NNJA1_ORYSJ
ID NNJA1_ORYSJ Reviewed; 401 AA.
AC Q10Q07; C7IZR5; Q0DU04;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Ninja-family protein MODD {ECO:0000305};
DE AltName: Full=Protein MEDIATOR OF OSBZIP46 DEACTIVATION AND DEGRADATION {ECO:0000303|PubMed:27468891};
GN Name=MODD {ECO:0000303|PubMed:27468891};
GN OrderedLocusNames=Os03g0214200, LOC_Os03g11550;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP FUNCTION, INTERACTION WITH BZIP46; TPR3 AND PUB70, SUBCELLULAR LOCATION,
RP INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=27468891; DOI=10.1105/tpc.16.00171;
RA Tang N., Ma S., Zong W., Yang N., Lv Y., Yan C., Guo Z., Li J., Li X.,
RA Xiang Y., Song H., Xiao J., Li X., Xiong L.;
RT "MODD mediates deactivation and degradation of OsbZIP46 to negatively
RT regulate ABA signaling and drought resistance in rice.";
RL Plant Cell 28:2161-2177(2016).
CC -!- FUNCTION: Acts as negative regulator of abscisic acid (ABA) signaling
CC and drought tolerance. Mediates deactivation and degradation of BZIP46,
CC a positive regulator of ABA signaling and drought stress tolerance.
CC Represses BZIP46 activity via interaction with the TPR3-HDAC1
CC corepressor complex and down-regulation of the histone acetylation
CC level at BZIP46 target genes. Promotes BZIP46 degradation via
CC interaction with the U-box type ubiquitin E3 ligase PUB70.
CC {ECO:0000269|PubMed:27468891}.
CC -!- SUBUNIT: Interacts with BZIP46, TPR3 and PUB70.
CC {ECO:0000269|PubMed:27468891}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27468891}.
CC -!- INDUCTION: Induced by abscisic acid (ABA) and drought stress.
CC {ECO:0000269|PubMed:27468891}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant plants exhibit increased abscisic acid (ABA)
CC sensitivity and drought resistance. {ECO:0000269|PubMed:27468891}.
CC -!- SIMILARITY: Belongs to the Ninja family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF11284.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DP000009; ABF94628.1; -; Genomic_DNA.
DR EMBL; AP008209; BAF11284.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008209; BAH92041.1; -; Genomic_DNA.
DR EMBL; AP014959; BAS82953.1; -; Genomic_DNA.
DR EMBL; AK100623; BAG94685.1; -; mRNA.
DR RefSeq; XP_015632992.1; XM_015777506.1.
DR AlphaFoldDB; Q10Q07; -.
DR STRING; 4530.OS03T0214200-01; -.
DR PaxDb; Q10Q07; -.
DR PRIDE; Q10Q07; -.
DR EnsemblPlants; Os03t0214200-01; Os03t0214200-01; Os03g0214200.
DR GeneID; 9268873; -.
DR Gramene; Os03t0214200-01; Os03t0214200-01; Os03g0214200.
DR KEGG; osa:9268873; -.
DR eggNOG; ENOG502QW6K; Eukaryota.
DR HOGENOM; CLU_034695_0_0_1; -.
DR InParanoid; Q10Q07; -.
DR OMA; RTNAMED; -.
DR OrthoDB; 1469925at2759; -.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR ExpressionAtlas; Q10Q07; baseline and differential.
DR Genevisible; Q10Q07; OS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR032310; NINJA_B.
DR InterPro; IPR031307; Ninja_fam.
DR InterPro; IPR012463; Ninja_motif.
DR InterPro; IPR032308; TDBD.
DR PANTHER; PTHR31413; PTHR31413; 1.
DR Pfam; PF07897; EAR; 1.
DR Pfam; PF16136; NINJA_B; 1.
DR Pfam; PF16135; TDBD; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..401
FT /note="Ninja-family protein MODD"
FT /id="PRO_0000369627"
FT REGION 95..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 401 AA; 42644 MW; 4A0248E40F2B6A54 CRC64;
MEGFSRDLLC GIGKGGDGPR GEVRPRVDME AEEVELNLGL SLGGRFGLDR RGEKLARSSS
VAAILAAPTE PSAPPSGLFR TSSLPTVAAA EAAKKQGVDE LNCRRPSGGA EAEPAAARLP
ASGSPSSGSS DGEGRRLEVN MTDTLMRTSS LPAGIEDEWR KRKEAQSLKR LEVKRKRIER
RNSLTSNISK EAVGQILEEM NAGAEKVESC DDVATGNKKT GGNVNHSSDR NRCTGLPPVH
RATYTQQRGS LSGIPTKHIP AMKGSADAEE HNVPSAATEH RNGAAIATPP FSALAVRAVA
LASRGEQLRA TGRVAARAKS MGDVERIMMQ EMPCVCTKGL PNGKRVEGFL YKYRKGEEVR
IVCVCHGSFL TPAEFVKHAG GGDVANPLRH IVVNPIPPSL Y
