ID   NMU_RANTE               Reviewed;          25 AA.
AC   P20056;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Neuromedin-U-25;
DE            Short=NmU-25;
OS   Rana temporaria (European common frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=8407;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ASN-25.
RC   TISSUE=Intestine;
RX   PubMed=2592357; DOI=10.1016/s0021-9258(19)30018-3;
RA   Domin J., Yiangou Y.G., Spokes R.A., Aitken A., Parmar K.B.,
RA   Chrysanthou B.J., Bloom S.R.;
RT   "The distribution, purification, and pharmacological action of an amphibian
RT   neuromedin U.";
RL   J. Biol. Chem. 264:20881-20885(1989).
CC   -!- FUNCTION: Stimulates uterine smooth muscle contraction and causes
CC       selective vasoconstriction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NmU family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A34179; A34179.
DR   AlphaFoldDB; P20056; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006940; P:regulation of smooth muscle contraction; IEA:InterPro.
DR   InterPro; IPR018070; Neuromedin-U_amidation-site.
DR   InterPro; IPR008200; NMU_C.
DR   Pfam; PF02070; NMU; 1.
DR   SMART; SM00084; NMU; 1.
DR   PROSITE; PS00967; NMU; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..25
FT                   /note="Neuromedin-U-25"
FT                   /id="PRO_0000044075"
FT   MOD_RES         25
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:2592357"
SQ   SEQUENCE   25 AA;  2832 MW;  6A01D89F6DA06FD4 CRC64;
     LKPDEELQGP GGVLSRGYFV FRPRN