NOC3_ARATH
ID NOC3_ARATH Reviewed; 830 AA.
AC F4IDJ0; A0MEH1; O64537; Q1KS85; Q6NME0;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Nucleolar complex-associated protein 3 {ECO:0000303|PubMed:17556508, ECO:0000303|PubMed:30338215};
DE Short=AtNOC3 {ECO:0000303|PubMed:17556508};
GN Name=NOC3 {ECO:0000303|PubMed:17556508, ECO:0000303|PubMed:30338215};
GN OrderedLocusNames=At1g79150 {ECO:0000312|Araport:AT1G79150};
GN ORFNames=YUP8H12R.24 {ECO:0000312|EMBL:AAC17047.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 520-830 (ISOFORM 1/2).
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP REVIEW ON THE CORE DNA REPLICATION MACHINERY, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=17556508; DOI=10.1104/pp.107.101105;
RA Shultz R.W., Tatineni V.M., Hanley-Bowdoin L., Thompson W.F.;
RT "Genome-wide analysis of the core DNA replication machinery in the higher
RT plants Arabidopsis and rice.";
RL Plant Physiol. 144:1697-1714(2007).
RN [7]
RP INTERACTION WITH RBL AND NOC2, AND SUBCELLULAR LOCATION.
RX PubMed=30338215; DOI=10.1002/2211-5463.12504;
RA de Bossoreille S., Morel P., Trehin C., Negrutiu I.;
RT "REBELOTE, a regulator of floral determinacy in Arabidopsis thaliana,
RT interacts with both nucleolar and nucleoplasmic proteins.";
RL FEBS Open Bio 8:1636-1648(2018).
CC -!- FUNCTION: May be required for synthesis of 60S ribosomal subunits and
CC the transport of pre-ribosomes from the nucleoplasm to the cytoplasm
CC (By similarity). Also required for initiation of DNA replication
CC (PubMed:17556508). {ECO:0000250|UniProtKB:Q07896,
CC ECO:0000303|PubMed:17556508}.
CC -!- SUBUNIT: Component of nucleolar complexes (PubMed:30338215). Interacts
CC with RBL and NOC2 in both the nucleolus and nucleoplasm
CC (PubMed:30338215). {ECO:0000269|PubMed:30338215}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC Nucleus, nucleolus {ECO:0000269|PubMed:30338215}. Nucleus, nucleoplasm
CC {ECO:0000269|PubMed:30338215}. Note=Also observed in nucleoplasmic
CC bodies. {ECO:0000269|PubMed:30338215}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4IDJ0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4IDJ0-2; Sequence=VSP_061347, VSP_061348;
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC17047.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ABK28474.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC002986; AAC17047.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE36209.1; -; Genomic_DNA.
DR EMBL; DQ459177; ABE97175.1; -; mRNA.
DR EMBL; DQ652941; ABK28474.1; ALT_SEQ; mRNA.
DR EMBL; AK226761; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BT011720; AAS49083.1; -; mRNA.
DR PIR; T01041; T01041.
DR RefSeq; NP_178036.2; NM_106566.4.
DR AlphaFoldDB; F4IDJ0; -.
DR STRING; 3702.AT1G79150.1; -.
DR PaxDb; F4IDJ0; -.
DR PRIDE; F4IDJ0; -.
DR ProteomicsDB; 204324; -.
DR EnsemblPlants; AT1G79150.1; AT1G79150.1; AT1G79150. [F4IDJ0-1]
DR GeneID; 844256; -.
DR Gramene; AT1G79150.1; AT1G79150.1; AT1G79150. [F4IDJ0-1]
DR KEGG; ath:AT1G79150; -.
DR Araport; AT1G79150; -.
DR TAIR; locus:2207370; AT1G79150.
DR eggNOG; KOG2153; Eukaryota.
DR HOGENOM; CLU_012441_4_0_1; -.
DR InParanoid; F4IDJ0; -.
DR OMA; QKREFRT; -.
DR OrthoDB; 341721at2759; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4IDJ0; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; PTHR14428; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; DNA replication; Nucleus;
KW Reference proteome; Ribosome biogenesis.
FT CHAIN 1..830
FT /note="Nucleolar complex-associated protein 3"
FT /id="PRO_0000454496"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 61..81
FT /evidence="ECO:0000255"
FT COILED 111..156
FT /evidence="ECO:0000255"
FT COILED 400..429
FT /evidence="ECO:0000255"
FT MOTIF 138..145
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 408..415
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 806..813
FT /note="Nuclear localization signal 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 112..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..830
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 484..495
FT /note="TEEIPTSNPGAF -> YLYIHFCNHFSK (in isoform 2)"
FT /id="VSP_061347"
FT VAR_SEQ 496..830
FT /note="Missing (in isoform 2)"
FT /id="VSP_061348"
SQ SEQUENCE 830 AA; 94890 MW; 8E0C7263E26EAFD6 CRC64;
MGKNRRKQKV IPPPLLPPDV AEEDIEFSDE DLKYVKENTD YAQFVSQIDT AAINKQCGGR
VMTVEDKYEE ERSKRKTLQE EKGNGEILVD PVDVLPVKTL DGKLHYRTES KKSKLAEAET
DEAEKDVLED EHVLNKSQRR EKAKKSKREA KKHEKDLPDE ILQEEEETPQ AAVLAEVKEE
LSAEESFENK KNKIAELGML LLSDPEANIK TLKDMLDICK DQNTKIVKLA LLSLLAVFKD
IIPGYRIRLP TEKELEMKIS KEVKKTRFYE STLLKAYKSY LQKLIIFEKQ SVYNQIANRC
LCTLLEAVPH FNYRDNLLIA VVRNISSPDE VVRRLCCSTI RYLFSNEGKH GGELTVQAVR
LIADHVKAHN CQLHPNAIEV FMSIRFDEDI GKPNKEDEHN KKYKKNNKRK TQEEQNQVQE
NERKKSKKDM MSKIRDEVSA DHRGVTYEPD AKERRKMQTE TLSAVFETYF RILRNTMYTI
GERTEEIPTS NPGAFGSHPL LAPCLDGLAK FTQQLDLDYM GDLMNYLKKL ASSSSSVSNN
TKQKNSKLLT VSERLRCCLV AFKVMRSNLN ALNVDLQDFF VQLYNLILEY RPGRDSGVIL
AESLKIMLCD DRHQDMQKAA AFVKRLATFA LCFGCAESMS ALVTLKTLLQ KNVKCRNLLE
NDAGGGSVSG SIAKYQPYAT DPNLSGALAT VLWELSLLSK HYHPAISTMA TTVSNMNTSQ
SQTFLSAVTP QQAFADFSLV KESFEPKNES RKLNNKRKRE SLPEEAKNVP EIDMVKLSKK
LKENFTILRD IKEDERVRME LLQSEEKKPL KKQNNVVKKK LKNPKSKKQI
