NMUR1_HUMAN
ID NMUR1_HUMAN Reviewed; 426 AA.
AC Q9HB89; O43664; Q7LDP6; Q8NE20;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Neuromedin-U receptor 1;
DE Short=NMU-R1;
DE AltName: Full=G-protein coupled receptor 66;
DE AltName: Full=G-protein coupled receptor FM-3;
GN Name=NMUR1; Synonyms=GPR66;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=10899166; DOI=10.1074/jbc.m004613200;
RA Raddatz R., Wilson A.E., Artymyshyn R., Bonini J.A., Borowsky B.,
RA Boteju L.W., Zhou S., Kouranova E.V., Nagorny R., Guevarra M.S., Dai M.,
RA Lerman G.S., Vaysse P.J., Branchek T.A., Gerald C., Forray C., Adham N.;
RT "Identification and characterization of two neuromedin U receptors
RT differentially expressed in peripheral tissues and the central nervous
RT system.";
RL J. Biol. Chem. 275:32452-32459(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PNS, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-426, AND TISSUE SPECIFICITY.
RX PubMed=9782091; DOI=10.1006/geno.1998.5441;
RA Tan C.P., McKee K.K., Liu Q., Palyha O.C., Feighner S.D., Hreniuk D.L.,
RA Smith R.G., Howard A.D.;
RT "Cloning and characterization of a human and murine T-cell orphan G-
RT protein-coupled receptor similar to the growth hormone secretagogue and
RT neurotensin receptors.";
RL Genomics 52:223-229(1998).
CC -!- FUNCTION: Receptor for the neuromedin-U and neuromedin-S neuropeptides.
CC {ECO:0000250, ECO:0000269|PubMed:10899166}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in greatest abundance in peripheral
CC organs, particularly in elements of the gastrointestinal and urogenital
CC systems with highest levels in testes. In central nervous system
CC structures express levels are much lower than those seen in peripheral
CC organs. Within the CNS, has been detected in highest abundance in the
CC cerebellum, dorsal root ganglia, hippocampus, and spinal cord.
CC {ECO:0000269|PubMed:10899166, ECO:0000269|PubMed:9782091}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-24 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AF272362; AAG24793.1; -; mRNA.
DR EMBL; AC017104; AAY24249.1; -; Genomic_DNA.
DR EMBL; BC036543; AAH36543.1; -; mRNA.
DR EMBL; BC051914; AAH51914.1; -; mRNA.
DR EMBL; AF044601; AAC02680.1; -; Genomic_DNA.
DR EMBL; AF044600; AAC02680.1; JOINED; Genomic_DNA.
DR CCDS; CCDS2486.1; -.
DR RefSeq; NP_006047.3; NM_006056.4.
DR RefSeq; XP_011508789.1; XM_011510487.2.
DR AlphaFoldDB; Q9HB89; -.
DR SMR; Q9HB89; -.
DR BioGRID; 115600; 407.
DR STRING; 9606.ENSP00000305877; -.
DR BindingDB; Q9HB89; -.
DR ChEMBL; CHEMBL1075178; -.
DR GuidetoPHARMACOLOGY; 298; -.
DR TCDB; 9.A.14.1.13; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; Q9HB89; 3 sites.
DR iPTMnet; Q9HB89; -.
DR PhosphoSitePlus; Q9HB89; -.
DR BioMuta; NMUR1; -.
DR DMDM; 74761608; -.
DR PaxDb; Q9HB89; -.
DR PRIDE; Q9HB89; -.
DR Antibodypedia; 20210; 226 antibodies from 29 providers.
DR DNASU; 10316; -.
DR Ensembl; ENST00000305141.5; ENSP00000305877.4; ENSG00000171596.7.
DR GeneID; 10316; -.
DR KEGG; hsa:10316; -.
DR MANE-Select; ENST00000305141.5; ENSP00000305877.4; NM_006056.5; NP_006047.3.
DR UCSC; uc002vry.5; human.
DR CTD; 10316; -.
DR DisGeNET; 10316; -.
DR GeneCards; NMUR1; -.
DR HGNC; HGNC:4518; NMUR1.
DR HPA; ENSG00000171596; Tissue enhanced (retina).
DR MIM; 604153; gene.
DR neXtProt; NX_Q9HB89; -.
DR OpenTargets; ENSG00000171596; -.
DR PharmGKB; PA28910; -.
DR VEuPathDB; HostDB:ENSG00000171596; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244813; -.
DR HOGENOM; CLU_009579_6_5_1; -.
DR InParanoid; Q9HB89; -.
DR OMA; QYVHIIS; -.
DR OrthoDB; 890529at2759; -.
DR PhylomeDB; Q9HB89; -.
DR TreeFam; TF318522; -.
DR PathwayCommons; Q9HB89; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q9HB89; -.
DR SIGNOR; Q9HB89; -.
DR BioGRID-ORCS; 10316; 12 hits in 1067 CRISPR screens.
DR ChiTaRS; NMUR1; human.
DR GeneWiki; Neuromedin_U_receptor_1; -.
DR GenomeRNAi; 10316; -.
DR Pharos; Q9HB89; Tchem.
DR PRO; PR:Q9HB89; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9HB89; protein.
DR Bgee; ENSG00000171596; Expressed in granulocyte and 86 other tissues.
DR Genevisible; Q9HB89; HS.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042924; F:neuromedin U binding; IDA:UniProtKB.
DR GO; GO:0001607; F:neuromedin U receptor activity; IDA:UniProtKB.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0007202; P:activation of phospholipase C activity; IDA:UniProtKB.
DR GO; GO:0006816; P:calcium ion transport; IDA:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; IDA:UniProtKB.
DR GO; GO:0006821; P:chloride transport; IDA:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0048016; P:inositol phosphate-mediated signaling; IDA:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0006939; P:smooth muscle contraction; IEP:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR005390; NeuromedU_rcpt.
DR InterPro; IPR005391; NeuromedU_rcpt_1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01565; NEUROMEDINUR.
DR PRINTS; PR01566; NEUROMEDNU1R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..426
FT /note="Neuromedin-U receptor 1"
FT /id="PRO_0000069906"
FT TOPO_DOM 1..65
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..138
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..161
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..235
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..338
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 134..219
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 203
FT /note="R -> Q (in Ref. 3; AAH36543)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 47351 MW; F8DD781C020F04AA CRC64;
MTPLCLNCSV LPGDLYPGGA RNPMACNGSA ARGHFDPEDL NLTDEALRLK YLGPQQTELF
MPICATYLLI FVVGAVGNGL TCLVILRHKA MRTPTNYYLF SLAVSDLLVL LVGLPLELYE
MWHNYPFLLG VGGCYFRTLL FEMVCLASVL NVTALSVERY VAVVHPLQAR SMVTRAHVRR
VLGAVWGLAM LCSLPNTSLH GIRQLHVPCR GPVPDSAVCM LVRPRALYNM VVQTTALLFF
CLPMAIMSVL YLLIGLRLRR ERLLLMQEAK GRGSAAARSR YTCRLQQHDR GRRQVTKMLF
VLVVVFGICW APFHADRVMW SVVSQWTDGL HLAFQHVHVI SGIFFYLGSA ANPVLYSLMS
SRFRETFQEA LCLGACCHRL RPRHSSHSLS RMTTGSTLCD VGSLGSWVHP LAGNDGPEAQ
QETDPS
