NOC3L_HUMAN
ID NOC3L_HUMAN Reviewed; 800 AA.
AC Q8WTT2; Q9H5M6; Q9H9D8;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Nucleolar complex protein 3 homolog;
DE Short=NOC3 protein homolog;
DE AltName: Full=Factor for adipocyte differentiation 24;
DE AltName: Full=NOC3-like protein;
DE AltName: Full=Nucleolar complex-associated protein 3-like protein;
GN Name=NOC3L; Synonyms=AD24, C10orf117, FAD24;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15564382; DOI=10.1242/jcs.01546;
RA Tominaga K., Johmura Y., Nishizuka M., Imagawa M.;
RT "Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte
RT differentiation.";
RL J. Cell Sci. 117:6217-6226(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-800, AND VARIANT ALA-472.
RC TISSUE=Hepatoma, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=12429849; DOI=10.1091/mbc.e02-05-0271;
RA Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C.,
RA Greco A., Hochstrasser D.F., Diaz J.-J.;
RT "Functional proteomic analysis of human nucleolus.";
RL Mol. Biol. Cell 13:4100-4109(2002).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-333, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be required for adipogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus speckle.
CC -!- TISSUE SPECIFICITY: Expressed in colon, heart, kidney, liver, lung,
CC placenta, skeletal muscle, small intestine, spleen and thymus.
CC {ECO:0000269|PubMed:15564382}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14291.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB15599.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB077992; BAB84194.1; -; mRNA.
DR EMBL; AL355341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049850; AAH49850.1; -; mRNA.
DR EMBL; AK022882; BAB14291.1; ALT_INIT; mRNA.
DR EMBL; AK026953; BAB15599.1; ALT_INIT; mRNA.
DR CCDS; CCDS7433.1; -.
DR RefSeq; NP_071896.8; NM_022451.10.
DR AlphaFoldDB; Q8WTT2; -.
DR SMR; Q8WTT2; -.
DR BioGRID; 122131; 206.
DR IntAct; Q8WTT2; 51.
DR MINT; Q8WTT2; -.
DR STRING; 9606.ENSP00000360412; -.
DR iPTMnet; Q8WTT2; -.
DR PhosphoSitePlus; Q8WTT2; -.
DR SwissPalm; Q8WTT2; -.
DR BioMuta; NOC3L; -.
DR DMDM; 74751495; -.
DR SWISS-2DPAGE; Q8WTT2; -.
DR EPD; Q8WTT2; -.
DR jPOST; Q8WTT2; -.
DR MassIVE; Q8WTT2; -.
DR MaxQB; Q8WTT2; -.
DR PaxDb; Q8WTT2; -.
DR PeptideAtlas; Q8WTT2; -.
DR PRIDE; Q8WTT2; -.
DR ProteomicsDB; 74598; -.
DR Antibodypedia; 30528; 201 antibodies from 29 providers.
DR DNASU; 64318; -.
DR Ensembl; ENST00000371361.3; ENSP00000360412.3; ENSG00000173145.11.
DR GeneID; 64318; -.
DR KEGG; hsa:64318; -.
DR MANE-Select; ENST00000371361.3; ENSP00000360412.3; NM_022451.11; NP_071896.8.
DR UCSC; uc001kjq.2; human.
DR CTD; 64318; -.
DR DisGeNET; 64318; -.
DR GeneCards; NOC3L; -.
DR HGNC; HGNC:24034; NOC3L.
DR HPA; ENSG00000173145; Low tissue specificity.
DR MalaCards; NOC3L; -.
DR MIM; 610769; gene.
DR neXtProt; NX_Q8WTT2; -.
DR OpenTargets; ENSG00000173145; -.
DR PharmGKB; PA134887727; -.
DR VEuPathDB; HostDB:ENSG00000173145; -.
DR eggNOG; KOG2153; Eukaryota.
DR GeneTree; ENSGT00390000008540; -.
