NOC3L_DROME
ID NOC3L_DROME Reviewed; 822 AA.
AC Q9VI82;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Nucleolar complex protein 3 homolog;
DE Short=NOC3 protein homolog;
DE AltName: Full=NOC3-like protein;
DE AltName: Full=Nucleolar complex-associated protein 3-like protein;
GN ORFNames=CG1234;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187; THR-193 AND SER-198, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54043.1; -; Genomic_DNA.
DR EMBL; AY051854; AAK93278.1; -; mRNA.
DR RefSeq; NP_649710.1; NM_141453.5.
DR AlphaFoldDB; Q9VI82; -.
DR SMR; Q9VI82; -.
DR BioGRID; 66065; 17.
DR IntAct; Q9VI82; 8.
DR STRING; 7227.FBpp0081117; -.
DR iPTMnet; Q9VI82; -.
DR PaxDb; Q9VI82; -.
DR PRIDE; Q9VI82; -.
DR DNASU; 40870; -.
DR EnsemblMetazoa; FBtr0081599; FBpp0081117; FBgn0037489.
DR GeneID; 40870; -.
DR KEGG; dme:Dmel_CG1234; -.
DR UCSC; CG1234-RA; d. melanogaster.
DR FlyBase; FBgn0037489; CG1234.
DR VEuPathDB; VectorBase:FBgn0037489; -.
DR eggNOG; KOG2153; Eukaryota.
DR GeneTree; ENSGT00390000008540; -.
DR HOGENOM; CLU_012441_2_0_1; -.
DR InParanoid; Q9VI82; -.
DR OMA; QKREFRT; -.
DR OrthoDB; 341721at2759; -.
DR PhylomeDB; Q9VI82; -.
DR BioGRID-ORCS; 40870; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 40870; -.
DR PRO; PR:Q9VI82; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037489; Expressed in wing disc and 42 other tissues.
DR Genevisible; Q9VI82; DM.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; PTHR14428; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..822
FT /note="Nucleolar complex protein 3 homolog"
FT /id="PRO_0000173481"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 445..509
FT /evidence="ECO:0000255"
FT COMPBIAS 182..199
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 187
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 193
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 198
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 822 AA; 94492 MW; B6B724F9F83A4BC8 CRC64;
MGTKKVKISS VKRAAHLKSK KTPLSKQQQQ KQKQKRDQLK SKREQGQNIF SQKARKRDNL
AQRKKHNKLA SLGLDPLEED NEDGDDEMLE NVADMLDGDD LALLQANKRK RKAKTTGEND
PDQGQSIGLE RAYASDTKKE QDAQKIKLDL LPIKSRDGQI ITRTTEVDYI PKPKQKKKNE
EEEEDDSEED GDTEYEDSDD DVVNDVEAAT AAPVQKLIST TDLLIARQQE IERQKYRIGI
ICSGLLEKPE DKMRNFHALY ELMDEINPAS RQANLMAVRK LAIISVTEIF KDILPEYRVG
QVDTKMQTLR KATLDRVTFE NALLQQFKKF LQKLEQITAQ VNRRGGLRTP QTVKLATVAV
QCMCDLLVAH PYFNYVQNIA QLLVYMLNCN YAEMRTAVHQ CFRTVFSNDK RLEMTLFIVR
RINHLIKTKQ NNVHVECITC LMGLKIKNVN LDAEKENELK QKKLESHRQR LLSLSKKERK
RRKKLTEVNR ELEETRAEEN KQAKHQKLTE IIKMVFTIYF RVLKNDPTSR VLSAILEGLA
EFAHVINLDF FSDLIDVLNR ILEDQDELGY RERLHCVQTI FVILSGQGEV LNIDPIRFYQ
HFYRNMLAVQ AGKNHDDFAI ILRTLDEVLV KRRRNMSQQR LMAFMKRLLT GSLHLLHNGT
LATLGTIKQT FQLTSVLDNL LDTDTTIGSG RYDPELDDPE YCNAASTALY ELALLARHYH
PTVRRMAVHI AHGVPATGEG ALPTEIGKLT SHELFTQFDS TQMAFNPTIP LPKAGQPKLK
RGKHLYIRSD FKQEYGKLLQ QGKVSQTKDK QTLQIDFFSA LQ
