ID   NOA1_BOVIN              Reviewed;         694 AA.
AC   Q32LB9;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Nitric oxide-associated protein 1;
GN   Name=NOA1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in regulation of mitochondrial protein translation
CC       and respiration. Plays a role in mitochondria-mediated cell death. May
CC       act as a scaffolding protein or stabilizer of respiratory chain
CC       supercomplexes. Binds GTP (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer or multimer. Interacts with mitochondrial complex I,
CC       DAP3, MRPL12 and MRPS27 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOA1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR   EMBL; BC109654; AAI09655.1; -; mRNA.
DR   RefSeq; NP_001033277.1; NM_001038188.2.
DR   AlphaFoldDB; Q32LB9; -.
DR   SMR; Q32LB9; -.
DR   STRING; 9913.ENSBTAP00000025792; -.
DR   PaxDb; Q32LB9; -.
DR   GeneID; 539773; -.
DR   KEGG; bta:539773; -.
DR   CTD; 539773; -.
DR   eggNOG; KOG1249; Eukaryota.
DR   InParanoid; Q32LB9; -.
DR   OrthoDB; 612803at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR   GO; GO:0010941; P:regulation of cell death; ISS:UniProtKB.
DR   GO; GO:0043457; P:regulation of cellular respiration; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; GTP-binding; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..694
FT                   /note="Nitric oxide-associated protein 1"
FT                   /id="PRO_0000232509"
FT   DOMAIN          202..504
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   REGION          38..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..118
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         77
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NC60"
SQ   SEQUENCE   694 AA;  77243 MW;  0F5EBA762FF406CF CRC64;
     MLPAPLARRL LCGFLRGPTP IVTRNGVRET LLERRCATDY SSRHSAGLGR GLPRGATATG
     GNPGGADLEE SFLFPEYVLD SESEATLQDQ LRELQQRQEE EERRIEQQRE ERRQQKLGAG
     RRVHQVVGHP DPTVPPSGQN CSGCGAELHC QDPGVPGYLP SEKFNSAVAE EGGLERTVCQ
     RCWLLVHHRR ALRLQVSQGQ FLELVSAALR RPEPALVLYM VDLLDLPDTL LPHLPALVGP
     KQLIVLGNKV DLLPQDTPNY RQRLRERLWD ECIGAGLLPP RGYRRAQRSS GDRPRGGEDN
     ANLPSKSSTV LRDVRLISAK TGYGVEELIS ALQRSWRYRG DVYLVGSTNA GKSTLFNTLL
     ESDYCIAKGA EAIDRATISP WPGTTLNLLK FPICNPTPYR MFQRQKRLKR DATEAEEDLS
     QQEQNKLNLL KKHGYLVGRV GRTFSYSEAQ KDKAAFEFDA DSFAFDMGNE PVLAADKSTK
     RVELTPEDVK DAHWFYDTPG ITKENCILSL LTEKEVNIVL PTHSIIPRTF MLKPGMVLFL
     GALGRIDFLK GNQSAWFTVV ASNFLPVHIT SLDKADTMYQ KHAGHTLLKV PVGGEERMAG
     FPPLVAEDIT LDEGLGESEA VADIKLSSAG WVAVTPQFKD TLTLRGYTPQ GTVLTVRRPL
     LPHIVNIKGK RIKGSVAYKT KRPPALMYNL QKKR