id="PRO_0000262489"
FT MOD_RES 144
FT /note="Asparagine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 153 AA; 17883 MW; B54932C24D2A4507 CRC64;
MKHPLPHYSP ILFIYCFCML QIPSSGASPP LADSPDGLDI VDPERLAYFL KQREIHSNQP
KENQDVYKRF LFHYSRTRKP THPVSAEFAP VHPLMRLAAK LASRRMKRLP RLLRLDSRMA
TVDFPKKDPT TSLGRPFFLF RPRNGRYTDN NFQ
