NOC3L_MOUSE
ID NOC3L_MOUSE Reviewed; 807 AA.
AC Q8VI84; E9QQ46; Q9JKM3;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Nucleolar complex protein 3 homolog;
DE Short=NOC3 protein homolog;
DE AltName: Full=Factor for adipocyte differentiation 24;
DE AltName: Full=NOC3-like protein;
DE AltName: Full=Nucleolar complex-associated protein 3-like protein;
GN Name=Noc3l; Synonyms=Ad24, Fad24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=15564382; DOI=10.1242/jcs.01546;
RA Tominaga K., Johmura Y., Nishizuka M., Imagawa M.;
RT "Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte
RT differentiation.";
RL J. Cell Sci. 117:6217-6226(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 468-807.
RX PubMed=11146508;
RX DOI=10.1002/1097-0177(2000)9999:9999<::aid-dvdy1089>3.0.co;2-x;
RA Tidhar A., Reichenstein M., Cohen D., Faerman A., Copeland N.G.,
RA Gilbert D.J., Jenkins N.A., Shani M.;
RT "A novel transgenic marker for migrating limb muscle precursors and for
RT vascular smooth muscle cells.";
RL Dev. Dyn. 220:60-73(2001).
CC -!- FUNCTION: May be required for adipogenesis.
CC {ECO:0000269|PubMed:15564382}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15564382}.
CC Nucleus speckle {ECO:0000269|PubMed:15564382}.
CC -!- INDUCTION: Induced between 1 and 12 hours following adipogenic
CC stimulus. {ECO:0000269|PubMed:15564382}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family. {ECO:0000305}.
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DR EMBL; AB077991; BAB84193.1; -; mRNA.
DR EMBL; AC101775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC111023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC158131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031132; AAH31132.1; -; mRNA.
DR EMBL; AF233884; AAF40207.1; -; mRNA.
DR CCDS; CCDS37974.1; -.
DR RefSeq; NP_067290.2; NM_021315.2.
DR AlphaFoldDB; Q8VI84; -.
DR SMR; Q8VI84; -.
DR BioGRID; 208315; 31.
DR IntAct; Q8VI84; 2.
DR MINT; Q8VI84; -.
DR STRING; 10090.ENSMUSP00000025963; -.
DR iPTMnet; Q8VI84; -.
DR PhosphoSitePlus; Q8VI84; -.
DR EPD; Q8VI84; -.
DR MaxQB; Q8VI84; -.
DR PaxDb; Q8VI84; -.
DR PeptideAtlas; Q8VI84; -.
DR PRIDE; Q8VI84; -.
DR ProteomicsDB; 293867; -.
DR Antibodypedia; 30528; 201 antibodies from 29 providers.
DR DNASU; 57753; -.
DR Ensembl; ENSMUST00000025963; ENSMUSP00000025963; ENSMUSG00000024999.
DR GeneID; 57753; -.
DR KEGG; mmu:57753; -.
DR UCSC; uc008hjr.2; mouse.
DR CTD; 64318; -.
DR MGI; MGI:1932610; Noc3l.
DR VEuPathDB; HostDB:ENSMUSG00000024999; -.
DR eggNOG; KOG2153; Eukaryota.
DR GeneTree; ENSGT00390000008540; -.
DR HOGENOM; CLU_012441_2_1_1; -.
DR InParanoid; Q8VI84; -.
DR OMA; QKREFRT; -.
DR OrthoDB; 341721at2759; -.
DR PhylomeDB; Q8VI84; -.
DR TreeFam; TF318817; -.
DR BioGRID-ORCS; 57753; 24 hits in 75 CRISPR screens.
DR ChiTaRS; Noc3l; mouse.
DR PRO; PR:Q8VI84; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8VI84; protein.
DR Bgee; ENSMUSG00000024999; Expressed in humerus cartilage element and 242 other tissues.
DR Genevisible; Q8VI84; MM.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; IDA:MGI.
DR GO; GO:0005730; C:nucleolus; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0045444; P:fat cell differentiation; IMP:MGI.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; PTHR14428; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation.
FT CHAIN 1..807
FT /note="Nucleolar complex protein 3 homolog"
FT /id="PRO_0000173475"
FT REGION 27..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 449..489
FT /evidence="ECO:0000255"
FT COMPBIAS 38..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..191
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 332
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8WTT2"
FT CONFLICT 173
FT /note="V -> L (in Ref. 1; BAB84193 and 3; AAH31132)"
FT /evidence="ECO:0000305"
FT CONFLICT 744
FT /note="T -> S (in Ref. 4; AAF40207)"
FT /evidence="ECO:0000305"
FT CONFLICT 751
FT /note="S -> C (in Ref. 4; AAF40207)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 807 AA; 93211 MW; 497734D35EF7707C CRC64;
MKARRNKKQV PSFRKLIKTS KVKLENKLKN KQFKQQSTIK KYRKEQRKLR QAVKDAVSKK
PIPLEDPKSK RPVKRMEREE DEEEEALPLD MMDEDDLQLM KDLGQKASFL TRDLSSSEPV
HIKKRKHESV IEKYEKVPRT LQTAPEKELI HLLPIKDKSG IIPQAREKPV TDVQQEEEAE
EELEDEEEVI EDPRKELTIE EHVIERKKKL QDKKIQIAAL ASAILSDPES HIKKLKELRS
MLMEQDPDVA VTVRKLVIIS LMELFKDITP SYKIRPLTEA EKSTKIRKET QKLREFEEGL
VSQYKFYLEN LEQIVKDWKQ RKLKKSNVVS LKAYKGLAEV AVKSLCELLV ALPHFNFHNN
IIVLIVPLMN DGSKPVSEMC CEAVKKLFKQ DKLGQASLGV IKVISGFVKG RNYEVRPEML
KTFLCLRIKE VEVKKDTEDI NKPKRFMTFK EKRKTLSRMQ RKWKKAEEKL ERELREAEAS
ESTEKKLKLH TETLNIVFVT YFRILKKAQK SPLLPAVLEG LAKFAHLINV EFFDDLLVVL
HTLIESGELS YQESLHCVQT AFHILSGQGD VLNIDPMKFY THLYKTLFTL HAGATNDGIE
IVLHCLDVML SKRRKQVSHQ RALAFIKRLC TLALQVLPNS SIGLLATTRI LMHTFPRTDL
LLDNESQGSG VFLPELEEPE YCNAQNTALW ELHTLRRHYH PIVRRFAAHL LAGAPSEGSE
ALKPELSRRS AVELFETYSM AAMTFNPPVE SSHSKRKDKF LPGDSFLNED LNQLIKRYCN
EAAPETPLDF AKCLESSSRQ YRVNGLS
