NMU_HUMAN
ID NMU_HUMAN Reviewed; 174 AA.
AC P48645;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Neuromedin-U;
DE Contains:
DE RecName: Full=Neuromedin precursor-related peptide 36 {ECO:0000250|UniProtKB:P12760};
DE Short=NURP36 {ECO:0000250|UniProtKB:P12760};
DE Contains:
DE RecName: Full=Neuromedin precursor-related peptide 33 {ECO:0000250|UniProtKB:P12760};
DE Short=NURP33 {ECO:0000250|UniProtKB:P12760};
DE Contains:
DE RecName: Full=Neuromedin-U-25;
DE Short=NmU-25;
DE Flags: Precursor;
GN Name=NMU;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RX PubMed=7619205; DOI=10.1677/jme.0.0140157;
RA Austin C., Lo G., Nandha K.A., Meleagros L., Bloom S.R.;
RT "Cloning and characterization of the cDNA encoding the human neuromedin U
RT (NmU) precursor: NmU expression in the human gastrointestinal tract.";
RL J. Mol. Endocrinol. 14:157-169(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: [Neuromedin-U-25]: Ligand for receptors NMUR1 and NMUR2 (By
CC similarity). Stimulates muscle contractions of specific regions of the
CC gastrointestinal tract. In humans, NmU stimulates contractions of the
CC ileum and urinary bladder. {ECO:0000250|UniProtKB:P12760}.
CC -!- FUNCTION: [Neuromedin precursor-related peptide 33]: Does not function
CC as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin
CC release although its potency is much lower than that of neuromedin
CC precursor-related peptide 36. {ECO:0000250|UniProtKB:P12760}.
CC -!- FUNCTION: [Neuromedin precursor-related peptide 36]: Does not function
CC as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin
CC release from lactotroph cells in the pituitary gland, probably via the
CC hypothalamic dopaminergic system. {ECO:0000250|UniProtKB:P12760}.
CC -!- INTERACTION:
CC P48645; Q86V38: ATN1; NbExp=3; IntAct=EBI-10210351, EBI-11954292;
CC P48645; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10210351, EBI-3867333;
CC P48645; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-10210351, EBI-10303987;
CC P48645; Q92876: KLK6; NbExp=3; IntAct=EBI-10210351, EBI-2432309;
CC P48645; O76011: KRT34; NbExp=3; IntAct=EBI-10210351, EBI-1047093;
CC P48645; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10210351, EBI-11959885;
CC P48645; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10210351, EBI-11749135;
CC P48645; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-10210351, EBI-11741292;
CC P48645; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10210351, EBI-12012928;
CC P48645; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10210351, EBI-11953334;
CC P48645; Q9BYP8: KRTAP17-1; NbExp=5; IntAct=EBI-10210351, EBI-11988175;
CC P48645; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-10210351, EBI-3958099;
CC P48645; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10210351, EBI-945833;
CC P48645; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10210351, EBI-22310682;
CC P48645; P23219: PTGS1; NbExp=3; IntAct=EBI-10210351, EBI-6655935;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed throughout the enteric nervous system
CC with highest levels being found in the jejunum.
CC -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
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DR EMBL; X76029; CAA53619.1; -; mRNA.
DR EMBL; BC012908; AAH12908.1; -; mRNA.
DR CCDS; CCDS3501.1; -.
DR PIR; I38063; I38063.
DR RefSeq; NP_001278974.1; NM_001292045.1.
DR RefSeq; NP_001278975.1; NM_001292046.1.
DR RefSeq; NP_006672.1; NM_006681.3.
DR AlphaFoldDB; P48645; -.
DR BioGRID; 116082; 121.
DR IntAct; P48645; 27.
DR STRING; 9606.ENSP00000264218; -.
DR iPTMnet; P48645; -.
DR PhosphoSitePlus; P48645; -.
DR BioMuta; NMU; -.
DR DMDM; 1346685; -.
DR EPD; P48645; -.
DR jPOST; P48645; -.
DR MassIVE; P48645; -.
DR MaxQB; P48645; -.
DR PaxDb; P48645; -.
DR PeptideAtlas; P48645; -.
DR PRIDE; P48645; -.
DR ProteomicsDB; 55919; -.
DR Antibodypedia; 12370; 177 antibodies from 27 providers.
DR DNASU; 10874; -.
DR Ensembl; ENST00000264218.7; ENSP00000264218.3; ENSG00000109255.11.
