NOC2L_CAEEL
ID NOC2L_CAEEL Reviewed; 715 AA.
AC O17580; A7UGI7; O17971; O18163; Q17785;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2013, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Nucleolar complex protein 2 homolog;
DE Short=Protein NOC2 homolog;
DE AltName: Full=Proximal proliferation in germline protein 2;
GN Name=pro-2; ORFNames=C07E3.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16876152; DOI=10.1016/j.ydbio.2006.06.011;
RA Voutev R., Killian D.J., Ahn J.H., Hubbard E.J.A.;
RT "Alterations in ribosome biogenesis cause specific defects in C. elegans
RT hermaphrodite gonadogenesis.";
RL Dev. Biol. 298:45-58(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for normal somatic gonad development and for
CC regulation of germline development and proliferation.
CC {ECO:0000269|PubMed:16876152}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Worms exhibit slow growth and sterility caused by
CC germline proliferation defective phenotype (Glp) or proximal germ cell
CC proliferation abnormal phenotype (Pro). {ECO:0000269|PubMed:16876152}.
CC -!- SIMILARITY: Belongs to the NOC2 family. {ECO:0000305}.
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DR EMBL; EU068465; ABU49430.1; -; mRNA.
DR EMBL; Z49908; CAA90103.2; -; Genomic_DNA.
DR EMBL; Z81573; CAA90103.2; JOINED; Genomic_DNA.
DR EMBL; Z99268; CAA90103.2; JOINED; Genomic_DNA.
DR PIR; T19060; T19060.
DR RefSeq; NP_496224.2; NM_063823.4.
DR AlphaFoldDB; O17580; -.
DR BioGRID; 39917; 4.
DR IntAct; O17580; 1.
DR STRING; 6239.C07E3.2; -.
DR iPTMnet; O17580; -.
DR EPD; O17580; -.
DR PaxDb; O17580; -.
DR PeptideAtlas; O17580; -.
DR EnsemblMetazoa; C07E3.2.1; C07E3.2.1; WBGene00007413.
DR GeneID; 174598; -.
DR KEGG; cel:CELE_C07E3.2; -.
DR UCSC; C07E3.2.1; c. elegans.
DR CTD; 174598; -.
DR WormBase; C07E3.2; CE47947; WBGene00007413; pro-2.
DR eggNOG; KOG2256; Eukaryota.
DR GeneTree; ENSGT00390000010057; -.
DR HOGENOM; CLU_399139_0_0_1; -.
DR InParanoid; O17580; -.
DR OMA; FPLRFHC; -.
DR OrthoDB; 1194328at2759; -.
DR PhylomeDB; O17580; -.
DR PRO; PR:O17580; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00007413; Expressed in larva and 4 other tissues.
DR GO; GO:0030690; C:Noc1p-Noc2p complex; IBA:GO_Central.
DR GO; GO:0030691; C:Noc2p-Noc3p complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR GO; GO:0035067; P:negative regulation of histone acetylation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005343; Noc2.
DR PANTHER; PTHR12687; PTHR12687; 1.
DR Pfam; PF03715; Noc2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Gonadal differentiation; Nucleus;
KW Reference proteome.
FT CHAIN 1..715
FT /note="Nucleolar complex protein 2 homolog"
FT /id="PRO_0000121051"
FT REGION 17..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..127
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 81954 MW; 52F296EEA4D9DF52 CRC64;
MKLLKKPAGL KKRKVISKRI KIEKKPSSED EGSSDEEVPK LDGEGSLDGS EDEDDGTVTV
EKGGVKKHKL DLEKLKQSDP EFFKFLQQED ADLLNMEDDG DDDEDDDEDD EDEEEEESDD
DEDDEEDDDK TKIKKIRKPK IKSDNSGRLI VDSNVYSYLQ QVLVLDDETS TPTNPSDVRM
AVDVFVACVA RVGADIEAPK YVINEQSIFE AVVRMCFQAM PDILKRLLKA KPEGDKVLFS
KTAIKKYQTY VRTYLHAMIV FLNEVQTTEV LIATIKAMTR LVDLYAHFSR MSKLLIKAVV
RIWSRKTLEC RLPAFVCMNL LVKNYPQHFV PLYKTAYVAF VANSKIVTNE TWPLLQFMHR
TFAELTILNP EQAYKYAFVY IRQTAVHLRN AMISKGRKDL IFSIYNWQMM QCMYMWVRVI
AKAHSVNGAE QIGELVYPLI QVIVGIFKLC NAPTFLPLRL HCCQLLIQLQ ASCTNYIPIL
QVSCDCLEEL ARELKSKPKP VKGAVKLPDI ECTLKCSSQF SDLPQWRKVI SEHVFRTMMQ
SAHLLASQAA FPDVVLPINH RISAILETMK NGDHAHLFRG FQTKLKEHSR FVLDVLARKS
VDINDEMQVR AVRFDLNNPD SPIKTFYRQW EKVWKMKERS AVENSKKDDK KKKKEEEAAA
AKKRKPNETV EDEDDVKPEV SKAKRKRIKI GAAAKKADAS VPDQFADMSM WSDED
