NMUR1_RAT
ID NMUR1_RAT Reviewed; 425 AA.
AC Q9JJI5; F1LQC9; Q9JIB2;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-MAR-2016, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Neuromedin-U receptor 1;
DE Short=NMU-R1;
DE AltName: Full=G-protein coupled receptor 66;
DE AltName: Full=G-protein coupled receptor FM-3;
GN Name=Nmur1; Synonyms=Gpr66;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 14-425, FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=10783389; DOI=10.1074/jbc.m001546200;
RA Fujii R., Hosoya M., Fukusumi S., Kawamata Y., Habata Y., Hinuma S.,
RA Onda H., Nishimura O., Fujino M.;
RT "Identification of neuromedin U as the cognate ligand of the orphan G
RT protein-coupled receptor FM-3.";
RL J. Biol. Chem. 275:21068-21074(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-425.
RC STRAIN=Sprague-Dawley;
RX PubMed=10894543; DOI=10.1038/35017610;
RA Howard A.D., Wang R., Pong S.-S., Mellin T.N., Strack A., Guan X.-M.,
RA Zeng Z., Williams D.L., Feighner S.D., Nunes C.N., Murphy B., Stair J.N.,
RA Yu H., Jiang Q., Clements M.K., Tan C.P., Mckee K.K., Hreniuk D.L.,
RA Mcdonald T.P., Lynch K.R., Evans J.F., Austin C.P., Caskey T.,
RA van der Ploeg L.H.T., Liu Q.;
RT "Identification of receptors for neuromedin U and its role in feeding.";
RL Nature 406:70-74(2000).
RN [4]
RP FUNCTION AS A NEUROMEDIN-S RECEPTOR.
RX PubMed=15635449; DOI=10.1038/sj.emboj.7600526;
RA Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M.,
RA Kangawa K.;
RT "Identification of neuromedin S and its possible role in the mammalian
RT circadian oscillator system.";
RL EMBO J. 24:325-335(2005).
CC -!- FUNCTION: Receptor for the neuromedin-U and neuromedin-S neuropeptides.
CC {ECO:0000269|PubMed:10783389, ECO:0000269|PubMed:15635449}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in the small intestine and lung.
CC Low expression in the central nervous system.
CC {ECO:0000269|PubMed:10783389}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AC112440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB038649; BAA99387.1; -; mRNA.
DR EMBL; AF242873; AAF82754.1; -; mRNA.
DR AlphaFoldDB; Q9JJI5; -.
DR SMR; Q9JJI5; -.
DR STRING; 10116.ENSRNOP00000025024; -.
DR GlyGen; Q9JJI5; 1 site.
DR PhosphoSitePlus; Q9JJI5; -.
DR PaxDb; Q9JJI5; -.
DR UCSC; RGD:619867; rat.
DR RGD; 619867; Nmur1.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q9JJI5; -.
DR TreeFam; TF318522; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:Q9JJI5; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042924; F:neuromedin U binding; ISO:RGD.
DR GO; GO:0001607; F:neuromedin U receptor activity; ISO:RGD.
DR GO; GO:0008188; F:neuropeptide receptor activity; ISO:RGD.
DR GO; GO:0007202; P:activation of phospholipase C activity; ISO:RGD.
DR GO; GO:0006816; P:calcium ion transport; ISO:RGD.
DR GO; GO:0019722; P:calcium-mediated signaling; ISO:RGD.
DR GO; GO:0006821; P:chloride transport; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0048016; P:inositol phosphate-mediated signaling; ISO:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISO:RGD.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0006939; P:smooth muscle contraction; ISO:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR005390; NeuromedU_rcpt.
DR InterPro; IPR005391; NeuromedU_rcpt_1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01565; NEUROMEDINUR.
DR PRINTS; PR01566; NEUROMEDNU1R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..425
FT /note="Neuromedin-U receptor 1"
FT /id="PRO_0000069908"
FT TOPO_DOM 1..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..137
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..235
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..331
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..425
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 406..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 134..219
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 14
FT /note="Q -> M (in Ref. 2; BAA99387)"
FT /evidence="ECO:0000305"
FT CONFLICT 263
FT /note="I -> M (in Ref. 2; BAA99387)"
FT /evidence="ECO:0000305"
FT CONFLICT 354
FT /note="V -> E (in Ref. 2; BAA99387)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 48129 MW; 16DD0173D5DBB23E CRC64;
MTPPCLNCSF FPGQLSPNAS TGLLSCNDSE FKEHFDLEDL NLTHEDLRLK YLGPQQVKQF
LPICVTYLLI FVVGTLGNGL TCTVILRQKA MHTPTNFYLF SLAVSDLLVL LVGLPLELYE
MQHNYPFQLG AGGCYFRILL LETVCLASVL NVTALSVERY VAVVHPLQAK SVMTRTHVRR
MLGAIWVFAI LFSLPNTSLH GLSPLYVPCR GPVPDSVTCT LVRPQFFYKL VIQTTILLFF
CLPMVTISVL YLLIGLRLRR ERILLQEEVK GRISAAARQA SHRSIQLRDR ERRQVTKMLI
ALVIVFGTCW VPFHADRLMW SMVSHWTDGL RLAFQSVHLA SGVFLYLGSA ANPVLYNLMS
TRFRESFRET LGLGTRCCHR HQPRHDSHSH LRLTTVSTLC DRNSRDVPLA ENRDPGCEQE
TDPPE
