NMUR2_MOUSE
ID NMUR2_MOUSE Reviewed; 395 AA.
AC Q8BZ39; Q91Z76;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Neuromedin-U receptor 2;
DE Short=NMU-R2;
GN Name=Nmur2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=12217421; DOI=10.1016/s0196-9781(02)00097-9;
RA Funes S., Hedrick J.A., Yang S., Shan L., Bayne M., Monsma F.J. Jr.,
RA Gustafson E.L.;
RT "Cloning and characterization of murine neuromedin U receptors.";
RL Peptides 23:1607-1615(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Receptor for the neuromedin-U and neuromedin-S neuropeptides.
CC {ECO:0000250, ECO:0000269|PubMed:12217421}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed primarily in brain tissues, more
CC specifically in medulla and spinal cord. Widespread distribution in
CC peripheral tissues. {ECO:0000269|PubMed:12217421}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY057384; AAL26695.1; -; mRNA.
DR EMBL; AK036756; BAC29564.1; -; mRNA.
DR EMBL; AL671969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS24716.1; -.
DR RefSeq; NP_694719.2; NM_153079.4.
DR AlphaFoldDB; Q8BZ39; -.
DR SMR; Q8BZ39; -.
DR STRING; 10090.ENSMUSP00000044718; -.
DR BindingDB; Q8BZ39; -.
DR ChEMBL; CHEMBL3351217; -.
DR GlyGen; Q8BZ39; 3 sites.
DR PhosphoSitePlus; Q8BZ39; -.
DR PaxDb; Q8BZ39; -.
DR PRIDE; Q8BZ39; -.
DR ProteomicsDB; 252974; -.
DR Antibodypedia; 16394; 195 antibodies from 29 providers.
DR DNASU; 216749; -.
DR Ensembl; ENSMUST00000037682; ENSMUSP00000044718; ENSMUSG00000037393.
DR GeneID; 216749; -.
DR KEGG; mmu:216749; -.
DR UCSC; uc007izq.1; mouse.
DR CTD; 56923; -.
DR MGI; MGI:2441765; Nmur2.
DR VEuPathDB; HostDB:ENSMUSG00000037393; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244813; -.
DR HOGENOM; CLU_009579_6_5_1; -.
DR InParanoid; Q8BZ39; -.
DR OMA; YTVMTYV; -.
DR OrthoDB; 890529at2759; -.
DR PhylomeDB; Q8BZ39; -.
DR TreeFam; TF318522; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 216749; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q8BZ39; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BZ39; protein.
DR Bgee; ENSMUSG00000037393; Expressed in submandibular gland and 6 other tissues.
DR Genevisible; Q8BZ39; MM.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; ISO:MGI.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; ISO:MGI.
DR GO; GO:0042924; F:neuromedin U binding; ISO:MGI.
DR GO; GO:0001607; F:neuromedin U receptor activity; ISO:MGI.
DR GO; GO:0008188; F:neuropeptide receptor activity; IPI:MGI.
DR GO; GO:0050482; P:arachidonic acid secretion; ISO:MGI.
DR GO; GO:0006816; P:calcium ion transport; ISO:MGI.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007625; P:grooming behavior; IMP:MGI.
DR GO; GO:0048016; P:inositol phosphate-mediated signaling; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0002023; P:reduction of food intake in response to dietary excess; IMP:MGI.
DR GO; GO:0051930; P:regulation of sensory perception of pain; ISO:MGI.
DR GO; GO:0048265; P:response to pain; IMP:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR005390; NeuromedU_rcpt.
DR InterPro; IPR005392; NeuromedU_rcpt_2.
DR InterPro; IPR045561; NMU-R2_C.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF19285; NmU-R2_C_term; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01565; NEUROMEDINUR.
DR PRINTS; PR01567; NEUROMEDNU2R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..395
FT /note="Neuromedin-U receptor 2"
FT /id="PRO_0000069911"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..293
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..395
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 111..196
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 202
FT /note="I -> M (in Ref. 1; AAL26695)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 395 AA; 44827 MW; 0EA292C1947142FD CRC64;
MGKLENASWI HDSLMKYLNS TEEYLAYLCG PKRSDLSLPV SVVYALIFVV GVIGNLLVCL
VIARHQTLKT PTNYYLFSLA VSDLLVLLLG MPLEVYELWH NYPFLFGPVG CYFKTALFET
VCFASILSVT TVSIERYVAI VHPFRAKLES TRRRALRILS LVWSFSVVFS LPNTSIHGIK
FQQFPNGSSV PGSATCTVTK PIWVYNFIIQ ATSFLFYILP MTLISVLYYL MGLRLKRDES
LEADKVTVNI HRPSRKSVTK MLFVLVLVFA ICWTPFHVDR LFFSFVDEWT ESLAAVFNLI
HVVSGVFFYL SSAVNPIIYN LLSRRFRAAF RNVVSPSCKW CHPQHRPQGP PAQKVIFLTE
CHLVELTEDA GPQFPCQSSI HNTQLTTVPC VEEVP
