NOC2_ARATH
ID NOC2_ARATH Reviewed; 764 AA.
AC Q9ZPV5; F4IQG7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Nucleolar complex-associated protein 2 {ECO:0000303|PubMed:30338215};
DE Short=AtNOC2 {ECO:0000303|PubMed:30338215};
GN Name=NOC2 {ECO:0000303|PubMed:30338215};
GN OrderedLocusNames=At2g18220 {ECO:0000312|Araport:AT2G18220};
GN ORFNames=T30D6.27 {ECO:0000312|EMBL:AAD15514.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, AND INTERACTION WITH SWA2.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=19734265; DOI=10.1104/pp.109.142414;
RA Li N., Yuan L., Liu N., Shi D., Li X., Tang Z., Liu J., Sundaresan V.,
RA Yang W.-C.;
RT "SLOW WALKER2, a NOC1/MAK21 homologue, is essential for coordinated cell
RT cycle progression during female gametophyte development in Arabidopsis.";
RL Plant Physiol. 151:1486-1497(2009).
RN [4]
RP INTERACTION WITH RBL; NOC3 AND SWA2, AND SUBCELLULAR LOCATION.
RX PubMed=30338215; DOI=10.1002/2211-5463.12504;
RA de Bossoreille S., Morel P., Trehin C., Negrutiu I.;
RT "REBELOTE, a regulator of floral determinacy in Arabidopsis thaliana,
RT interacts with both nucleolar and nucleoplasmic proteins.";
RL FEBS Open Bio 8:1636-1648(2018).
CC -!- FUNCTION: Together with SWA2, probably involved in pre-ribosome export
CC from the nucleus to the cytoplasm. {ECO:0000303|PubMed:19734265}.
CC -!- SUBUNIT: Component of nucleolar complexes (PubMed:30338215). Forms
CC homodimers (PubMed:30338215). Interacts with RBL and NOC3 in both the
CC nucleolus and nucleoplasm (PubMed:30338215). Binds to SWA2
CC (PubMed:19734265, PubMed:30338215). {ECO:0000269|PubMed:19734265,
CC ECO:0000269|PubMed:30338215}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC Nucleus, nucleolus {ECO:0000269|PubMed:30338215}. Nucleus, nucleoplasm
CC {ECO:0000269|PubMed:30338215}. Note=Also observed in nucleoplasmic
CC bodies. {ECO:0000269|PubMed:30338215}.
CC -!- SIMILARITY: Belongs to the NOC2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD15514.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006439; AAD15514.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06741.1; -; Genomic_DNA.
DR PIR; G84561; G84561.
DR RefSeq; NP_179414.2; NM_127379.3.
DR AlphaFoldDB; Q9ZPV5; -.
DR BioGRID; 1694; 1.
DR STRING; 3702.AT2G18220.1; -.
DR iPTMnet; Q9ZPV5; -.
DR PaxDb; Q9ZPV5; -.
DR PRIDE; Q9ZPV5; -.
DR ProteomicsDB; 250845; -.
DR EnsemblPlants; AT2G18220.1; AT2G18220.1; AT2G18220.
DR GeneID; 816337; -.
DR Gramene; AT2G18220.1; AT2G18220.1; AT2G18220.
DR KEGG; ath:AT2G18220; -.
DR Araport; AT2G18220; -.
DR TAIR; locus:2062205; AT2G18220.
DR eggNOG; KOG2256; Eukaryota.
DR HOGENOM; CLU_011272_2_0_1; -.
DR InParanoid; Q9ZPV5; -.
DR OMA; FPLRFHC; -.
DR OrthoDB; 1194328at2759; -.
DR PRO; PR:Q9ZPV5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZPV5; baseline and differential.
DR Genevisible; Q9ZPV5; AT.
DR GO; GO:0030690; C:Noc1p-Noc2p complex; IBA:GO_Central.
DR GO; GO:0030691; C:Noc2p-Noc3p complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR InterPro; IPR005343; Noc2.
DR PANTHER; PTHR12687; PTHR12687; 1.
DR Pfam; PF03715; Noc2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Reference proteome.
FT CHAIN 1..764
FT /note="Nucleolar complex-associated protein 2"
FT /id="PRO_0000121052"
FT REGION 23..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3..69
FT /evidence="ECO:0000255"
FT MOTIF 673..680
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 738..745
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 23..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..110
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..726
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 86961 MW; AC4CA9B5F19A9E87 CRC64;
MGAKDDKKRV KKLKSKKLEA EEELNNVQEI DAHDIVMEQK SDKKRGKKVK SKKAEAEEHE
EELKRLQEKD PDFFQYMKEH DAELLKFDAT EIEDDADVEP DTDLEDTEKE GDDEATKMEI
AKKVHVQKTI TASMVDAWSK SIEDEAKLGG VRSILRAYRT ACHYGDDTGD DQSTKFSVMS
SEVFNKIMIY VLSEMDGILR KLLRFPEDTR GTKETILELT NTRPWKNYNH LVKSYLGNSL
HVLNQMTDTE MITFTLRRLK HSSVFLAAFP SLLRKYIKVA LHFWGTGSGA LPVVSLLFLR
DLCIRLGSDC VDDCFKGMYK AYVLNCQFVN ADKLKHISFL GNCFIELLGT DISAAYQHAF
VFIRQLAMIL REALNTKTKE AFRKVYQWKF IHCLELWTGA VCAYSSQSEL RPVAYPLAQI
ITGVARLVPT ARYTPLRLRC VRMLNRLAAA TGTFIPVSML LVDMLEMKEL NRPPTGGVGK
GVDLRTLLKV SKPAVKTRAF QEACVYTVVE ELVEHLSQWS CSVAFFELSF IPTIRLRSFC
KSTKAERFRK EMKQLISQIE ANSEFVNKKR ALIKFLPNDL AAESFLEDEK KAGKTPLLQY
AEIIRQRAQQ RNESLVESDV IVGENSAVFG KNAPSSDDED DEDRMEKGAA AFNSSWLPGS
DSKEKEPEEE KTKKKKRKRG GKSKTEKKQD EQGLGEDDVV EDFVLSSDEE EEDLFDIGGD
KDEDDAVDEI ADPETKTSKK TKGTYKTWHK AYKKTKKKKA RVAS