NOC3_SCHPO
ID NOC3_SCHPO Reviewed; 747 AA.
AC O94288; Q9US68;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Nucleolar complex-associated protein 3;
GN Name=noc3; ORFNames=SPBC887.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 38-104, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: May be required for synthesis of 60S ribosomal subunits and
CC the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10759889}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA21888.1; -; Genomic_DNA.
DR EMBL; AB028010; BAA87314.1; -; Genomic_DNA.
DR PIR; T40728; T40728.
DR RefSeq; NP_596477.1; NM_001022397.2.
DR AlphaFoldDB; O94288; -.
DR SMR; O94288; -.
DR BioGRID; 277744; 1.
DR STRING; 4896.SPBC887.03c.1; -.
DR iPTMnet; O94288; -.
DR MaxQB; O94288; -.
DR PaxDb; O94288; -.
DR EnsemblFungi; SPBC887.03c.1; SPBC887.03c.1:pep; SPBC887.03c.
DR GeneID; 2541230; -.
DR KEGG; spo:SPBC887.03c; -.
DR PomBase; SPBC887.03c; noc3.
DR VEuPathDB; FungiDB:SPBC887.03c; -.
DR eggNOG; KOG2153; Eukaryota.
DR HOGENOM; CLU_012441_3_0_1; -.
DR InParanoid; O94288; -.
DR OMA; QKREFRT; -.
DR PhylomeDB; O94288; -.
DR PRO; PR:O94288; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030691; C:Noc2p-Noc3p complex; ISO:PomBase.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; PTHR14428; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Phosphoprotein; Reference proteome;
KW Ribosome biogenesis.
FT CHAIN 1..747
FT /note="Nucleolar complex-associated protein 3"
FT /id="PRO_0000173482"
FT REGION 1..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 214..234
FT /evidence="ECO:0000255"
FT COMPBIAS 26..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 120
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 747 AA; 85100 MW; 4F211F5F7F8FF748 CRC64;
MAARKNQKSP KPKVASSKLK NIKKSSKRNN SQSSTEPRKN ATSLDSKKTT KKGVALPEIA
ERELTQEDIE FFNENPSSLK YLSSINPEDL GKKVEKGPRP DIYDLKKSQQ FELDTSRLSS
DEESVLDYSK DSEDEQDYEL RPRVSSSWNN ESYNRLPIKT KDGLLQNVVA DVNNGEEFLS
ESESEASLEI DSDIKDEKQK SLEEQKIAPE IPVKQQIKND KEALGIQAQQ LLEEPVENLH
LIRNIFEKFD SPYITIKKLS LLTLLAVFRD IIPGYKIRPL SEEEQGTKLS KEVAQRWEYE
QTLLKHYAKF LQTLETILKS FSSTLDETQL SLYQVAVRCC TKLIEQASHF NLSEKLFALA
VRQISHKTKR PGFDGIINSL KNIFEEDNLG KTSLKCVTIL SRMFKQRNYD VLPDVYDLFL
SVNILNDMKI KDEAWQDDTT NFKKRKKDLP YLTKKARKNY KETKKITQEM KEADAVITAQ
DKEKYQSEIL KIIFITYFKT LQLKGKLIGN ALEGVARLSH LLNIEFLGDL LQVLRELVMD
DTVFLPKDKS GVQATREALL TVSTAFEIAS AQGVGKLNLD LDLGLFVQRL YKIIFPFSLN
PDADLNLKIK RLKDPDAPSK PFVVNATTEM EMLLKCFQVF FFKSKNISSS RLSSFSKRLA
IASMQLPEHS ASADLALLKK LLSRYSKLSR LLTSEEQIGD GIYNPFIEDP DLSNSSTAVL
YEPFLLKNHY SPAVSQSAKE LLKSTSL
