ID   NMU_PIG                 Reviewed;          25 AA.
AC   P34964;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Neuromedin-U-25;
DE            Short=NmU-25;
DE   Contains:
DE     RecName: Full=Neuromedin-U-8;
DE              Short=NmU-8;
GN   Name=NMU;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ASN-25.
RC   TISSUE=Spinal cord;
RX   PubMed=3839674; DOI=10.1016/0006-291x(85)91726-7;
RA   Minamino N., Kangawa K., Matsuo H.;
RT   "Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive
RT   peptides identified in porcine spinal cord.";
RL   Biochem. Biophys. Res. Commun. 130:1078-1085(1985).
CC   -!- FUNCTION: Stimulates uterine smooth muscle contraction and causes
CC       selective vasoconstriction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
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DR   AlphaFoldDB; P34964; -.
DR   STRING; 9823.ENSSSCP00000025674; -.
DR   PaxDb; P34964; -.
DR   eggNOG; ENOG502S1QB; Eukaryota.
DR   HOGENOM; CLU_221025_0_0_1; -.
DR   InParanoid; P34964; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; P34964; SS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006940; P:regulation of smooth muscle contraction; IEA:InterPro.
DR   InterPro; IPR018070; Neuromedin-U_amidation-site.
DR   InterPro; IPR008200; NMU_C.
DR   Pfam; PF02070; NMU; 1.
DR   SMART; SM00084; NMU; 1.
DR   PROSITE; PS00967; NMU; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Reference proteome; Secreted.
FT   PEPTIDE         1..25
FT                   /note="Neuromedin-U-25"
FT                   /id="PRO_0000019778"
FT   PEPTIDE         18..25
FT                   /note="Neuromedin-U-8"
FT                   /id="PRO_0000019779"
FT   MOD_RES         25
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:3839674"
SQ   SEQUENCE   25 AA;  3144 MW;  46A065C120F193B9 CRC64;
     FKVDEEFQGP IVSQNRRYFL FRPRN