ID   NOC2L_CAEBR             Reviewed;         719 AA.
AC   A8WTM7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Nucleolar complex protein 2 homolog;
DE            Short=Protein NOC2 homolog;
DE   AltName: Full=Proximal proliferation in germline protein 2;
GN   Name=pro-2; ORFNames=CBG02729;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Required for normal somatic gonad development and for
CC       regulation of germline development and proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOC2 family. {ECO:0000305}.
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DR   EMBL; HE601438; CAP23839.3; -; Genomic_DNA.
DR   RefSeq; XP_002630987.1; XM_002630941.1.
DR   AlphaFoldDB; A8WTM7; -.
DR   STRING; 6238.CBG02729; -.
DR   EnsemblMetazoa; CBG02729.1; CBG02729.1; WBGene00025730.
DR   GeneID; 8572502; -.
DR   KEGG; cbr:CBG_02729; -.
DR   CTD; 8572502; -.
DR   WormBase; CBG02729; CBP00760; WBGene00025730; Cbr-pro-2.
DR   eggNOG; KOG2256; Eukaryota.
DR   HOGENOM; CLU_399139_0_0_1; -.
DR   InParanoid; A8WTM7; -.
DR   OMA; FPLRFHC; -.
DR   OrthoDB; 1194328at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0030690; C:Noc1p-Noc2p complex; IBA:GO_Central.
DR   GO; GO:0030691; C:Noc2p-Noc3p complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR   GO; GO:0035067; P:negative regulation of histone acetylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR005343; Noc2.
DR   PANTHER; PTHR12687; PTHR12687; 1.
DR   Pfam; PF03715; Noc2; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Differentiation; Gonadal differentiation; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..719
FT                   /note="Nucleolar complex protein 2 homolog"
FT                   /id="PRO_0000315875"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..719
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..129
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..670
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   719 AA;  82485 MW;  2642CE3CE78EC1B8 CRC64;
     MKLLKKSSSL KKGVTKRAKL QKKPPSKDEA SSSDEELAKL DGEGSLDGNE SEEDDGTVQV
     EKGGMKKHKL DLEALKKSDP EFFKFLQQED ADLLNMEEDE DDDEEGEDNE DEEDEEEEEE
     SDEDDDEEDD DKTKIKKIRK PKVKSDSSGR LIVDSNVYSY LQQVLVLDDE TTTPINPSDV
     RMAIDVFVAC VARVGADIEA PKYVINEQSI FEAVVRMCFQ AMPDVLKRLL KARPDGEKVL
     FSKTMIKKYQ TYVRTYLHAM IVFLNEVQTT EVIIATLKAI TRLVDLYAHF SRMSKLLIKA
     IVKIWSRKTL ECRLPAFVCM NLLVKNYPQH FVPLYKTAYV AFVANSKVVT NETWPLLQFM
     HRTFAEITMI NPEQAYKYAF VYIRQTAVHL RNAMIAKGRK DLIFSIYNWQ MMQCMYMWVR
     VIAKAHSVNG AEQIGELVYP LIQVIVGIFK LCNAPTFLPL RLHCCQMLIQ LQASCTNYIP
     IMQLSCDCLE ELARELKSKP KPAKGAVKLP DIECTLKCST QYSDLPQWRK TISEHVFRTM
     MQSAHLLASQ AAFPDVALPI NHRIATILDT MKNADQAHLF RGFQTKLKEH SRFVLDVLAR
     KHVDLNDEMQ VRAVRFDLNN PDSPIKSFYR QWEKVWKMKE KSALENSKKD DKKKKKEEEA
     AKKRKATETL EDDDDEDAKP TIPKAKRKRI KIGAAAKRAD ATVPDQFADM SLANWSDED