NNAT_MOUSE
ID NNAT_MOUSE Reviewed; 81 AA.
AC Q61979; Q548Q0; Q61980; Q61981;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Neuronatin;
GN Name=Nnat;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=NMRI; TISSUE=Brain;
RX PubMed=7556909; DOI=10.1006/dbio.1995.1261;
RA Wijnholds J., Chowdhury K., Wehr R., Gruss P.;
RT "Segment-specific expression of the neuronatin gene during early hindbrain
RT development.";
RL Dev. Biol. 171:73-84(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Aparicio S.A.J.R., John R.M., Surani A.M., Hawker K.;
RT "Structure of the murine imprinted locus for neuronatin reveals an unusual
RT organisation.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May participate in the maintenance of segment identity in the
CC hindbrain and pituitary development, and maturation or maintenance of
CC the overall structure of the nervous system.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q61979-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q61979-3; Sequence=VSP_004333;
CC -!- TISSUE SPECIFICITY: Highest in brain and ovary.
CC -!- DEVELOPMENTAL STAGE: Expressed in rhombomeres 3 and 5 during early
CC hindbrain development and in the floor of the foregut pocket. Also
CC expressed in the early Rathke pouch, derived adenohypophysis, and
CC developing inner ear. During later embryogenesis, strongly expressed in
CC the major part of the central and peripheral nervous system.
CC -!- SIMILARITY: Belongs to the neuronatin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA58551.1; Type=Miscellaneous discrepancy; Note=Incorrect N-terminal sequence due to reversal of the first 22 base pairs of the cDNA.; Evidence={ECO:0000305};
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DR EMBL; X83568; CAA58551.1; ALT_SEQ; mRNA.
DR EMBL; X83569; CAA58552.1; -; mRNA.
DR EMBL; X83570; CAA58553.1; -; mRNA.
DR EMBL; AF303656; AAL01185.1; -; Genomic_DNA.
DR EMBL; AK160626; BAE35925.1; -; mRNA.
DR EMBL; AL672259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036984; AAH36984.1; -; mRNA.
DR CCDS; CCDS38306.1; -. [Q61979-1]
DR CCDS; CCDS38307.1; -. [Q61979-3]
DR PIR; S51082; S51082.
DR PIR; S51083; S51083.
DR PIR; S51084; S51084.
DR RefSeq; NP_001278057.1; NM_001291128.1.
DR RefSeq; NP_001278058.1; NM_001291129.1.
DR RefSeq; NP_001278059.1; NM_001291130.1.
DR RefSeq; NP_035053.1; NM_010923.3. [Q61979-1]
DR RefSeq; NP_851291.1; NM_180960.3. [Q61979-3]
DR AlphaFoldDB; Q61979; -.
DR STRING; 10090.ENSMUSP00000105152; -.
DR iPTMnet; Q61979; -.
DR PhosphoSitePlus; Q61979; -.
DR PaxDb; Q61979; -.
DR PRIDE; Q61979; -.
DR ProteomicsDB; 253087; -. [Q61979-1]
DR DNASU; 18111; -.
DR Ensembl; ENSMUST00000109526; ENSMUSP00000105152; ENSMUSG00000067786. [Q61979-1]
DR Ensembl; ENSMUST00000153739; ENSMUSP00000129821; ENSMUSG00000067786. [Q61979-3]
DR GeneID; 18111; -.
DR KEGG; mmu:18111; -.
DR UCSC; uc008npe.2; mouse. [Q61979-1]
DR CTD; 4826; -.
DR MGI; MGI:104716; Nnat.
DR VEuPathDB; HostDB:ENSMUSG00000067786; -.
DR eggNOG; ENOG502TDP2; Eukaryota.
DR GeneTree; ENSGT00940000166501; -.
DR HOGENOM; CLU_152636_0_0_1; -.
DR InParanoid; Q61979; -.
DR OMA; VMGERRQ; -.
DR OrthoDB; 1502560at2759; -.
DR PhylomeDB; Q61979; -.
DR TreeFam; TF338710; -.
DR BioGRID-ORCS; 18111; 3 hits in 68 CRISPR screens.
DR ChiTaRS; Nnat; mouse.
DR PRO; PR:Q61979; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q61979; protein.
DR Bgee; ENSMUSG00000067786; Expressed in median eminence of neurohypophysis and 269 other tissues.
DR ExpressionAtlas; Q61979; baseline and differential.
DR Genevisible; Q61979; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0051649; P:establishment of localization in cell; IMP:MGI.
DR GO; GO:0030073; P:insulin secretion; IMP:MGI.
DR GO; GO:0032024; P:positive regulation of insulin secretion; IMP:MGI.
DR GO; GO:0032880; P:regulation of protein localization; IMP:MGI.
DR GO; GO:0009749; P:response to glucose; IMP:MGI.
DR InterPro; IPR024885; Neuronatin.
DR PANTHER; PTHR15285; PTHR15285; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; Reference proteome.
FT CHAIN 1..81
FT /note="Neuronatin"
FT /id="PRO_0000096883"
FT VAR_SEQ 25..51
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7556909"
FT /id="VSP_004333"
SQ SEQUENCE 81 AA; 9211 MW; 067086DB0A4E3D20 CRC64;
MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS EVFRYSLQKL
AHTVSRTGRQ VLGERRQRAP N
