NMS_RAT
ID NMS_RAT Reviewed; 152 AA.
AC Q5H8A2;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Neuromedin-S;
DE Flags: Precursor;
GN Name=Nms;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 109-144, FUNCTION, TISSUE
RP SPECIFICITY, INDUCTION, AND PROTEOLYTIC PROCESSING.
RC TISSUE=Brain;
RX PubMed=15635449; DOI=10.1038/sj.emboj.7600526;
RA Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M.,
RA Kangawa K.;
RT "Identification of neuromedin S and its possible role in the mammalian
RT circadian oscillator system.";
RL EMBO J. 24:325-335(2005).
CC -!- FUNCTION: Implicated in the regulation of circadian rhythms through
CC autocrine and/or paracrine actions. Stimulates the contraction of
CC rectum and elevation of blood pressure. {ECO:0000269|PubMed:15635449}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the CNS, spleen and testis.
CC Specifically expressed in the suprachiasmatic nuclei (SCN) of the
CC hypothalamus. {ECO:0000269|PubMed:15635449}.
CC -!- INDUCTION: Expression has a diurnal peak under light/dark cycling, but
CC remains stable under constant darkness. {ECO:0000269|PubMed:15635449}.
CC -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
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DR EMBL; AB164465; BAD89025.1; -; mRNA.
DR RefSeq; NP_001012233.1; NM_001012233.1.
DR AlphaFoldDB; Q5H8A2; -.
DR STRING; 10116.ENSRNOP00000056345; -.
DR PaxDb; Q5H8A2; -.
DR Ensembl; ENSRNOT00000059587; ENSRNOP00000056345; ENSRNOG00000038979.
DR GeneID; 497196; -.
DR KEGG; rno:497196; -.
DR UCSC; RGD:1359122; rat.
DR CTD; 129521; -.
DR RGD; 1359122; NMS.
DR eggNOG; ENOG502SB16; Eukaryota.
DR GeneTree; ENSGT00510000049213; -.
DR HOGENOM; CLU_090356_1_0_1; -.
DR InParanoid; Q5H8A2; -.
DR OMA; CMLPIPS; -.
DR OrthoDB; 1542759at2759; -.
DR PhylomeDB; Q5H8A2; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:Q5H8A2; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000038979; Expressed in testis.
DR ExpressionAtlas; Q5H8A2; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IDA:MGI.
DR GO; GO:0045475; P:locomotor rhythm; IDA:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
DR InterPro; IPR018070; Neuromedin-U_amidation-site.
DR InterPro; IPR043253; NmS.
DR PANTHER; PTHR32414; PTHR32414; 1.
DR PROSITE; PS00967; NMU; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PROPEP 27..69
FT /id="PRO_0000262490"
FT PROPEP 70..105
FT /id="PRO_0000262491"
FT PROPEP 106..108
FT /evidence="ECO:0000269|PubMed:15635449"
FT /id="PRO_0000262492"
FT PEPTIDE 109..144
FT /note="Neuromedin-S"
FT /id="PRO_0000262493"
FT PROPEP 147..152
FT /id="PRO_0000262494"
FT MOD_RES 144
FT /note="Asparagine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 152 AA; 17572 MW; F60C68007C5D7314 CRC64;
MKHPFPQFPP ILVIYCFCML QIPSSGASPP LAGPPDGLDA VDPERLAHFL NQRETCSNQP
KESRDVYKRF LFHYSRAWKS THPVNSEFAP VHPLMRLAAK LPSRRMKRLP RLLHTDSRMA
TIDFPKKDPT TSLGRPFFLF RPRNGRYTDK VQ
