NOC4L_HUMAN
ID NOC4L_HUMAN Reviewed; 516 AA.
AC Q9BVI4; Q8N2S5; Q96I14;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Nucleolar complex protein 4 homolog;
DE Short=NOC4 protein homolog;
DE AltName: Full=NOC4-like protein;
DE AltName: Full=Nucleolar complex-associated protein 4-like protein;
GN Name=NOC4L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Eye, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=12429849; DOI=10.1091/mbc.e02-05-0271;
RA Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C.,
RA Greco A., Hochstrasser D.F., Diaz J.-J.;
RT "Functional proteomic analysis of human nucleolus.";
RL Mol. Biol. Cell 13:4100-4109(2002).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q9BVI4; O14503: BHLHE40; NbExp=3; IntAct=EBI-395927, EBI-711810;
CC Q9BVI4; Q96EY1-2: DNAJA3; NbExp=3; IntAct=EBI-395927, EBI-3952284;
CC Q9BVI4; Q68J44: DUSP29; NbExp=3; IntAct=EBI-395927, EBI-1054321;
CC Q9BVI4; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-395927, EBI-6255981;
CC Q9BVI4; Q13422: IKZF1; NbExp=3; IntAct=EBI-395927, EBI-745305;
CC Q9BVI4; P19012: KRT15; NbExp=4; IntAct=EBI-395927, EBI-739566;
CC Q9BVI4; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-395927, EBI-12805508;
CC Q9BVI4; Q9C0E8-2: LNPK; NbExp=3; IntAct=EBI-395927, EBI-11024283;
CC Q9BVI4; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-395927, EBI-12813389;
CC Q9BVI4; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-395927, EBI-79165;
CC Q9BVI4; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-395927, EBI-947187;
CC Q9BVI4; Q8N6Y0: USHBP1; NbExp=2; IntAct=EBI-395927, EBI-739895;
CC Q9BVI4; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-395927, EBI-12287587;
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:12429849};
CC Multi-pass membrane protein {ECO:0000269|PubMed:12429849}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:12429849}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family. {ECO:0000305}.
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DR EMBL; BC001191; AAH01191.1; -; mRNA.
DR EMBL; BC007893; AAH07893.2; -; mRNA.
DR EMBL; BC071958; AAH71958.1; -; mRNA.
DR CCDS; CCDS9277.1; -.
DR RefSeq; NP_076983.1; NM_024078.2.
DR AlphaFoldDB; Q9BVI4; -.
DR SMR; Q9BVI4; -.
DR BioGRID; 122508; 167.
DR DIP; DIP-32938N; -.
DR IntAct; Q9BVI4; 64.
DR MINT; Q9BVI4; -.
DR STRING; 9606.ENSP00000328854; -.
DR iPTMnet; Q9BVI4; -.
DR PhosphoSitePlus; Q9BVI4; -.
DR SwissPalm; Q9BVI4; -.
DR BioMuta; NOC4L; -.
DR DMDM; 73621312; -.
DR SWISS-2DPAGE; Q9BVI4; -.
DR EPD; Q9BVI4; -.
DR jPOST; Q9BVI4; -.
DR MassIVE; Q9BVI4; -.
DR MaxQB; Q9BVI4; -.
DR PaxDb; Q9BVI4; -.
DR PeptideAtlas; Q9BVI4; -.
DR PRIDE; Q9BVI4; -.
DR ProteomicsDB; 79209; -.
DR Antibodypedia; 19475; 91 antibodies from 27 providers.
DR DNASU; 79050; -.
DR Ensembl; ENST00000330579.6; ENSP00000328854.1; ENSG00000184967.7.
DR Ensembl; ENST00000672504.1; ENSP00000500901.1; ENSG00000288146.1.
DR GeneID; 79050; -.
DR KEGG; hsa:79050; -.
DR MANE-Select; ENST00000330579.6; ENSP00000328854.1; NM_024078.3; NP_076983.1.
DR UCSC; uc001ujz.1; human.
DR CTD; 79050; -.
DR GeneCards; NOC4L; -.
DR HGNC; HGNC:28461; NOC4L.
DR HPA; ENSG00000184967; Low tissue specificity.
DR MIM; 612819; gene.
DR neXtProt; NX_Q9BVI4; -.
DR OpenTargets; ENSG00000184967; -.
DR PharmGKB; PA142671262; -.
DR VEuPathDB; HostDB:ENSG00000184967; -.
DR eggNOG; KOG2154; Eukaryota.
DR GeneTree; ENSGT00390000016776; -.
DR HOGENOM; CLU_015945_3_0_1; -.
DR InParanoid; Q9BVI4; -.
DR OMA; DVRYYTF; -.
DR OrthoDB; 891751at2759; -.
DR PhylomeDB; Q9BVI4; -.
DR TreeFam; TF105812; -.
DR PathwayCommons; Q9BVI4; -.
DR Reactome; R-HSA-6790901; rRNA modification in the nucleus and cytosol.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR SignaLink; Q9BVI4; -.
DR BioGRID-ORCS; 79050; 637 hits in 1086 CRISPR screens.
DR ChiTaRS; NOC4L; human.
DR GenomeRNAi; 79050; -.
DR Pharos; Q9BVI4; Tdark.
DR PRO; PR:Q9BVI4; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9BVI4; protein.
DR Bgee; ENSG00000184967; Expressed in right testis and 96 other tissues.
DR ExpressionAtlas; Q9BVI4; baseline and differential.
DR Genevisible; Q9BVI4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030692; C:Noc4p-Nop14p complex; IBA:GO_Central.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR027193; Noc4.
DR PANTHER; PTHR12455; PTHR12455; 1.
DR Pfam; PF03914; CBF; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..516
FT /note="Nucleolar complex protein 4 homolog"
FT /id="PRO_0000173484"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 516 AA; 58468 MW; 656D835CB4207DF8 CRC64;
MEREPGAAGV RRALGRRLEA VLASRSEANA VFDILAVLQS EDQEEIQEAV RTCSRLFGAL
LERGELFVGQ LPSEEMVMTG SQGATRKYKV WMRHRYHSCC NRLGELLGHP SFQVKELALS
ALLKFVQLEG AHPLEKSKWE GNYLFPRELF KLVVGGLLSP EEDQSLLLSQ FREYLDYDDT
RYHTMQAAVD AVARVTGQHP EVPPAFWNNA FTLLSAVSLP RREPTVSSFY VKRAELWDTW
KVAHLKEHRR VFQAMWLSFL KHKLPLSLYK KVLLIVHDAI LPQLAQPTLM IDFLTRACDL
GGALSLLALN GLFILIHKHN LEYPDFYRKL YGLLDPSVFH VKYRARFFHL ADLFLSSSHL
PAYLVAAFAK RLARLALTAP PEALLMVLPF ICNLLRRHPA CRVLVHRPHG PELDADPYDP
GEEDPAQSRA LESSLWELQA LQRHYHPEVS KAASVINQAL SMPEVSIAPL LELTAYEIFE
RDLKKKGPEP VPLEFIPAQG LLGRPGELCA QHFTLS