DR GeneID; 10874; -.
DR KEGG; hsa:10874; -.
DR MANE-Select; ENST00000264218.7; ENSP00000264218.3; NM_006681.4; NP_006672.1.
DR UCSC; uc003hbc.3; human.
DR CTD; 10874; -.
DR DisGeNET; 10874; -.
DR GeneCards; NMU; -.
DR HGNC; HGNC:7859; NMU.
DR HPA; ENSG00000109255; Tissue enhanced (esophagus, skin, vagina).
DR MIM; 605103; gene.
DR neXtProt; NX_P48645; -.
DR OpenTargets; ENSG00000109255; -.
DR PharmGKB; PA31663; -.
DR VEuPathDB; HostDB:ENSG00000109255; -.
DR eggNOG; ENOG502S36R; Eukaryota.
DR GeneTree; ENSGT00510000048726; -.
DR HOGENOM; CLU_090356_0_0_1; -.
DR InParanoid; P48645; -.
DR OMA; CFMVMGI; -.
DR OrthoDB; 1515830at2759; -.
DR PhylomeDB; P48645; -.
DR TreeFam; TF338319; -.
DR PathwayCommons; P48645; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; P48645; -.
DR BioGRID-ORCS; 10874; 9 hits in 1077 CRISPR screens.
DR ChiTaRS; NMU; human.
DR GenomeRNAi; 10874; -.
DR Pharos; P48645; Tbio.
DR PRO; PR:P48645; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; P48645; protein.
DR Bgee; ENSG00000109255; Expressed in tongue squamous epithelium and 139 other tissues.
DR ExpressionAtlas; P48645; baseline and differential.
DR Genevisible; P48645; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0043195; C:terminal bouton; IBA:GO_Central.
DR GO; GO:0042922; F:neuromedin U receptor binding; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR GO; GO:0031839; F:type 1 neuromedin U receptor binding; IDA:UniProtKB.
DR GO; GO:0031840; F:type 2 neuromedin U receptor binding; IDA:UniProtKB.
DR GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:UniProtKB.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; IBA:GO_Central.
DR GO; GO:0050806; P:positive regulation of synaptic transmission; IBA:GO_Central.
DR GO; GO:0060259; P:regulation of feeding behavior; IEA:Ensembl.
DR GO; GO:2000821; P:regulation of grooming behavior; IEA:Ensembl.
DR GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
DR InterPro; IPR018070; Neuromedin-U_amidation-site.
DR InterPro; IPR042384; NMU.
DR InterPro; IPR008200; NMU_C.
DR PANTHER; PTHR15390; PTHR15390; 1.
DR Pfam; PF02070; NMU; 1.
DR SMART; SM00084; NMU; 1.
DR PROSITE; PS00967; NMU; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide; Oxidation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT PROPEP 35..103
FT /id="PRO_0000019772"
FT PEPTIDE 104..139
FT /note="Neuromedin precursor-related peptide 36"
FT /evidence="ECO:0000250|UniProtKB:P12760"
FT /id="PRO_0000445765"
FT PEPTIDE 104..136
FT /note="Neuromedin precursor-related peptide 33"
FT /evidence="ECO:0000250|UniProtKB:P12760"
FT /id="PRO_0000445766"
FT PEPTIDE 142..166
FT /note="Neuromedin-U-25"
FT /id="PRO_0000019773"
FT PROPEP 170..174
FT /id="PRO_0000019774"
FT MOD_RES 139
FT /note="Methionine sulfoxide; partial"
FT /evidence="ECO:0000250|UniProtKB:P12760"
FT MOD_RES 166
FT /note="Asparagine amide"
FT /evidence="ECO:0000250"
FT VARIANT 79
FT /note="E -> G (in dbSNP:rs35892915)"
FT /id="VAR_053538"
FT VARIANT 148
FT /note="F -> L (in dbSNP:rs12108463)"
FT /id="VAR_053539"
SQ SEQUENCE 174 AA; 19741 MW; 8ABD8138769FA815 CRC64;
MLRTESCRPR SPAGQVAAAS PLLLLLLLLA WCAGACRGAP ILPQGLQPEQ QLQLWNEIDD
TCSSFLSIDS QPQASNALEE LCFMIMGMLP KPQEQDEKDN TKRFLFHYSK TQKLGKSNVV
SSVVHPLLQL VPHLHERRMK RFRVDEEFQS PFASQSRGYF LFRPRNGRRS AGFI
