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NMUR2_BOVIN
ID   NMUR2_BOVIN             Reviewed;         407 AA.
AC   Q58CW4;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Neuromedin-U receptor 2;
DE            Short=NMU-R2;
GN   Name=NMUR2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Receptor for the neuromedin-U and neuromedin-S neuropeptides.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; BT021833; AAX46680.1; -; mRNA.
DR   RefSeq; NP_001030220.1; NM_001035048.1.
DR   AlphaFoldDB; Q58CW4; -.
DR   SMR; Q58CW4; -.
DR   STRING; 9913.ENSBTAP00000014782; -.
DR   PaxDb; Q58CW4; -.
DR   PRIDE; Q58CW4; -.
DR   GeneID; 507439; -.
DR   KEGG; bta:507439; -.
DR   CTD; 56923; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   HOGENOM; CLU_009579_6_5_1; -.
DR   InParanoid; Q58CW4; -.
DR   OrthoDB; 890529at2759; -.
DR   TreeFam; TF318522; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0001607; F:neuromedin U receptor activity; IEA:InterPro.
DR   GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR005390; NeuromedU_rcpt.
DR   InterPro; IPR005392; NeuromedU_rcpt_2.
DR   InterPro; IPR045561; NMU-R2_C.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF19285; NmU-R2_C_term; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01565; NEUROMEDINUR.
DR   PRINTS; PR01567; NEUROMEDNU2R.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..407
FT                   /note="Neuromedin-U receptor 2"
FT                   /id="PRO_0000069909"
FT   TOPO_DOM        1..47
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..79
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..120
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..139
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..162
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..211
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..262
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..298
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        320..407
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        24
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        191
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        116..201
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   407 AA;  46343 MW;  6C49046C250DBC22 CRC64;
     MEKHENVSWM YQQELKDPFK KYLNNTDDYL ALLCGPRRSH LFLPVTAVYA LIFVVGVVGN
     LLVCLVILRH QTMKTPTNYY LFSLAVSDLL VLLLGMPLEV YEMWRNYPFL FGPVGCYFKT
     ALFETVCFAS ILSVTTVSVE RYVAVLHPFR AKLKSTRGRA LRILGIVWGL SVLFSLPNTS
     IHGIKLHYFP NGSIIPGSAT CTVIKPMWIY NFIIQVTSLL FYILPMTVIS VLYYLMGLKL
     KKDQHLEADK VTANIQRPSR KSVTKMLFVL VLVFAICWAP FHIDRLFFSF VEEWTEPLAA
     VFNLIHVVSG VFFYLSSAVN PIIYNLLSHR FQAAFRTVIP PSCQQQHSHN HSPGPSMQRN
     IFLTECHLVE LTEDVAPQFP RQLSVLSSQL PTALCTGQVP RKELAKS
 
 
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