NMU_MOUSE
ID NMU_MOUSE Reviewed; 174 AA.
AC Q9QXK8;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Neuromedin-U;
DE Contains:
DE RecName: Full=Neuromedin precursor-related peptide 36 {ECO:0000250|UniProtKB:P12760};
DE Short=NURP36 {ECO:0000250|UniProtKB:P12760};
DE Contains:
DE RecName: Full=Neuromedin precursor-related peptide 33 {ECO:0000250|UniProtKB:P12760};
DE Short=NURP33 {ECO:0000250|UniProtKB:P12760};
DE Contains:
DE RecName: Full=Neuromedin-U-23;
DE Short=NmU-23;
DE Flags: Precursor;
GN Name=Nmu;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Sharma S.K., Bloom S.R.;
RT "Molecular cloning and characterisation of the cDNA encoding the mouse
RT neuromedin U (NmU) precursor peptide.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: [Neuromedin-U-23]: Ligand for receptors NMUR1 and NMUR2 (By
CC similarity). Stimulates muscle contractions of specific regions of the
CC gastrointestinal tract. {ECO:0000250|UniProtKB:P12760}.
CC -!- FUNCTION: [Neuromedin precursor-related peptide 33]: Does not function
CC as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin
CC release although its potency is much lower than that of neuromedin
CC precursor-related peptide 36. {ECO:0000250|UniProtKB:P12760}.
CC -!- FUNCTION: [Neuromedin precursor-related peptide 36]: Does not function
CC as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin
CC release from lactotroph cells in the pituitary gland, probably via the
CC hypothalamic dopaminergic system. {ECO:0000250|UniProtKB:P12760}.
CC -!- FUNCTION: Stimulates muscle contractions of specific regions of the
CC gastrointestinal tract. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
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DR EMBL; AF203444; AAF20198.1; -; mRNA.
DR EMBL; AK077478; BAC36820.1; -; mRNA.
DR CCDS; CCDS19362.1; -.
DR RefSeq; NP_062388.1; NM_019515.1.
DR AlphaFoldDB; Q9QXK8; -.
DR STRING; 10090.ENSMUSP00000031146; -.
DR iPTMnet; Q9QXK8; -.
DR PhosphoSitePlus; Q9QXK8; -.
DR PaxDb; Q9QXK8; -.
DR PRIDE; Q9QXK8; -.
DR ProteomicsDB; 252975; -.
DR Antibodypedia; 12370; 177 antibodies from 27 providers.
DR DNASU; 56183; -.
DR Ensembl; ENSMUST00000031146; ENSMUSP00000031146; ENSMUSG00000029236.
DR GeneID; 56183; -.
DR KEGG; mmu:56183; -.
DR UCSC; uc008xuw.1; mouse.
DR CTD; 10874; -.
DR MGI; MGI:1860476; Nmu.
DR VEuPathDB; HostDB:ENSMUSG00000029236; -.
DR eggNOG; ENOG502S1QB; Eukaryota.
DR GeneTree; ENSGT00510000048726; -.
DR HOGENOM; CLU_090356_0_0_1; -.
DR InParanoid; Q9QXK8; -.
DR OMA; CFMVMGI; -.
DR OrthoDB; 1515830at2759; -.
DR PhylomeDB; Q9QXK8; -.
DR TreeFam; TF338319; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 56183; 3 hits in 74 CRISPR screens.
DR PRO; PR:Q9QXK8; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9QXK8; protein.
DR Bgee; ENSMUSG00000029236; Expressed in lip and 26 other tissues.
DR ExpressionAtlas; Q9QXK8; baseline and differential.
DR Genevisible; Q9QXK8; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043195; C:terminal bouton; ISO:MGI.
DR GO; GO:0042922; F:neuromedin U receptor binding; ISO:MGI.
DR GO; GO:0031839; F:type 1 neuromedin U receptor binding; ISO:MGI.
DR GO; GO:0031840; F:type 2 neuromedin U receptor binding; ISO:MGI.
DR GO; GO:0042755; P:eating behavior; ISO:MGI.
DR GO; GO:0097009; P:energy homeostasis; IMP:UniProtKB.
DR GO; GO:0001696; P:gastric acid secretion; ISO:MGI.
DR GO; GO:1903999; P:negative regulation of eating behavior; ISO:MGI.
DR GO; GO:2000252; P:negative regulation of feeding behavior; ISO:MGI.
DR GO; GO:0060455; P:negative regulation of gastric acid secretion; ISO:MGI.
DR GO; GO:0120061; P:negative regulation of gastric emptying; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0010460; P:positive regulation of heart rate; ISO:MGI.
DR GO; GO:0031652; P:positive regulation of heat generation; ISO:MGI.
DR GO; GO:0046887; P:positive regulation of hormone secretion; ISO:MGI.
DR GO; GO:1902722; P:positive regulation of prolactin secretion; ISO:MGI.
DR GO; GO:1904058; P:positive regulation of sensory perception of pain; ISO:MGI.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; ISO:MGI.
DR GO; GO:0120069; P:positive regulation of stomach fundus smooth muscle contraction; ISO:MGI.
DR GO; GO:0050806; P:positive regulation of synaptic transmission; ISO:MGI.
DR GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; ISO:MGI.
DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; ISO:MGI.
DR GO; GO:0060259; P:regulation of feeding behavior; IMP:UniProtKB.
DR GO; GO:2000821; P:regulation of grooming behavior; IDA:UniProtKB.
DR GO; GO:0019233; P:sensory perception of pain; ISO:MGI.
DR GO; GO:0001659; P:temperature homeostasis; IMP:UniProtKB.
DR InterPro; IPR018070; Neuromedin-U_amidation-site.
DR InterPro; IPR042384; NMU.
DR InterPro; IPR008200; NMU_C.
DR PANTHER; PTHR15390; PTHR15390; 1.
DR Pfam; PF02070; NMU; 1.
DR SMART; SM00084; NMU; 1.
DR PROSITE; PS00967; NMU; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide; Oxidation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..37
FT /evidence="ECO:0000255"
FT PROPEP 38..105
FT /evidence="ECO:0000250"
FT /id="PRO_0000019775"
FT PEPTIDE 106..141
FT /note="Neuromedin precursor-related peptide 36"
FT /evidence="ECO:0000250|UniProtKB:P12760"
FT /id="PRO_0000445767"
FT PEPTIDE 106..138
FT /note="Neuromedin precursor-related peptide 33"
FT /evidence="ECO:0000250|UniProtKB:P12760"
FT /id="PRO_0000445768"
FT PEPTIDE 144..166
FT /note="Neuromedin-U-23"
FT /id="PRO_0000019776"
FT PROPEP 170..174
FT /evidence="ECO:0000250"
FT /id="PRO_0000019777"
FT MOD_RES 141
FT /note="Methionine sulfoxide; partial"
FT /evidence="ECO:0000250|UniProtKB:P12760"
FT MOD_RES 166
FT /note="Asparagine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 174 AA; 19429 MW; D6E86FD7F5731130 CRC64;
MSRAAGHRPG LSAGQLAAAT ASPLLSLLLL LACCADACKG VPISPQRLQP EQELQLWNEI
HEACASFLSI DSRPQASVAL RELCRIVMEI SQKPQEQSEK DNTKRFLFHY SKTQKLGNSN
VVSSVVHPLL QLVPQLHERR MKRFKAEYQS PSVGQSKGYF LFRPRNGKRS TSFI
