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NOC2_ARATH
ID   NOC2_ARATH              Reviewed;         764 AA.
AC   Q9ZPV5; F4IQG7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 2.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=Nucleolar complex-associated protein 2 {ECO:0000303|PubMed:30338215};
DE            Short=AtNOC2 {ECO:0000303|PubMed:30338215};
GN   Name=NOC2 {ECO:0000303|PubMed:30338215};
GN   OrderedLocusNames=At2g18220 {ECO:0000312|Araport:AT2G18220};
GN   ORFNames=T30D6.27 {ECO:0000312|EMBL:AAD15514.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH SWA2.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=19734265; DOI=10.1104/pp.109.142414;
RA   Li N., Yuan L., Liu N., Shi D., Li X., Tang Z., Liu J., Sundaresan V.,
RA   Yang W.-C.;
RT   "SLOW WALKER2, a NOC1/MAK21 homologue, is essential for coordinated cell
RT   cycle progression during female gametophyte development in Arabidopsis.";
RL   Plant Physiol. 151:1486-1497(2009).
RN   [4]
RP   INTERACTION WITH RBL; NOC3 AND SWA2, AND SUBCELLULAR LOCATION.
RX   PubMed=30338215; DOI=10.1002/2211-5463.12504;
RA   de Bossoreille S., Morel P., Trehin C., Negrutiu I.;
RT   "REBELOTE, a regulator of floral determinacy in Arabidopsis thaliana,
RT   interacts with both nucleolar and nucleoplasmic proteins.";
RL   FEBS Open Bio 8:1636-1648(2018).
CC   -!- FUNCTION: Together with SWA2, probably involved in pre-ribosome export
CC       from the nucleus to the cytoplasm. {ECO:0000303|PubMed:19734265}.
CC   -!- SUBUNIT: Component of nucleolar complexes (PubMed:30338215). Forms
CC       homodimers (PubMed:30338215). Interacts with RBL and NOC3 in both the
CC       nucleolus and nucleoplasm (PubMed:30338215). Binds to SWA2
CC       (PubMed:19734265, PubMed:30338215). {ECO:0000269|PubMed:19734265,
CC       ECO:0000269|PubMed:30338215}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC       Nucleus, nucleolus {ECO:0000269|PubMed:30338215}. Nucleus, nucleoplasm
CC       {ECO:0000269|PubMed:30338215}. Note=Also observed in nucleoplasmic
CC       bodies. {ECO:0000269|PubMed:30338215}.
CC   -!- SIMILARITY: Belongs to the NOC2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD15514.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC006439; AAD15514.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002685; AEC06741.1; -; Genomic_DNA.
DR   PIR; G84561; G84561.
DR   RefSeq; NP_179414.2; NM_127379.3.
DR   AlphaFoldDB; Q9ZPV5; -.
DR   BioGRID; 1694; 1.
DR   STRING; 3702.AT2G18220.1; -.
DR   iPTMnet; Q9ZPV5; -.
DR   PaxDb; Q9ZPV5; -.
DR   PRIDE; Q9ZPV5; -.
DR   ProteomicsDB; 250845; -.
DR   EnsemblPlants; AT2G18220.1; AT2G18220.1; AT2G18220.
DR   GeneID; 816337; -.
DR   Gramene; AT2G18220.1; AT2G18220.1; AT2G18220.
DR   KEGG; ath:AT2G18220; -.
DR   Araport; AT2G18220; -.
DR   TAIR; locus:2062205; AT2G18220.
DR   eggNOG; KOG2256; Eukaryota.
DR   HOGENOM; CLU_011272_2_0_1; -.
DR   InParanoid; Q9ZPV5; -.
DR   OMA; FPLRFHC; -.
DR   OrthoDB; 1194328at2759; -.
DR   PRO; PR:Q9ZPV5; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9ZPV5; baseline and differential.
DR   Genevisible; Q9ZPV5; AT.
DR   GO; GO:0030690; C:Noc1p-Noc2p complex; IBA:GO_Central.
DR   GO; GO:0030691; C:Noc2p-Noc3p complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   InterPro; IPR005343; Noc2.
DR   PANTHER; PTHR12687; PTHR12687; 1.
DR   Pfam; PF03715; Noc2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Nucleus; Reference proteome.
FT   CHAIN           1..764
FT                   /note="Nucleolar complex-associated protein 2"
FT                   /id="PRO_0000121052"
FT   REGION          23..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          627..646
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          651..726
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          3..69
FT                   /evidence="ECO:0000255"
FT   MOTIF           673..680
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   MOTIF           738..745
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        23..44
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..67
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..110
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..726
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   764 AA;  86961 MW;  AC4CA9B5F19A9E87 CRC64;
     MGAKDDKKRV KKLKSKKLEA EEELNNVQEI DAHDIVMEQK SDKKRGKKVK SKKAEAEEHE
     EELKRLQEKD PDFFQYMKEH DAELLKFDAT EIEDDADVEP DTDLEDTEKE GDDEATKMEI
     AKKVHVQKTI TASMVDAWSK SIEDEAKLGG VRSILRAYRT ACHYGDDTGD DQSTKFSVMS
     SEVFNKIMIY VLSEMDGILR KLLRFPEDTR GTKETILELT NTRPWKNYNH LVKSYLGNSL
     HVLNQMTDTE MITFTLRRLK HSSVFLAAFP SLLRKYIKVA LHFWGTGSGA LPVVSLLFLR
     DLCIRLGSDC VDDCFKGMYK AYVLNCQFVN ADKLKHISFL GNCFIELLGT DISAAYQHAF
     VFIRQLAMIL REALNTKTKE AFRKVYQWKF IHCLELWTGA VCAYSSQSEL RPVAYPLAQI
     ITGVARLVPT ARYTPLRLRC VRMLNRLAAA TGTFIPVSML LVDMLEMKEL NRPPTGGVGK
     GVDLRTLLKV SKPAVKTRAF QEACVYTVVE ELVEHLSQWS CSVAFFELSF IPTIRLRSFC
     KSTKAERFRK EMKQLISQIE ANSEFVNKKR ALIKFLPNDL AAESFLEDEK KAGKTPLLQY
     AEIIRQRAQQ RNESLVESDV IVGENSAVFG KNAPSSDDED DEDRMEKGAA AFNSSWLPGS
     DSKEKEPEEE KTKKKKRKRG GKSKTEKKQD EQGLGEDDVV EDFVLSSDEE EEDLFDIGGD
     KDEDDAVDEI ADPETKTSKK TKGTYKTWHK AYKKTKKKKA RVAS
 
 
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