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NNAT_RAT
ID   NNAT_RAT                Reviewed;          81 AA.
AC   Q62649; A0JPK6; Q62663;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Neuronatin;
GN   Name=Nnat;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
RC   STRAIN=Fischer 344; TISSUE=Brain;
RX   PubMed=8024565; DOI=10.1006/bbrc.1994.1836;
RA   Joseph R., Dou D., Tsang W.;
RT   "Molecular cloning of a novel mRNA (neuronatin) that is highly expressed in
RT   neonatal mammalian brain.";
RL   Biochem. Biophys. Res. Commun. 201:1227-1234(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
RC   STRAIN=Fischer 344; TISSUE=Brain;
RA   Joseph R., Dou D., Tsang W.;
RT   "Molecular cloning of neuronatin: alternatively spliced forms of a novel
RT   mammalian developmental gene.";
RL   Nucleic Acids Symp. Ser. 30:15-15(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
RC   STRAIN=Fischer 344; TISSUE=Brain;
RX   PubMed=7496812; DOI=10.1016/0006-8993(95)00621-v;
RA   Joseph R., Dou D., Tsang W.;
RT   "Neuronatin mRNA: alternatively spliced forms of a novel brain-specific
RT   mammalian developmental gene.";
RL   Brain Res. 690:92-98(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May participate in the maintenance of segment identity in the
CC       hindbrain and pituitary development, and maturation or maintenance of
CC       the overall structure of the nervous system.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Alpha;
CC         IsoId=Q62649-1; Sequence=Displayed;
CC       Name=Beta;
CC         IsoId=Q62649-2; Sequence=VSP_004334;
CC   -!- TISSUE SPECIFICITY: Brain.
CC   -!- DEVELOPMENTAL STAGE: Appears in the mid embryonic period and becomes
CC       abundant at E16-19. Postnatally its expression decline and only minimal
CC       levels were present in adulthood.
CC   -!- SIMILARITY: Belongs to the neuronatin family. {ECO:0000305}.
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DR   EMBL; U08290; AAA92998.1; -; mRNA.
DR   EMBL; U09785; AAA92999.1; -; mRNA.
DR   EMBL; BC127473; AAI27474.1; -; mRNA.
DR   PIR; I60594; I60594.
DR   PIR; JC2325; JC2325.
DR   RefSeq; NP_001257796.1; NM_001270867.1.
DR   RefSeq; NP_446053.1; NM_053601.2. [Q62649-1]
DR   RefSeq; NP_859015.1; NM_181687.2. [Q62649-2]
DR   AlphaFoldDB; Q62649; -.
DR   SMR; Q62649; -.
DR   STRING; 10116.ENSRNOP00000064325; -.
DR   PaxDb; Q62649; -.
DR   PRIDE; Q62649; -.
DR   GeneID; 94270; -.
DR   KEGG; rno:94270; -.
DR   UCSC; RGD:620155; rat. [Q62649-1]
DR   CTD; 4826; -.
DR   RGD; 620155; Nnat.
DR   VEuPathDB; HostDB:ENSRNOG00000024923; -.
DR   eggNOG; ENOG502TDP2; Eukaryota.
DR   HOGENOM; CLU_152636_0_0_1; -.
DR   InParanoid; Q62649; -.
DR   OMA; VMGERRQ; -.
DR   OrthoDB; 1502560at2759; -.
DR   PhylomeDB; Q62649; -.
DR   PRO; PR:Q62649; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000024923; Expressed in cerebellum and 20 other tissues.
DR   Genevisible; Q62649; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0007420; P:brain development; IEP:RGD.
DR   GO; GO:0030182; P:neuron differentiation; IEP:RGD.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; ISO:RGD.
DR   GO; GO:0032880; P:regulation of protein localization; ISO:RGD.
DR   GO; GO:0009749; P:response to glucose; ISO:RGD.
DR   InterPro; IPR024885; Neuronatin.
DR   PANTHER; PTHR15285; PTHR15285; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; Reference proteome.
FT   CHAIN           1..81
FT                   /note="Neuronatin"
FT                   /id="PRO_0000096884"
FT   VAR_SEQ         25..51
FT                   /note="Missing (in isoform Beta)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:7496812, ECO:0000303|Ref.2"
FT                   /id="VSP_004334"
SQ   SEQUENCE   81 AA;  9220 MW;  067086DB1D7E3D20 CRC64;
     MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS EVFRYSLQKL
     AHTVSRTGRQ VLGERRHRAP N
 
 
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