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NNF1_SCHPO
ID   NNF1_SCHPO              Reviewed;         145 AA.
AC   Q09858;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Kinetochore protein nnf1;
DE   AltName: Full=NMS complex subunit nnf1;
GN   Name=nnf1; ORFNames=SPAC29E6.04, SPAC30.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   IDENTIFICATION IN THE NMS COMPLEX.
RX   PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
RA   Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
RT   "Molecular analysis of kinetochore architecture in fission yeast.";
RL   EMBO J. 24:2919-2930(2005).
RN   [3]
RP   IDENTIFICATION IN THE NMS COMPLEX.
RX   PubMed=17035632; DOI=10.1091/mbc.e06-05-0388;
RA   Hayashi A., Asakawa H., Haraguchi T., Hiraoka Y.;
RT   "Reconstruction of the kinetochore during meiosis in fission yeast
RT   Schizosaccharomyces pombe.";
RL   Mol. Biol. Cell 17:5173-5184(2006).
CC   -!- FUNCTION: Acts as a component of the NMS (Ndc80-MIND-Spc7) super
CC       complex which has a role in kinetochore function during late meiotic
CC       prophase and throughout the mitotic cell cycle.
CC   -!- SUBUNIT: Component of the NMS super complex which consists of mis12,
CC       mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25.
CC       {ECO:0000269|PubMed:16079914, ECO:0000269|PubMed:17035632}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P47149}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P47149}.
CC       Note=Associated with the kinetochore. {ECO:0000250|UniProtKB:P47149}.
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DR   EMBL; Z66525; CAA91426.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAB66467.1; -; Genomic_DNA.
DR   PIR; S62510; S62510.
DR   RefSeq; NP_594562.2; NM_001019991.2.
DR   PDB; 5WWL; X-ray; 2.40 A; N=1-140.
DR   PDBsum; 5WWL; -.
DR   AlphaFoldDB; Q09858; -.
DR   SMR; Q09858; -.
DR   STRING; 4896.SPAC29E6.04.1; -.
DR   MaxQB; Q09858; -.
DR   PaxDb; Q09858; -.
DR   GeneID; 2541667; -.
DR   KEGG; spo:SPAC29E6.04; -.
DR   PomBase; SPAC29E6.04; nnf1.
DR   eggNOG; ENOG502S9JT; Eukaryota.
DR   InParanoid; Q09858; -.
DR   PhylomeDB; Q09858; -.
DR   PRO; PR:Q09858; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000776; C:kinetochore; IDA:PomBase.
DR   GO; GO:0031617; C:NMS complex; IDA:PomBase.
DR   GO; GO:0000818; C:nuclear MIS12/MIND complex; IDA:PomBase.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IC:PomBase.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   GO; GO:0051455; P:monopolar spindle attachment to meiosis I kinetochore; IC:PomBase.
DR   InterPro; IPR016851; Nnf1.
DR   InterPro; IPR007128; PMF1/Nnf1.
DR   PANTHER; PTHR15459; PTHR15459; 1.
DR   Pfam; PF03980; Nnf1; 1.
DR   PIRSF; PIRSF027153; Nnf1p; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; Cell division; Centromere; Chromosome;
KW   Kinetochore; Meiosis; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..145
FT                   /note="Kinetochore protein nnf1"
FT                   /id="PRO_0000116422"
FT   HELIX           4..21
FT                   /evidence="ECO:0007829|PDB:5WWL"
FT   HELIX           25..30
FT                   /evidence="ECO:0007829|PDB:5WWL"
FT   HELIX           38..66
FT                   /evidence="ECO:0007829|PDB:5WWL"
FT   HELIX           69..88
FT                   /evidence="ECO:0007829|PDB:5WWL"
FT   HELIX           107..140
FT                   /evidence="ECO:0007829|PDB:5WWL"
SQ   SEQUENCE   145 AA;  16808 MW;  6FA7859AE1C93973 CRC64;
     MTSRKEQLDA FLSRTLSETI AHIPLEKFAQ CFPSMKKGKV IAVIHQQLIE FFEKSCKQEY
     ANLIKERDLN KKLDMLDECI HDAEFRKLHG ESEVDISNKQ PQEILKAHLY SHKRELLDKL
     NQDLLDIDKE NEGLSTQIAA GRKSN
 
 
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