ID   NMU_CANLF               Reviewed;          25 AA.
AC   P34962;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Neuromedin-U-25;
DE            Short=NmU-25;
DE   Contains:
DE     RecName: Full=Neuromedin-U-8;
DE              Short=NmU-8;
GN   Name=NMU;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-18, AND AMIDATION AT
RP   ASN-25.
RC   TISSUE=Small intestine;
RX   PubMed=2052487; DOI=10.1016/0196-9781(91)90159-m;
RA   O'Harte F., Bockman C.S., Abel P.W., Conlon J.M.;
RT   "Isolation, structural characterization and pharmacological activity of dog
RT   neuromedin U.";
RL   Peptides 12:11-15(1991).
CC   -!- FUNCTION: Stimulates uterine smooth muscle contraction and causes
CC       selective vasoconstriction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
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DR   AlphaFoldDB; P34962; -.
DR   STRING; 9612.ENSCAFP00000039888; -.
DR   PaxDb; P34962; -.
DR   HOGENOM; CLU_221025_0_0_1; -.
DR   InParanoid; P34962; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006940; P:regulation of smooth muscle contraction; IEA:InterPro.
DR   InterPro; IPR018070; Neuromedin-U_amidation-site.
DR   InterPro; IPR008200; NMU_C.
DR   Pfam; PF02070; NMU; 1.
DR   SMART; SM00084; NMU; 1.
DR   PROSITE; PS00967; NMU; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Pyrrolidone carboxylic acid; Reference proteome; Secreted.
FT   PEPTIDE         1..25
FT                   /note="Neuromedin-U-25"
FT                   /id="PRO_0000019770"
FT   PEPTIDE         18..25
FT                   /note="Neuromedin-U-8"
FT                   /id="PRO_0000019771"
FT   MOD_RES         18
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2052487"
FT   MOD_RES         25
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:2052487"
SQ   SEQUENCE   25 AA;  3108 MW;  35297BB920E3087C CRC64;
     FRLDEEFQGP IASQVRRQFL FRPRN