DR HOGENOM; CLU_012441_2_1_1; -.
DR InParanoid; Q8WTT2; -.
DR OMA; QKREFRT; -.
DR OrthoDB; 341721at2759; -.
DR PhylomeDB; Q8WTT2; -.
DR TreeFam; TF318817; -.
DR PathwayCommons; Q8WTT2; -.
DR SignaLink; Q8WTT2; -.
DR SIGNOR; Q8WTT2; -.
DR BioGRID-ORCS; 64318; 489 hits in 1088 CRISPR screens.
DR ChiTaRS; NOC3L; human.
DR GenomeRNAi; 64318; -.
DR Pharos; Q8WTT2; Tbio.
DR PRO; PR:Q8WTT2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8WTT2; protein.
DR Bgee; ENSG00000173145; Expressed in secondary oocyte and 195 other tissues.
DR Genevisible; Q8WTT2; HS.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; PTHR14428; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..800
FT /note="Nucleolar complex protein 3 homolog"
FT /id="PRO_0000173474"
FT REGION 27..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 451..490
FT /evidence="ECO:0000255"
FT COMPBIAS 38..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 787
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT CROSSLNK 333
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 194
FT /note="P -> L (in dbSNP:rs12572897)"
FT /id="VAR_023549"
FT VARIANT 444
FT /note="P -> R (in dbSNP:rs11187895)"
FT /id="VAR_048621"
FT VARIANT 472
FT /note="E -> A (in dbSNP:rs3758526)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_023550"
FT VARIANT 504
FT /note="R -> I (in dbSNP:rs11187892)"
FT /id="VAR_048622"
FT VARIANT 655
FT /note="T -> S (in dbSNP:rs12259382)"
FT /id="VAR_048623"
FT VARIANT 695
FT /note="A -> T (in dbSNP:rs17517578)"
FT /id="VAR_048624"
SQ SEQUENCE 800 AA; 92548 MW; 4471F5C6246F53C9 CRC64;
MKARRNKKQI PSFRKLIKTS KVKLENKLKN KQFKQQSTLK KYRKEQRKLR QAVKDAVSKK
PIPLENPKEK RPGKRIEREE EEEEEALPLD MMDEDDLQLM KDLGQRVSFL TRDLSSSEPV
HAKKRKHERI IDKYEKIPRT LQTAPEKELI HLLPIKDKSG IIPQTREKPV TDSNKDEEDQ
EEERELEEEI IEDPIQELTI EEHLIERKKK LQEKKMHIAA LASAILSDPE NNIKKLKELR
SMLMEQDPDV AVTVRKLVIV SLMELFKDIT PSYKIRPLTE AEKSTKTRKE TQKLREFEEG
LVSQYKFYLE NLEQMVKDWK QRKLKKSNVV SLKAYKGLAE VAVKSLCELL VALPHFNFHN
NIIVLIVPLM NDMSKLISEM CCEAVKKLFK QDKLGQASLG VIKVISGFVK GRNYEVRPEM
LKTFLCLRIK EVEVKKDTED INKPKKFMTF KEKRKSLSRM QRKWKKAEEK LERELREAEA
SESTEKKLKL HTETLNIVFV TYFRILKKAQ RSPLLPAVLE GLAKFAHLIN VEFFDDLLVV
LHTLIESGDL SYQESLHCVQ TAFHILSGQG DVLNIDPLKF YTHLYKTLFK LHAGATNEGV
EIVLQCLDVM LTKRRKQVSQ QRALAFIKRL CTLALHVLPN SSIGILATTR ILMHTFPKTD
LLLDSESQGS GVFLPELDEP EYCNAQNTAL WELHALRRHY HPIVQRFAAH LIAGAPSEGS
GALKPELSRR SATELFEAYS MAEMTFNPPV ESSNPKIKGK FLQGDSFLNE DLNQLIKRYS
SEVATESPLD FTKYLKTSLH
