NOC3L_DANRE
ID NOC3L_DANRE Reviewed; 800 AA.
AC Q6DRN3; Q6DC88;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Nucleolar complex protein 3 homolog;
DE Short=NOC3 protein homolog;
DE AltName: Full=NOC3-like protein;
DE AltName: Full=Nucleolar complex-associated protein 3-like protein;
GN Name=noc3l;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA Hopkins N.;
RT "Identification of 315 genes essential for early zebrafish development.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-483 (ISOFORM 2).
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6DRN3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6DRN3-2; Sequence=VSP_015759;
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH78188.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AY648726; AAT68044.1; -; mRNA.
DR EMBL; BC078188; AAH78188.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001002863.1; NM_001002863.1. [Q6DRN3-1]
DR AlphaFoldDB; Q6DRN3; -.
DR SMR; Q6DRN3; -.
DR STRING; 7955.ENSDARP00000004350; -.
DR PaxDb; Q6DRN3; -.
DR Ensembl; ENSDART00000028043; ENSDARP00000004350; ENSDARG00000002487. [Q6DRN3-1]
DR GeneID; 321289; -.
DR KEGG; dre:321289; -.
DR CTD; 64318; -.
DR ZFIN; ZDB-GENE-030131-9878; noc3l.
DR eggNOG; KOG2153; Eukaryota.
DR GeneTree; ENSGT00390000008540; -.
DR HOGENOM; CLU_012441_2_1_1; -.
DR InParanoid; Q6DRN3; -.
DR OMA; QKREFRT; -.
DR OrthoDB; 341721at2759; -.
DR PhylomeDB; Q6DRN3; -.
DR TreeFam; TF318817; -.
DR PRO; PR:Q6DRN3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 12.
DR Bgee; ENSDARG00000002487; Expressed in presomitic mesoderm and 42 other tissues.
DR ExpressionAtlas; Q6DRN3; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:ZFIN.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0007517; P:muscle organ development; IMP:ZFIN.
DR GO; GO:0019216; P:regulation of lipid metabolic process; IMP:ZFIN.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; PTHR14428; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Nucleus; Reference proteome.
FT CHAIN 1..800
FT /note="Nucleolar complex protein 3 homolog"
FT /id="PRO_0000173477"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 449..490
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 174
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_015759"
FT CONFLICT 124
FT /note="H -> R (in Ref. 2; AAH78188)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 800 AA; 92097 MW; 3A5FDD17A88B4BC8 CRC64;
MGPASKRNKK KRPSFRKLLK TSNLKLENKL KNRQFKQQSS AKKQRKEQRK LHKAISDVSH
QTLKPLERYK KRPEDEEEEE EFLESLPTDM MDEDDLEHIR AIAQKASFLT RDLSSCAPVH
AKKHKSEQAL ENYEKMPRKM QQEEEKELIH LLPIKDKSGL IPQSMEKPVL PQAEEEEEEP
NQEVYLQKEE EPESAPLLTP QEQFEQRAQK LMEKKLRIAA LSSAILADPH VNIKKLKELR
AMLMETDPCV AVTVRKLVMV SLMEVFKDIV PAYRIRPLTE EEKAAKVKKE TLQLREFEEG
LVSQYKFYLE ELEQTVKDWK QKKEKRSQAV SLQSYKGLAE VAVRCICELL VALPHFNFHN
NIIVMLVPLM NDSDKKVSEM CCEAVKKLLK QDKVGQASLA MVKVISGMVK SRNYRIKPVV
LNCLLCLRIK EVDMKKDTED TAPKKKFMSF KEKRKNLSRM QRKWKKAEEK LQKELLEAEA
TESKEKKIKL HTETLNVVFL IYFRILKKAQ KSVLLSSVLE GLAKFAHLIN LEFFDDLLAV
LYNLITSGDL TYRESLHCIL TSFHILSGQG DVLNIDPLKF YSHLYRTLLT LHAGGVNEDT
VIVLQCLDVM LSKRRKQVTL QRAQAFLKRL NTVALHLLPD SCVGILAANR MLMQTFPKCD
ILLDNETQGS GVYLPELDVP EYCNPQNTAL WELHLLKSHY HPVVRKFAAH LMKGAPSEGS
GALGVELSRR SPLQLFEDYS VKDMSFNPPV AGPPSKKKEY FTIGHAFLHS ELSRQIDAAL
QEEPEQMSLD FTSPHTQQEP
