NMUR1_MOUSE
ID NMUR1_MOUSE Reviewed; 428 AA.
AC O55040; G5E871; Q0VB23;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-MAR-2016, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Neuromedin-U receptor 1;
DE Short=NMU-R1;
DE AltName: Full=G-protein coupled receptor 66;
DE AltName: Full=G-protein coupled receptor FM-3;
GN Name=Nmur1; Synonyms=Gpr66;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-428.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-428, AND TISSUE SPECIFICITY.
RX PubMed=9782091; DOI=10.1006/geno.1998.5441;
RA Tan C.P., McKee K.K., Liu Q., Palyha O.C., Feighner S.D., Hreniuk D.L.,
RA Smith R.G., Howard A.D.;
RT "Cloning and characterization of a human and murine T-cell orphan G-
RT protein-coupled receptor similar to the growth hormone secretagogue and
RT neurotensin receptors.";
RL Genomics 52:223-229(1998).
CC -!- FUNCTION: Receptor for the neuromedin-U and neuromedin-S neuropeptides.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:9782091}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI20823.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI37776.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EDL40217.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC102609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466520; EDL40217.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC120822; AAI20823.1; ALT_INIT; mRNA.
DR EMBL; BC137775; AAI37776.1; ALT_INIT; mRNA.
DR EMBL; AF044602; AAC02681.1; -; mRNA.
DR CCDS; CCDS15119.2; -.
DR RefSeq; NP_001306156.1; NM_001319227.1.
DR RefSeq; NP_034471.1; NM_010341.1.
DR AlphaFoldDB; O55040; -.
DR SMR; O55040; -.
DR STRING; 10090.ENSMUSP00000027440; -.
DR BindingDB; O55040; -.
DR ChEMBL; CHEMBL3351216; -.
DR GlyGen; O55040; 2 sites.
DR iPTMnet; O55040; -.
DR PhosphoSitePlus; O55040; -.
DR PaxDb; O55040; -.
DR PRIDE; O55040; -.
DR Antibodypedia; 20210; 226 antibodies from 29 providers.
DR DNASU; 14767; -.
DR Ensembl; ENSMUST00000212058; ENSMUSP00000148767; ENSMUSG00000026237.
DR GeneID; 14767; -.
DR KEGG; mmu:14767; -.
DR UCSC; uc007bvn.2; mouse.
DR CTD; 10316; -.
DR MGI; MGI:1341898; Nmur1.
DR VEuPathDB; HostDB:ENSMUSG00000026237; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244813; -.
DR InParanoid; O55040; -.
DR OMA; QYVHIIS; -.
DR OrthoDB; 890529at2759; -.
DR TreeFam; TF318522; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 14767; 0 hits in 72 CRISPR screens.
DR PRO; PR:O55040; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; O55040; protein.
DR Bgee; ENSMUSG00000026237; Expressed in heart right ventricle and 19 other tissues.
DR ExpressionAtlas; O55040; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042924; F:neuromedin U binding; ISO:MGI.
DR GO; GO:0001607; F:neuromedin U receptor activity; ISO:MGI.
DR GO; GO:0008188; F:neuropeptide receptor activity; IPI:MGI.
DR GO; GO:0007202; P:activation of phospholipase C activity; ISO:MGI.
DR GO; GO:0006816; P:calcium ion transport; ISO:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; ISO:MGI.
DR GO; GO:0006821; P:chloride transport; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0048016; P:inositol phosphate-mediated signaling; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR005390; NeuromedU_rcpt.
DR InterPro; IPR005391; NeuromedU_rcpt_1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01565; NEUROMEDINUR.
DR PRINTS; PR01566; NEUROMEDNU1R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..428
FT /note="Neuromedin-U receptor 1"
FT /id="PRO_0000069907"
FT TOPO_DOM 1..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..137
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..235
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..339
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 134..219
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 428 AA; 47934 MW; BB5BD67BCAA1E264 CRC64;
MTPPCLNCSI FPGALSPNAS RSPLVCNISE FKWPYQPEDL NLTDEALRLK YLGPQQMKQF
VPICVTYLLI FVVGTLGNGL TCTVILRNKT MRTPTNFYLF SLAVSDMLVL LVGLPLELYE
MQQNYPFQLG ASACYFRILL LETVCLASVL NVTALSVERY VAVVRPLQAK SVMTRAHVRR
MVGAIWVLAT LFSLPNTSLH GLSQLTVPCR GPVPDSAICS LVGPMDFYKL VVLTTALLFF
CLPMVTISVL YLLIGLRLRR ERMLLQVEVK GRKTAATQET SHRRIQLQDR GRRQVTKMLF
ALVVVFGICW APFHADRIMW SLVYGHSTEG LHLAYQCVHI ASGIFFYLGS AANPVLYSLM
STRFRETFLQ ALGLGTQCCH RRQPYHGSHN HIRLTTGSTL CDVGHRNSRD EPLAVNEDPG
CQQETDPS
