ID   NMT_MIMIV               Reviewed;         358 AA.
AC   Q5UR64;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Putative glycylpeptide N-tetradecanoyltransferase;
DE            EC=2.3.1.97;
DE   AltName: Full=Myristoyl-CoA:protein N-myristoyltransferase;
DE            Short=NMT;
DE   AltName: Full=Peptide N-myristoyltransferase;
GN   OrderedLocusNames=MIMI_L621;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
CC   -!- FUNCTION: Adds a myristoyl group to the N-terminal glycine residue of
CC       certain proteins. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) +
CC         N-tetradecanoylglycyl-[protein]; Xref=Rhea:RHEA:15521, Rhea:RHEA-
CC         COMP:12666, Rhea:RHEA-COMP:12667, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:64723,
CC         ChEBI:CHEBI:133050; EC=2.3.1.97;
CC   -!- SIMILARITY: Belongs to the NMT family. {ECO:0000305}.
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DR   EMBL; AY653733; AAV50882.1; -; Genomic_DNA.
DR   RefSeq; YP_003987138.1; NC_014649.1.
DR   SMR; Q5UR64; -.
DR   PRIDE; Q5UR64; -.
DR   GeneID; 9925262; -.
DR   KEGG; vg:9925262; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0004379; F:glycylpeptide N-tetradecanoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006499; P:N-terminal protein myristoylation; IEA:InterPro.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000903; NMT.
DR   InterPro; IPR022677; NMT_C.
DR   InterPro; IPR022676; NMT_N.
DR   PANTHER; PTHR11377; PTHR11377; 1.
DR   Pfam; PF01233; NMT; 1.
DR   Pfam; PF02799; NMT_C; 1.
DR   SUPFAM; SSF55729; SSF55729; 2.
PE   3: Inferred from homology;
KW   Acyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..358
FT                   /note="Putative glycylpeptide N-tetradecanoyltransferase"
FT                   /id="PRO_0000064251"
SQ   SEQUENCE   358 AA;  41997 MW;  F6D9DC09399B6C81 CRC64;
     MSNLNLFETN QNKSISIMTQ DITKLLDPLT EKFDGFSIKT LNVKHVDEIH ELLNKHYIED
     NDHIIRIIYS RDFLYWYLKY VPNNFTIGLM YKNKLVGLIT ALFVDMIMYD NKIKIPYINF
     FCIQNKIRKF GLSNILIEEL KSRLLKIGVA YSLFTRMNCQ NSLDKHFTST IDFAIPINCP
     KLKSVGFIPD DEKLMNWKIE NNPLSLMVKT DILSVTSKLN VHLQHLSVRP YLTEDSVHHF
     ILPKKNIVYT FVKRDSRGYV TDMVSVYKHY AYILETGKII SNAQLSFYYN ETMDLTQLIL
     LLLDKLINYG FDQLIFRNFY DNGKINITRF ETNGELNYYA GNISMPITCP NNMFMIPI