NNAT_RAT
ID NNAT_RAT Reviewed; 81 AA.
AC Q62649; A0JPK6; Q62663;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Neuronatin;
GN Name=Nnat;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
RC STRAIN=Fischer 344; TISSUE=Brain;
RX PubMed=8024565; DOI=10.1006/bbrc.1994.1836;
RA Joseph R., Dou D., Tsang W.;
RT "Molecular cloning of a novel mRNA (neuronatin) that is highly expressed in
RT neonatal mammalian brain.";
RL Biochem. Biophys. Res. Commun. 201:1227-1234(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
RC STRAIN=Fischer 344; TISSUE=Brain;
RA Joseph R., Dou D., Tsang W.;
RT "Molecular cloning of neuronatin: alternatively spliced forms of a novel
RT mammalian developmental gene.";
RL Nucleic Acids Symp. Ser. 30:15-15(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
RC STRAIN=Fischer 344; TISSUE=Brain;
RX PubMed=7496812; DOI=10.1016/0006-8993(95)00621-v;
RA Joseph R., Dou D., Tsang W.;
RT "Neuronatin mRNA: alternatively spliced forms of a novel brain-specific
RT mammalian developmental gene.";
RL Brain Res. 690:92-98(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May participate in the maintenance of segment identity in the
CC hindbrain and pituitary development, and maturation or maintenance of
CC the overall structure of the nervous system.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Alpha;
CC IsoId=Q62649-1; Sequence=Displayed;
CC Name=Beta;
CC IsoId=Q62649-2; Sequence=VSP_004334;
CC -!- TISSUE SPECIFICITY: Brain.
CC -!- DEVELOPMENTAL STAGE: Appears in the mid embryonic period and becomes
CC abundant at E16-19. Postnatally its expression decline and only minimal
CC levels were present in adulthood.
CC -!- SIMILARITY: Belongs to the neuronatin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U08290; AAA92998.1; -; mRNA.
DR EMBL; U09785; AAA92999.1; -; mRNA.
DR EMBL; BC127473; AAI27474.1; -; mRNA.
DR PIR; I60594; I60594.
DR PIR; JC2325; JC2325.
DR RefSeq; NP_001257796.1; NM_001270867.1.
DR RefSeq; NP_446053.1; NM_053601.2. [Q62649-1]
DR RefSeq; NP_859015.1; NM_181687.2. [Q62649-2]
DR AlphaFoldDB; Q62649; -.
DR SMR; Q62649; -.
DR STRING; 10116.ENSRNOP00000064325; -.
DR PaxDb; Q62649; -.
DR PRIDE; Q62649; -.
DR GeneID; 94270; -.
DR KEGG; rno:94270; -.
DR UCSC; RGD:620155; rat. [Q62649-1]
DR CTD; 4826; -.
DR RGD; 620155; Nnat.
DR VEuPathDB; HostDB:ENSRNOG00000024923; -.
DR eggNOG; ENOG502TDP2; Eukaryota.
DR HOGENOM; CLU_152636_0_0_1; -.
DR InParanoid; Q62649; -.
DR OMA; VMGERRQ; -.
DR OrthoDB; 1502560at2759; -.
DR PhylomeDB; Q62649; -.
DR PRO; PR:Q62649; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000024923; Expressed in cerebellum and 20 other tissues.
DR Genevisible; Q62649; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0007420; P:brain development; IEP:RGD.
DR GO; GO:0030182; P:neuron differentiation; IEP:RGD.
DR GO; GO:0032024; P:positive regulation of insulin secretion; ISO:RGD.
DR GO; GO:0032880; P:regulation of protein localization; ISO:RGD.
DR GO; GO:0009749; P:response to glucose; ISO:RGD.
DR InterPro; IPR024885; Neuronatin.
DR PANTHER; PTHR15285; PTHR15285; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; Reference proteome.
FT CHAIN 1..81
FT /note="Neuronatin"
FT /id="PRO_0000096884"
FT VAR_SEQ 25..51
FT /note="Missing (in isoform Beta)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:7496812, ECO:0000303|Ref.2"
FT /id="VSP_004334"
SQ SEQUENCE 81 AA; 9220 MW; 067086DB1D7E3D20 CRC64;
MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS EVFRYSLQKL
AHTVSRTGRQ VLGERRHRAP N