ID   NMU_RABIT               Reviewed;          25 AA.
AC   P34965;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Neuromedin-U-25;
DE            Short=NmU-25;
GN   Name=NMU;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ASN-25.
RC   TISSUE=Small intestine;
RX   PubMed=1882085; DOI=10.1016/0167-0115(91)90213-z;
RA   Kage R., O'Harte F., Thim L., Conlon J.M.;
RT   "Rabbit neuromedin U-25: lack of conservation of a posttranslational
RT   processing site.";
RL   Regul. Pept. 33:191-198(1991).
CC   -!- FUNCTION: Stimulates uterine smooth muscle contraction and causes
CC       selective vasoconstriction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A60067; A60067.
DR   AlphaFoldDB; P34965; -.
DR   STRING; 9986.ENSOCUP00000014722; -.
DR   eggNOG; ENOG502S1QB; Eukaryota.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006940; P:regulation of smooth muscle contraction; IEA:InterPro.
DR   InterPro; IPR018070; Neuromedin-U_amidation-site.
DR   InterPro; IPR008200; NMU_C.
DR   Pfam; PF02070; NMU; 1.
DR   SMART; SM00084; NMU; 1.
DR   PROSITE; PS00967; NMU; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Reference proteome;
KW   Secreted.
FT   PEPTIDE         1..25
FT                   /note="Neuromedin-U-25"
FT                   /id="PRO_0000044073"
FT   MOD_RES         25
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:1882085"
SQ   SEQUENCE   25 AA;  3036 MW;  4DD0BFEBEFE48A5B CRC64;
     FPVDEEFQSP FGSRSRGYFL FRPRN