ID   NMU_CHICK               Reviewed;          25 AA.
AC   P34963;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Neuromedin-U-25;
DE            Short=NmU-25;
DE   Contains:
DE     RecName: Full=Neuromedin-U-9;
DE              Short=NmU-9;
GN   Name=NMU;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=1455013; DOI=10.1016/0167-0115(92)90508-r;
RA   Domin J., Benito-Orfila M.A., Nandha K.A., Aitken A., Bloom S.R.;
RT   "The purification and sequence analysis of an avian neuromedin U.";
RL   Regul. Pept. 41:1-8(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 17-25, AND AMIDATION AT ASN-25.
RC   TISSUE=Intestine;
RX   PubMed=1788145; DOI=10.1016/0196-9781(91)90138-f;
RA   O'Harte F., Bockman C.S., Zeng W., Abel P.W., Harvey S., Conlon J.M.;
RT   "Primary structure and pharmacological activity of a nonapeptide related to
RT   neuromedin U isolated from chicken intestine.";
RL   Peptides 12:809-812(1991).
CC   -!- FUNCTION: Stimulates uterine smooth muscle contraction and causes
CC       selective vasoconstriction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A48543; A48543.
DR   AlphaFoldDB; P34963; -.
DR   STRING; 9031.ENSGALP00000031462; -.
DR   PaxDb; P34963; -.
DR   eggNOG; ENOG502S36R; Eukaryota.
DR   HOGENOM; CLU_090356_0_0_1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006940; P:regulation of smooth muscle contraction; IEA:InterPro.
DR   InterPro; IPR018070; Neuromedin-U_amidation-site.
DR   InterPro; IPR008200; NMU_C.
DR   Pfam; PF02070; NMU; 1.
DR   SMART; SM00084; NMU; 1.
DR   PROSITE; PS00967; NMU; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Reference proteome;
KW   Secreted.
FT   PEPTIDE         1..25
FT                   /note="Neuromedin-U-25"
FT                   /id="PRO_0000019783"
FT   PEPTIDE         17..25
FT                   /note="Neuromedin-U-9"
FT                   /id="PRO_0000019784"
FT   MOD_RES         25
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:1788145"
SQ   SEQUENCE   25 AA;  2921 MW;  54209D8487686B1A CRC64;
     YKVDEDLQGA GGIQSRGYFF FRPRN